1,1'-biimidazole | 125934-36-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1,1'-biimidazole
• 英文别名: bi-imidazole；1-imidazol-1-ylimidazole
• CAS: 125934-36-3
• 化学式: C₆H₆N₄
• 分子量: 134.14
• InChiKey: QXVYTPLRWBDUNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  35.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• HETEROCYCLIC DERIVED METALLOPROTEASE INHIBITORS
  申请人：Zhang Yue-Mei

  公开号：US20080103129A1

  公开（公告）日：2008-05-01

  This invention provides novel heterocyclic derived matrix metalloprotease inhibitors of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing matrix metalloproteases. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.

  这项发明提供了一种新颖的杂环衍生物基质金属蛋白酶抑制剂的化学式，以及包含同样化合物的药物组合物，用于治疗通过拮抗基质金属蛋白酶而改善的疾病。该发明还提供了使用即时药物组合物的治疗和预防方法。
• Halo resistent, photoimagable coverlay compositions, having, advantageous application and removal properties, and methods relating thereto
  申请人：——

  公开号：US20040058276A1

  公开（公告）日：2004-03-25

  A flexible, aqueous processible, photoimagable coverlay compositions, having advantageous adhesion and release properties and resistance to (unwanted) haloing. The coverlay compositions of the present invention comprise an acrylic, low Tg, graft copolymer binder component, having an alkali resistant backbone-segment and a pendant arm segment comprising hydrophilic moieties. Optionally, the coverlay further comprises a thiophene-type adhesion promoter to further improve adhesion properties.

  一种灵活、水溶性、光敏覆盖层组合物，具有优异的粘附和释放性能以及抗（不需要的）晕影性能。本发明的覆盖层组合物包括具有耐碱骨架段和含亲水性基团的悬臂臂段的丙烯酸低Tg嫁接共聚物粘合剂组分。可选地，覆盖层进一步包括一种噻吩型粘附促进剂，以进一步改善粘附性能。
• UREA AND AMIDE DERIVATIVES OF AMINOALKYLPIPERAZINES AND USE THEREOF
  申请人：SOUTHERN RESEARCH INSTITUTE

  公开号：US20150232435A1

  公开（公告）日：2015-08-20

  Provided are compounds represented by the formula: with Y, Ri, and R2 being defined in the present disclosure; pharmaceutically acceptable salts thereof, deuterated forms thereof, isomers thereof, solvates thereof, and mixtures thereof. The compounds can be used for treating a patient suffering from a condition capable of treatment with a partial agonist or antagonist of the dopamine D2/D3 receptors and are especially useful for patients suffering from schizophrenia, depressions, neurodegenerative diseases such as Parkinson's, dyskinesias, substance abuse and relapse to substance abuse and addiction to substances such as cocaine, methamphetamine, nicotine and alcohol, glaucoma, cognitive disorders, restless leg syndrome, attention deficit hyperactivity disorders, hyperprolactinemia, autism, motor disturbances such as akathisia, rigor, dystonias as well as various disorders of the urinary tract and other neurologic disorders. Also provided are processes for the preparation of compounds of the present disclosure.

  本文提供了一种以公式表示的化合物：其中Y，Ri和R2在本公开中被定义；其药物可接受的盐，氘代形式，同分异构体，溶剂合物以及它们的混合物。这些化合物可用于治疗患有可用部分激动剂或拮抗剂治疗的病症的患者，尤其适用于患有精神分裂症，抑郁症，神经退行性疾病（如帕金森病），运动障碍，物质滥用和复发以及对可卡因，甲基苯丙胺，尼古丁和酒精等物质上瘾的患者，青光眼，认知障碍，不宁腿综合症，注意力缺陷多动症，高泌乳素血症，自闭症，运动障碍（如不安，僵硬，痉挛）以及各种泌尿道和其他神经疾病的病症。本文还提供了制备本公开化合物的方法。
• Azaallyl-Containing Moieties As Chelate For Metals
  申请人：Wolczanski Peter T.

  公开号：US20100204473A1

  公开（公告）日：2010-08-12

  The invention relates to di-aryl, di-heteroaryl or aryl-heteroaryl azaallyl compounds that are useful as chelates for metals.

  本发明涉及用作金属螯合剂的二芳基、二杂芳基或芳基-杂芳基氮杂烯化合物。
• Novel 2,2'-BI-1H-imidazoles
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0229922A2

  公开（公告）日：1987-07-29

  This invention relates to novel derivatives of 2,2'-bi-1H-imidazoles, to the processes and intermediates used in their preparation, to their ability to exert the pharmacologic effects of lowering high blood pressure and of increasing heart contractile force and to their use as chemotherapeutic agents useful in treating cardiac insufficiency and hypertension.

  本发明涉及 2,2'-bi-1H-咪唑的新型衍生物、制备过程和中间体、降低高血压和增加心脏收缩力的药理作用，以及用作治疗心功能不全和高血压的化疗药物。