5-indolylurea | 13114-66-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-indolylurea
• 英文别名: N-1H-indol-5-ylUrea；1H-indol-5-ylurea
• CAS: 13114-66-4
• 化学式: C₉H₉N₃O
• mdl: MFCD20547480
• 分子量: 175.19
• InChiKey: YHZGWTSWBLYORR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  70.9
• 氢给体数：
  3
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N,N-bis(2-chloroethyl)-o-cyanoaniline 、 3-(4-aminobutyl)-5-indolylurea 、 5-indolylurea 以 水 、 丙酮 为溶剂， 生成 3-[4-(4-o-Cyanophenylpiperazino)butyl]-5-indolylurea, hydrochloride
  参考文献：
  名称：

  Indole derivatives

  摘要：

  公式I中的吲哚衍生物##STR1##其中Ind，Q和Ar的定义如本文所述，以及它们的盐，在中枢神经系统上具有活性。

  公开号：

  US05418237A1

文献信息

• [EN] SUBSTITUTED INDOLE COMPOUNDS AND THEIR USE AS 5-HT6 RECEPTOR MODULATORS<br/>[FR] COMPOSES D'INDOLE SUBSTITUES ET UTILISATION DE CEUX-CI COMME MODULATEURS DES RECEPTEURS 5-HT6
  申请人：ESTEVE LABOR DR

  公开号：WO2006024535A1

  公开（公告）日：2006-03-09

  The present invention relates to substituted indole compound of general formula I, a process for their preparation, medicaments comprising substituted indole compounds as well as the use of substituted indole compounds for the preparation of medicaments, which are suitable e.g. for the prophylaxis and/or treatment of disorders or diseases that are at least partially mediated via 5-HT6 receptors.

  本发明涉及通式I的取代吲哚化合物，其制备方法，包含取代吲哚化合物的药物，以及利用取代吲哚化合物制备药物，该药物适用于预防和/或治疗至少部分通过5-HT6受体介导的紊乱或疾病。
• [EN] ACTIVE SUBSTANCE COMBINATION COMPRISING A COMPOUND WITH NPY RECEPTOR AFFINITY AND A COMPOUND WITH 5-HT6 RECEPTOR AFFINITY<br/>[FR] COMBINAISON DE SUBSTANCES ACTIVES COMPORTANT UN COMPOSE A AFFINITE DE RECEPTEUR NPY ET UN COMPOSE A AFFINITE DE RECEPTEUR 5-HT6
  申请人：ESTEVE LABOR DR

  公开号：WO2005014000A1

  公开（公告）日：2005-02-17

  The present invention relates to an active substance combination comprising at least one compound with neuropeptide Y-receptor affinity and at least one compound with 5-HT6 receptor affinity, a medicament comprising said active substance combination, and the use of said active substance combination for the manufacture of a medicament.

  本发明涉及一种活性物质组合，包括至少一种具有神经肽Y受体亲和力的化合物和至少一种具有5-HT6受体亲和力的化合物，以及包含所述活性物质组合的药物和利用该活性物质组合制造药物的用途。
• [EN] INDOL-5-YL SULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE 5-HT-6 AS MODULATORS<br/>[FR] DERIVES D'INDOL-5-YL SULFONAMIDE, FABRICATION ET UTILISATION EN TANT QUE MODULATEURS DE 5-HT-6
  申请人：ESTEVE LABOR DR

  公开号：WO2005013977A1

  公开（公告）日：2005-02-17

  The present invention refers to new sulfonamide derivatives, of general formula (1a, 1b, 1c) optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their racemate, or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or their salts, preferably the corresponding, physiologically acceptable salts, or corresponding solvates; to the processes for their preparation, to their application as medicaments in human and/or veterinary therapeutics, and to the pharmaceutical compositions containing them.

  本发明涉及新的磺胺类衍生物，一般式为（1a、1b、1c），可选地为它们的立体异构体之一，最好是对映体或二对映体，它们的消旋体，或者以至少两种立体异构体之一的混合物形式，最好是对映体或二对映体，在任何混合比例下，或者它们的盐，最好是相应的生理上可接受的盐，或相应的溶剂合物；以及它们的制备方法，它们作为人类和/或兽医治疗药物的应用，以及含有它们的药物组合物。
• SUBSTITUTED INDOLE COMPOUNDS AND THEIR USE AS 5-HT6 RECEPTOR MODULATORS
  申请人：Merce Vidal Ramon

  公开号：US20070213326A1

  公开（公告）日：2007-09-13

  The present invention relates to substituted indole compound of general formula I, a process for their preparation, medicaments comprising substituted indole compounds as well as the use of substituted indole compounds for the preparation of medicaments, which are suitable e.g. for the prophylaxis and/or treatment of disorders or diseases that are at least partially mediated via 5-HT 6 receptors.

  本发明涉及通式I的取代吲哚化合物、其制备方法、含有取代吲哚化合物的药物以及利用取代吲哚化合物制备药物的用途，其中所述药物适用于预防和/或治疗至少部分通过5-HT6受体介导的紊乱或疾病。
• Active substance combination comprising a compound with npy receptor affinity and a compound with 5-ht6 receptor affinity
  申请人：Torrens Jover Antoni

  公开号：US20070009597A1

  公开（公告）日：2007-01-11

  The present invention relates to an active substance combination comprising at least one compound with neuropeptide Y-receptor affinity, preferably neuropeptide Y5-receptor affinity, and at least one compound with 5-HT 6 receptor affinity, a medicament comprising said active substance combination, and the use of said active substance combination for the manufacture of a medicament.

  本发明涉及一种活性物质组合，包括至少一种具有神经肽Y受体亲和力的化合物，优选为神经肽Y5受体亲和力，以及至少一种具有5-HT6受体亲和力的化合物，一种包含该活性物质组合的药物，以及使用该活性物质组合制造药物。