2-[2-(4-甲基苯氧基)乙氧基]乙醇 | 104-39-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 2-[2-(4-甲基苯氧基)乙氧基]乙醇
• 中文别名: 2-[2-(甲苯氧基)乙氧基]乙醇
• 英文名称: 2-(2-p-tolyloxyethoxy)ethanol
• 英文别名: Ethanol, 2-[2-(4-methylphenoxy)ethoxy]-；2-[2-(4-methylphenoxy)ethoxy]ethanol
• CAS: 104-39-2
• 化学式: C₁₁H₁₆O₃
• 分子量: 196.246
• InChiKey: DXYXGWDDTLAPGM-UHFFFAOYSA-N

物化性质

• 沸点：
  327.4±27.0 °C(Predicted)
• 密度：
  1.071±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-[2-(4-甲基苯氧基)乙氧基]乙醇 、 氯乙酸 在 KU-2-8 cation-exchange resin H(+)-form 作用下， 以 甲苯 为溶剂， 以58.3%的产率得到2-(2-p-tolyloxyethoxy)ethyl chloroacetate
  参考文献：
  名称：

  Molecular and crystal structure of 2-(2-p-tolyloxyethoxy)ethylchloroacetate

  摘要：

  合成了 2-(2-对聚氧乙氧基)乙基氯乙酸盐，并对其进行了单晶 X 射线衍射分析。

  DOI：

  10.1007/s10947-010-0058-3
• 作为产物：
  描述：

  对溴甲苯 、 苯胺 、 二乙二醇 在 copper(II) acetate monohydrate 、 potassium carbonate 作用下， 反应 8.0h， 以74%的产率得到4-甲基-N-苯基苯胺
  参考文献：
  名称：

  Quebrachitol 或二甘醇促进的铜 (II)-催化芳基卤化物和 N-亲核试剂的 C-N 偶联

  摘要：

  在本文中，我们报告了天然配体 quebrachitol (QCT) 作为 Cu(II) 催化剂的促进剂，它对各种胺和相关芳基卤化物的 N-芳基化非常有效。通过使用二甘醇（DEG）作为配体和溶剂，以高收率获得了一系列二芳胺衍生物。C-N偶联反应在温和的条件下进行并表现出良好的官能团耐受性。

  DOI：

  10.1055/s-0039-1690707

文献信息

• PROCESS FOR PRODUCING SYNTHETIC RESIN FOAM, BLOWING AGENT, AND PREMIX
  申请人：Daikin Industries, Ltd.

  公开号：EP1498439A1

  公开（公告）日：2005-01-19

  The present invention relates to a process for producing a synthetic resin foam which comprises reacting at least one polyol with at least one polyisocyanate compound in the presence of an organic blowing agent, wherein the organic blowing agent is a blowing agent for synthetic resin foams which is characterized by being a mixture comprising 1,1,1,3,3-pentafluorobutane (HFC-365mfc) and at least one halogen-containing compound and optionally containing at least one member selected from the group consisting of glycol compounds and amide compounds. Also provided are: a premix comprising the blowing agent and a polyol mixture; and a process for producing a synthetic resin foam from these.

  本发明涉及一种生产合成树脂泡沫塑料的工艺，该工艺包括在有机发泡剂存在的情况下，使至少一种多元醇与至少一种多异氰酸酯化合物反应，其中有机发泡剂是一种用于合成树脂泡沫塑料的发泡剂，其特点是它是一种混合物，包括1,1,1,3,3-五氟丁烷(HFC-365mfc)和至少一种含卤化合物，并可选择地含有至少一种选自乙二醇化合物和酰胺化合物组成的组的成员。此外，还提供了：包含发泡剂和多元醇混合物的预混料；以及用其生产合成树脂泡沫塑料的工艺。
• COMPOSITION FOR EXTERNAL USE
  申请人：ROHTO PHARMACEUTICAL CO., LTD.

  公开号：EP1849481A1

  公开（公告）日：2007-10-31

  An object of the present invention is to provide a composition for external use in which the percutaneous absorbability of vitamin A, vitamin A derivative(s), vitamin C, specific vitamin C derivative(s), xanthine derivative(s), ubiquinone(s) and/or hyaluronic acid is improved. The composition for external use is prepared by blending (i) a phospholipid and (ii) a mono- or oligo-glycol ether, together with (iv) at least one bioactive component selected from the group consisting of hyaluronic acid, hyaluronic acid derivatives, vitamin A, vitamin A derivatives, vitamin C, specific vitamin C derivatives, xanthine derivatives, ubiquinones, and salts thereof.

  本发明的目的是提供一种外用组合物，其中维生素 A、维生素 A 衍生物、维生素 C、特定维生素 C 衍生物、黄嘌呤衍生物、泛素酮和/或透明质酸的经皮吸收性得到改善。 外用组合物的制备方法是将(i)磷脂和(ii)单-或寡-乙二醇醚与(iv)至少一种生物活性成分混合在一起，这些生物活性成分选自透明质酸、透明质酸衍生物、维生素 A、维生素 A 衍生物、维生素 C、特定维生素 C 衍生物、黄嘌呤衍生物、泛醌及其盐类组成的组。
• Dental hydraulic temporary sealing material composition
  申请人：GC Corporation

  公开号：EP2371345A1

  公开（公告）日：2011-10-05

  To provide a dental hydraulic temporary sealing material composition setting faster than conventional composition, excellent adhesiveness with cavity, and extremely good operativity of filling in an oral cavity, the dental hydraulic temporary sealing material composition includes calcium sulfate, a vinyl acetate resin, an inorganic filler, alcohols having a boiling point of 110°C or more, and a nonionic surfactant, whereby water on a cavity can adhere, without being repelled, to a paste surface due to hydrophilic effect between an organic solvent having proper hydrophilicity and the nonionic surfactant, the water can permeate and diffuse rapidly and stably through the inside of the paste by the hydrophilic effect so as to set faster than conventional composition, and since the hydrophilic effect is effective for adhesiveness with cavity, filling property in an oral cavity becomes extremely good.

  为了提供一种牙科液压临时密封材料组合物，该组合物比传统组合物固化速度更快，与龋洞的粘附性极佳，在口腔中填充的操作性极好，该牙科液压临时密封材料组合物包括硫酸钙、醋酸乙烯树脂、无机填料、沸点为 110°C 或更高的醇和非离子表面活性剂、由于具有适当亲水性的有机溶剂和非离子表面活性剂之间的亲水效应，空腔上的水可以不被排斥地附着在膏体表面，水可以通过亲水效应快速稳定地渗透和扩散到膏体内部，从而比传统组合物凝固得更快，而且由于亲水效应可以有效地与空腔粘合，口腔的填充性能变得非常好。
• Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides
  申请人：Arvinas, Inc.

  公开号：US10723717B2

  公开（公告）日：2020-07-28

  The present disclosure relates to bifunctional compounds, which find utility as modulators of Rapidly Accelerated Fibrosarcoma (RAF, such as c-RAF, A-RAF and/or B-RAF; the target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein RAF, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein, or the constitutive activation of the target protein, are treated or prevented with compounds and compositions of the present disclosure.

  本公开涉及双功能化合物，它们可用作快速加速纤维肉瘤（RAF，如c-RAF、A-RAF和/或B-RAF；靶蛋白）的调节剂。特别是，本公开内容涉及双功能化合物，其一端含有与相应 E3 泛素连接酶结合的 Von Hippel-Lindau、cereblon、抑制细胞凋亡蛋白或小鼠双敏同源物 2 配体，另一端含有与靶蛋白 RAF 结合的分子，从而将靶蛋白置于泛素连接酶附近，以实现对靶蛋白的降解（和抑制）。本公开物具有与降解/抑制靶蛋白相关的广泛药理活性。本公开的化合物和组合物可以治疗或预防由于靶蛋白的聚集或积聚或靶蛋白的组成性激活而导致的疾病或失调。
• Process for producing synthetic resin foam, blowing agent and premix
  申请人：Shibanuma Takashi

  公开号：US20050131091A1

  公开（公告）日：2005-06-16

  The present invention relates to a process for producing a synthetic resin foam which comprises reacting at least one polyol with at least one polyisocyanate compound in the presence of an organic blowing agent, wherein the organic blowing agent is a blowing agent for synthetic resin foams which is characterized by being a mixture comprising 1,1,1,3,3-pentafluorobutane (HFC-365mfc) and at least one halogen-containing compound and optionally containing at least one member selected from the group consisting of glycol compounds and amide compounds. Also provided are: a premix comprising the blowing agent and a polyol mixture; and a process for producing a synthetic resin foam from these.

  本发明涉及一种生产合成树脂泡沫塑料的工艺，该工艺包括在有机发泡剂存在的情况下，使至少一种多元醇与至少一种多异氰酸酯化合物反应，其中有机发泡剂是一种用于合成树脂泡沫塑料的发泡剂，其特点是它是一种混合物，包括1,1,1,3,3-五氟丁烷(HFC-365mfc)和至少一种含卤化合物，并可选择地含有至少一种选自乙二醇化合物和酰胺化合物组成的组的成员。此外，还提供了：包含发泡剂和多元醇混合物的预混料；以及用其生产合成树脂泡沫塑料的工艺。