1-(2-bromophenyl)-3-(2-chlorophenyl)prop-2-yn-1-ol | 1296209-69-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1-(2-bromophenyl)-3-(2-chlorophenyl)prop-2-yn-1-ol
• CAS: 1296209-69-2
• 化学式: C₁₅H₁₀BrClO
• 分子量: 321.601
• InChiKey: QIBMUQNRZDHRMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-氯苯乙炔 、 邻溴苯甲醛 在 lithium tert-butoxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.83h， 以92%的产率得到1-(2-bromophenyl)-3-(2-chlorophenyl)prop-2-yn-1-ol
  参考文献：
  名称：

  ^tBuOLi-Mediated Alkynylation of Aldehydes

  摘要：

  [image omitted] The lithium tert-butoxide reagent was found to promote the addition of terminal aromatic alkynes to various aromatic aldehydes. This reaction was efficiently carried out in anhydrous dimethylformamide at room temperature in air for 50min, and the corresponding propargylic alcohols were obtained in good to excellent yields (up to 95%).

  DOI：

  10.1080/00397911.2010.481740

文献信息

• ^tBuOLi-Mediated Alkynylation of Aldehydes
  作者：Chuanbin Li、Xiaolong Li、Xu Meng、Tiansheng Wang、Jihui Li、Baohua Chen

  DOI：10.1080/00397911.2010.481740

  日期：2011.3.28

  [image omitted] The lithium tert-butoxide reagent was found to promote the addition of terminal aromatic alkynes to various aromatic aldehydes. This reaction was efficiently carried out in anhydrous dimethylformamide at room temperature in air for 50min, and the corresponding propargylic alcohols were obtained in good to excellent yields (up to 95%).