methyl 6-O-(4-O-isobutyryl-β-D-glucopyranosyl)-2,3,4-tri-O-benzyl-α-D-glucopyranoside | 1194234-13-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 6-O-(4-O-isobutyryl-β-D-glucopyranosyl)-2,3,4-tri-O-benzyl-α-D-glucopyranoside
• 英文别名: isobutyryl(-4)Glc(b1-6)[Bn(-2)][Bn(-3)][Bn(-4)]a-Glc1Me；[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[[(2R,3R,4S,5R,6S)-6-methoxy-3,4,5-tris(phenylmethoxy)oxan-2-yl]methoxy]oxan-3-yl] 2-methylpropanoate
• CAS: 1194234-13-3
• 化学式: C₃₈H₄₈O₁₂
• 分子量: 696.792
• InChiKey: NOOUYACMZBGNKI-GRBWSTKQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  50
• 可旋转键数：
  17
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  152
• 氢给体数：
  3
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  methyl 2,3,4-tri-O-benzyl-6-O-(β-D-glucopyranosyl)-α-D-glucopyranoside 、 碳酸二异丙酯 在 2,4,6-三甲基吡啶 、 (2S,5S)-2,5-bis[[(2S)-3-(1H-indol-3-yl)-1-(octyloxy)-1-oxopropan-2-ylamino]carbonyl]-1-(pyridin-4-yl)pyrrolidine 作用下， 以 氯仿 为溶剂， 反应 12.0h， 生成 methyl 6-O-(4-O-isobutyryl-β-D-glucopyranosyl)-2,3,4-tri-O-benzyl-α-D-glucopyranoside
  参考文献：
  名称：

  Functional Group Tolerance in Organocatalytic Regioselective Acylation of Carbohydrates

  摘要：

  Organocatalytic regioselective acylation of mono- and disaccaharides with various functionalized acid anhydrides has been developed. Acylation Of octyl beta-D-glucopyranoside with acid anhydrides derived from alpha-amino acids, cinnamic acid, and gallic acid took place at C(4)-OH with 67-94% regioselectivity in the presence of catalyst 1. Regioselective acylation of disaccharides with functionalized acid anhydrides was also achieved with 78-94% selectivity. Especially, a disaccharide with seven free hydroxy groups (X = OH, R' = H) underwent acylation at C(4)-OH with 78% regioselectivity in the presence of 1. Thus, functional group tolerance in the regioselective acylation catalyzed by I was found to be high.

  DOI：

  10.1021/jo901569v

文献信息

• Functional Group Tolerance in Organocatalytic Regioselective Acylation of Carbohydrates
  作者：Yoshihiro Ueda、Wataru Muramatsu、Kenji Mishiro、Takumi Furuta、Takeo Kawabata

  DOI：10.1021/jo901569v

  日期：2009.11.20

  Organocatalytic regioselective acylation of mono- and disaccaharides with various functionalized acid anhydrides has been developed. Acylation Of octyl beta-D-glucopyranoside with acid anhydrides derived from alpha-amino acids, cinnamic acid, and gallic acid took place at C(4)-OH with 67-94% regioselectivity in the presence of catalyst 1. Regioselective acylation of disaccharides with functionalized acid anhydrides was also achieved with 78-94% selectivity. Especially, a disaccharide with seven free hydroxy groups (X = OH, R' = H) underwent acylation at C(4)-OH with 78% regioselectivity in the presence of 1. Thus, functional group tolerance in the regioselective acylation catalyzed by I was found to be high.