2-[2-[2-[2-[2-[2-[2-(4-辛基苯氧基)乙氧基]乙氧基]乙氧基]乙氧基]乙氧基]乙氧基]乙醇 | 32742-88-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-[2-[2-[2-[2-[2-[2-(4-辛基苯氧基)乙氧基]乙氧基]乙氧基]乙氧基]乙氧基]乙氧基]乙醇
• 英文名称: OP-7
• 英文别名: 20-(4-octylphenoxy)-3,6,9,12,15,18-hexaoxaicosan-1-ol；2-[2-[2-[2-[2-[2-[2-(4-octylphenoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
• CAS: 32742-88-4
• 化学式: C₂₈H₅₀O₈
• 分子量: 514.7
• InChiKey: IZCAZGDGLZWLNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  36
• 可旋转键数：
  28
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  84.8
• 氢给体数：
  1
• 氢受体数：
  8

安全信息

• 海关编码：
  2909499000

反应信息

• 作为反应物：
  描述：

  2-[2-[2-[2-[2-[2-[2-(4-辛基苯氧基)乙氧基]乙氧基]乙氧基]乙氧基]乙氧基]乙氧基]乙醇 、 丙烯酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以94.75%的产率得到OP-7-AC
  参考文献：
  名称：

  Temperature-Responsive Properties of Poly(acrylic acid-co-acrylamide) Hydrophobic Association Hydrogels with High Mechanical Strength

  摘要：

  A novel type of hydrophobic association hydrogels (HA-gels) was prepared through micellar copolymerization of acrylic acid (AA), acrylamide (AAm) as basic monomers and a small amount of octylphenol polyoxyethylene ether acrylate with seven ethoxyl units (OP7-AC) as hydrophobic association monomer The HA gels exhibited desirable mechanical property and stably reversible phase transition between opaque and transparency The influences of adding urea and varying AA AAm molar ratio on the phase transition behavior were discussed, which indicated that the phase transition was introduced by forming or dissociating of hydrogen bonding between amide and carboxyl groups The introduction of hydrophobic units (OP7-AC) to poly(acrylic acid-co acrylamide) (P(AA-AAm)) copolymer would result in the adulterating and cross linking effects on the transition temperature The former sharply reduced the transition temperature while the later gradually raised it The transition temperature became linearly dropping with the increasing sodium dodecyl sulfate (SDS) content in the HA gels Therefore, the phase transition temperature can be finely adjusted by means of changing AA AAm ratio, concentration, OP7 AC and/or SDS dosages in the synthesis of HA gels

  DOI：

  10.1021/ma1022555

文献信息

• Delivery vehicles for bioactive agents and uses thereof
  申请人：Southern Research Institute

  公开号：US20020169138A1

  公开（公告）日：2002-11-14

  Compositions for transporting a bioactive agent across a biological membrane include the bioactive agent, an oil, an oil-immiscible compound and a noncationic surface active agent. The compositions may deliver the bioactive agent through a chemical microporulation mechanism, which allows transfer of the agent across both cellular, intracellular organelle, and nuclear membranes. Compositions for nucleic acid delivery include nucleic acid, oil, oil-immiscible compound, noncationic surface active agent and essentially no cationic lipid, or include nucleic acid, oil, oil-immiscible compound and two noncationic surface active agents. The nucleic acid may be hydrophobically-modified, and be in combination with an oil, an oil-immiscible compound and at least one surface active agent. The compositions may be used for gene delivery to a cell, as well as delivery of other therapeutic agents.

  用于跨生物膜传输生物活性剂的组合物包括生物活性剂、油、油不溶性化合物和非阳离子表面活性剂。这些组合物可通过化学微孔机制输送生物活性剂，从而实现生物活性剂在细胞膜、细胞内细胞器和核膜上的转移。用于递送核酸的组合物包括核酸、油、油不溶性化合物、非阳离子表面活性剂和基本不含阳离子的脂质，或包括核酸、油、油不溶性化合物和两种非阳离子表面活性剂。核酸可进行疏水改性，并与油、油不混溶化合物和至少一种表面活性剂结合使用。这些组合物可用于向细胞输送基因，也可用于输送其他治疗剂。
• RADIAL FLOW ASSAY
  申请人：INTRACEL CORPORATION

  公开号：EP0738391A1

  公开（公告）日：1996-10-23
• MODIFIED LYSINE OR ARGININE CONTAINING PROTEINS AND PEPTIDES
  申请人：THE NEW YORK BLOOD CENTER

  公开号：EP0820295A1

  公开（公告）日：1998-01-28
• EP0820295A4
  申请人：——

  公开号：EP0820295A4

  公开（公告）日：1998-06-10
• NANOSTRUCTURED AQUEOUS FUELS
  申请人：MASSACHUSETTS INSTITUTE OF TECHNOLOGY

  公开号：EP0934374A2

  公开（公告）日：1999-08-11