5-methoxy-4-methyl-pentanoic acid | 89795-04-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5-methoxy-4-methyl-pentanoic acid
• 英文别名: (+/-)-5-Methoxy-4-methyl-pentansaeure；5-Methoxy-4-methylpentanoic acid
• CAS: 89795-04-0
• 化学式: C₇H₁₄O₃
• 分子量: 146.186
• InChiKey: ACVUZEYHFBDHJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-methoxy-4-methyl-pentanoic acid 在 癸二酸单甲酯 、 sodium methylate 作用下， 以 甲醇 为溶剂， 生成 (+/-)-1,8-Dimethoxy-2,7-dimethyl-octan
  参考文献：
  名称：

  711.脂肪族羟基酸。第二部分。一些末端取代的异酸

  摘要：

  DOI：

  10.1039/jr9640003678
• 作为产物：
  描述：

  1-methoxy-2-methyl-3-propanol 、 丙二酸二乙酯 生成 5-methoxy-4-methyl-pentanoic acid
  参考文献：
  名称：

  943.脂肪族羟基酸。第一部分。皂苷元降解产物

  摘要：

  DOI：

  10.1039/jr9620004836

文献信息

• 3-Carbamoyl-2-Pyridone Derivative
  申请人：Ishizuka Natsuki

  公开号：US20080103139A1

  公开（公告）日：2008-05-01

  The present invention provides compounds having an agonistic activity to the cannabinoid receptor, which is represented by the formula (I): wherein R 1 is optionally substituted C1-C8 alkyl and the like; R 2 is C1-C6 alkyl; R 3 is C1-C6 alkyl and the like; or R 2 and R 3 taken together with may form an optionally substituted 5 to 10 membered non-aromatic carbon ring; R 4 is hydrogen and the like; G is a group selected from the groups shown by the formula an the like: wherein R 5 is hydrogen and the like; X 1 is a single bond and the like; X 2 is optionally substituted C1-C8 alkylene that may be replaced by one or two groups of —O—, or —N(R 6 )—, wherein R 6 is hydrogen and the like, and the like; X 3 is a single bond and the like; a pharmaceutically acceptable salt or a solvate thereof, and pharmaceutical compositions, atopic dermatitis treating agents, and anti-pruritus agents, especially anti-pruritus agents for oral used and for external application, which each contains the said compound as an active ingredient.

  本发明提供了具有激动大麻素受体的作用的化合物，其由式（I）表示：其中，R1是可选取的取代的C1-C8烷基等；R2是C1-C6烷基；R3是C1-C6烷基等；或R2和R3共同形成可选取代的5至10个成员的非芳香碳环；R4是氢等；G是由式等所示的基团中选取的基团：其中，R5是氢等；X1是单键等；X2是可选取代的C1-C8烷基，可以被一或两个-O-或-N（R6）-的基团替代，其中R6是氢等；X3是单键等；其药学上可接受的盐或其溶剂，以及制药组合物、治疗特应性皮炎的制剂和抗瘙痒剂，特别是口服和外用的抗瘙痒剂，每种制剂均以所述化合物为活性成分。
• 3-CARBAMOYL-2-PYRIDONE DERIVATIVE
  申请人：SHIONOGI & CO., LTD.

  公开号：EP1806342B1

  公开（公告）日：2013-04-17
• PROCESS FOR THE CARBONYLATION OF CONJUGATED DIENES USING A PALLADIUM CATALYST SYSTEM
  申请人：DSM IP Assets B.V.

  公开号：EP1656336A1

  公开（公告）日：2006-05-17
• Process for the carbonylation of conjugated dienes using a palladium catalyst system
  申请人：Sielcken Erik Otto

  公开号：US20070155984A1

  公开（公告）日：2007-07-05

  A process is provided, in particular a continuous process for the carbonylation of butadiene by reacting the butadiene with carbon monoxide and a hydroxyl group-containing compound in the presence of a palladium catalyst system in a reaction zone to form a reaction mixture, said catalyst system comprising (a) a source of palladium cations, (b) a mono-, bi- or multidentate phosphine ligand, containing at least one phosphorus atom which is directly bound to two or three aliphatic carbon atoms, as process ligand to produce a palladium-phosphine ligand complex catalyst, and (c) a source of anions, said process ligand (b) containing the moiety shown in formula (I), wherein A 1 and A 2 each represent an aliphatic carbon atom which can be connected to one or more aliphatic or aromatic carbon atoms or both A 1 and A 2 are part of an at least 5-membered ring including the phosphorus atom, and X represents an aliphatic or aromatic carbon atom which can be connected to one or more aliphatic or aromatic carbon atoms or X is part of an organic bridging group connecting another identically or differently substituted phosphorus atom, and said source of anions (c) containing a carboxylic acid and, optionally, halide ions, wherein said process ligand is fed continuously or periodically to the process as ligand make-up at a temperature 50° C. or lower.
• US7820849B2
  申请人：——

  公开号：US7820849B2

  公开（公告）日：2010-10-26