bis-[2-(2-chloro-acetylamino)-ethyl]-disulfide | 70642-10-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: bis-[2-(2-chloro-acetylamino)-ethyl]-disulfide
• 英文别名: Bis-[2-(2-chlor-acetylamino)-aethyl]-disulfid；β,β'-Bis-chloracetamino-diaethyldisulfid；Bis-(β-chloracetamino-aethyl)-disulfid；N,N'-(disulfanediyldiethane-2,1-diyl)bis(2-chloroacetamide)；N,N'-(disulphanediyldiethane-2,1-diyl)bis(2-chloroacetamide)；2-chloro-N-[2-[2-[(2-chloroacetyl)amino]ethyldisulfanyl]ethyl]acetamide
• CAS: 70642-10-3
• 化学式: C₈H₁₄Cl₂N₂O₂S₂
• 分子量: 305.249
• InChiKey: MNOUPDJZWCCVLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  bis-[2-(2-chloro-acetylamino)-ethyl]-disulfide 在 sodium azide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 以1.64 g的产率得到
  参考文献：
  名称：

  碳酸酐酶II中的立体和区域选择性叠氮化物/炔烃环加成反应，通过束缚，通过晶体学和质谱法进行监测

  摘要：

  制备了碳酸酐酶II突变体His64Cys，并将其用于拴系的炔烃/叠氮化物环加成反应。叠氮化物组分可以通过二硫键连接到酶的表面，而炔烃组分则通过磺酰胺锚与酶的原始催化中心的锌离子可逆地配位。通过结晶学表征反应物在结合位点和形成的三唑产物的初始取向。反应进程可通过HPLC-MS分析进行监控。

  DOI：

  10.1002/chem.201002437
• 作为产物：
  描述：

  胱胺 、 氯乙酰氯 在 乙醚 、 水 、 potassium carbonate 作用下， 生成 bis-[2-(2-chloro-acetylamino)-ethyl]-disulfide
  参考文献：
  名称：

  v.Braun; Bahn; Muench, Chemische Berichte, 1929, vol. 62, p. 2769

  摘要：

  DOI：

文献信息

• [EN] INDOLINIUM-DERIVED THIOL/DISULFIDE DYE, DYE COMPOSITION COMPRISNG THIS DYE, PROCESS FOR LIGHTENING KERATIN MATERIALS USING THIS DYE<br/>[FR] COLORANT THIOL/DISULFURE DÉRIVÉ D'INDOLIUM, COMPOSITION COLORANTE COMPRENANT LEDIT COLORANT, PROCÉDÉ D'ÉCLAIRCISSEMENT DE MATÉRIAUX À BASE DE KÉRATINE AU MOYEN DE CE COLORANT
  申请人：OREAL

  公开号：WO2009037348A1

  公开（公告）日：2009-03-26

  The invention relates to the dyeing of keratin materials using indolinium-derived thiol and disulfide fluorescent dyes. The invention relates to a dye composition comprising an indolinium-derived-chromophore thiol or disulfide dye and to a dyeing process with a lightening effect on keratin fibers such as the hair, using said composition. It similarly relates to novel indolinium-derived-chromophore thiol dyes and to the uses thereof in lightening keratin materials. This composition makes it possible to obtain a coloring with a lightening effect which is particularly resistant and visible on dark keratin fibers.

  该发明涉及使用吲哚啉衍生硫醇和二硫化物荧光染料对角蛋白材料进行染色。该发明涉及一种染料组合物，包括一种吲哚啉衍生色团硫醇或二硫化物染料，以及使用该组合物对角蛋白纤维（如头发）进行具有减淡效果的染色过程。它还涉及新型吲哚啉衍生色团硫醇染料及其在减淡角蛋白材料中的用途。该组合物能够实现一种具有减淡效果的染色，特别是在深色角蛋白纤维上表现出耐久性和可见性。
• HEMICYANIN STYRYL THIOL/DISULFIDE DYE, COMPOSITION COMPRISING HEMICYANIN STYRYL THIOL/DISULFIDE DYE, AND METHOD FOR LIGHTENING KERATIN MATERIALS USING HEMICYANIN STYRYL THIOL/DISULFIDE DYE
  申请人：GREAVES Andrew

  公开号：US20090211038A1

  公开（公告）日：2009-08-27

  The present disclosure relates to a novel dye composition for the dyeing and/or lightening of keratin materials, such dye comprising a hemicyanin styryl chromophore thiol or disulfide dye of formula (I) or (II): the organic or mineral acid salts thereof, optical isomers and geometric isomers thereof, and the solvates thereof such as hydrates. The present disclosure further relates to a dyeing process with a lightening effect on keratin materials, in particular keratin fibers, including human keratin fibers such as the hair, using said composition. This composition makes it possible to obtain a coloring with a lightening effect which is particularly resistant and visible on dark keratin fibers.

  本公开涉及一种用于染色和/或轻化角蛋白材料的新型染料组合物，所述染料包括式(I)或(II)的半氰靛基苯乙烯色团硫醇或二硫化物染料：其有机或矿物酸盐、其光学异构体和几何异构体，以及其溶剂化合物，如水合物。本公开还涉及一种对角蛋白材料，特别是角蛋白纤维，包括人类角蛋白纤维如头发，在使用所述组合物时具有轻化效果的染色过程。该组合物能够获得一种特别耐用且在深色角蛋白纤维上可见的具有轻化效果的染色。
• STYRYL THIOL/DISULFIDE COMPOUND WITH A HYDROXY(CYCLO)ALKYLAMINO UNIT, PROCESS FOR LIGHTENING KERATIN MATERIALS USING SAME
  申请人：DAUBRESSE Nicolas

  公开号：US20090172897A1

  公开（公告）日：2009-07-09

  The disclosure relates to the dyeing of keratin materials using styryl hydroxy(cyclo)alkylamino thiol/disulfide fluorescent dyes. Disclosed herein is a dye composition comprising a styryl hydroxy(cyclo)alkylamino thiol/disulfide fluorescent dye and a dyeing process with, for example, a lightening effect on keratin materials such as hair, using said composition. Disclosed herein are novel thiol/disulfide fluorescent dyes and the uses thereof in lightening keratin materials. This composition makes it possible to obtain a lightening effect which can be resistant and visible on dark keratin fibers.

  本公开涉及使用苯乙烯基羟基(环)烷基氨基硫醇/二硫化物荧光染料染色角蛋白质材料。本公开揭示了一种染料组合物，包括苯乙烯基羟基(环)烷基氨基硫醇/二硫化物荧光染料和染色工艺，例如，使用该组合物对角蛋白质材料（如头发）进行漂白效果的染色。本公开揭示了新型硫醇/二硫化物荧光染料及其在漂白角蛋白质材料中的用途。该组合物可以获得对深色角蛋白纤维具有耐久性和可见性的漂白效果。
• METHOD OF DYEING AND LIGHTENING KERATIN MATERIALS IN THE PRESENCE OF A REDUCING AGENT COMPRISING A FLUORESCENT DISULPHIDE DYE
  申请人：Daubresse Nicolas

  公开号：US20090313769A1

  公开（公告）日：2009-12-24

  The invention relates to a dyeing composition comprising a fluorescent disulphide dye and to a method of dyeing keratin materials, with a lightening effect, that employs said composition. It likewise relates to new fluorescent disulphide dyes and to their uses in the lightening of keratin materials. This composition allows a particularly persistent lightening effect to be obtained.

  该发明涉及一种染料组合物，包括荧光二硫化物染料，以及使用该组合物进行具有漂白效果的角蛋白材料染色的方法。它还涉及新的荧光二硫化物染料及其在角蛋白材料漂白中的用途。该组合物可使得特别持久的漂白效果得以获得。
• Hemicyanin styryl thiol/disulfide dye, composition comprising hemicyanin styryl thoil/disulfide dye, and method for lightening keratin materials using hemicyanin styryl thiol/disulfide dye
  申请人：L'Oreal S.A.

  公开号：US07727287B2

  公开（公告）日：2010-06-01

  The present disclosure relates to a novel dye composition for the dyeing and/or lightening of keratin materials, such dye comprising a hemicyanin styryl chromophore thiol or disulfide dye of formula (I) or (II): the organic or mineral acid salts thereof, optical isomers and geometric isomers thereof, and the solvates thereof such as hydrates. The present disclosure further relates to a dyeing process with a lightening effect on keratin materials, in particular keratin fibers, including human keratin fibers such as the hair, using said composition. This composition makes it possible to obtain a coloring with a lightening effect which is particularly resistant and visible on dark keratin fibers.

  本公开涉及一种新型染料组合物，用于染色和/或漂白角蛋白质材料，其中该染料包括式（I）或（II）的半青素基苯乙烯基色团硫醇或二硫醇染料：其有机或矿物酸盐、其光学异构体和几何异构体，以及其溶剂化物，例如水合物。本公开还涉及一种具有漂白效果的角蛋白质材料，特别是角蛋白纤维的染色工艺，包括人体角蛋白纤维，例如头发，使用该组合物。该组合物使得在深色角蛋白质纤维上获得特别耐用和明显的漂白效果。