dimethyl (2S)-2-[2-[amino-[(2-methylpropan-2-yl)oxycarbonyl]amino]ethyl]cyclopropane-1,1-dicarboxylate | 1210525-83-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: dimethyl (2S)-2-[2-[amino-[(2-methylpropan-2-yl)oxycarbonyl]amino]ethyl]cyclopropane-1,1-dicarboxylate
• CAS: 1210525-83-9
• 化学式: C₁₄H₂₄N₂O₆
• 分子量: 316.354
• InChiKey: IIBMLCZQIZUNKQ-SECBINFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  dimethyl (2S)-2-[2-[amino-[(2-methylpropan-2-yl)oxycarbonyl]amino]ethyl]cyclopropane-1,1-dicarboxylate 在 ytterbium(III) triflate hydrate 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Stereodivergent Synthesis of Fused Bicyclopyrazolidines: Access to Pyrazolines and Pyrrolidines

  摘要：

  The reaction of hydrazinoethyl 1,1-cyclopropanediesters with aldehydes in the presence of catalytic Yb(OTf)(3) allows access to structurally complex fused bicyclo pyrazolidines. Either 2,5-cis or 2,5-trans adducts can be obtained in good to excellent yields in most cases by simply controlling the order of addition of the catalyst and aldehyde.

  DOI：

  10.1021/ol901744e
• 作为产物：
  描述：

  dimethyl (S)-2-(2-((tert-butoxycarbonyl)(1,3-dioxoisoindolin-2-yl)amino)ethyl)cyclopropane-1,1-dicarboxylate 在 乙醇 、 甲基肼 作用下， 以 二氯甲烷 为溶剂， 以97%的产率得到dimethyl (2S)-2-[2-[amino-[(2-methylpropan-2-yl)oxycarbonyl]amino]ethyl]cyclopropane-1,1-dicarboxylate
  参考文献：
  名称：

  Stereodivergent Synthesis of Fused Bicyclopyrazolidines: Access to Pyrazolines and Pyrrolidines

  摘要：

  The reaction of hydrazinoethyl 1,1-cyclopropanediesters with aldehydes in the presence of catalytic Yb(OTf)(3) allows access to structurally complex fused bicyclo pyrazolidines. Either 2,5-cis or 2,5-trans adducts can be obtained in good to excellent yields in most cases by simply controlling the order of addition of the catalyst and aldehyde.

  DOI：

  10.1021/ol901744e

文献信息

• Stereodivergent Synthesis of Fused Bicyclopyrazolidines: Access to Pyrazolines and Pyrrolidines
  作者：Terry P. Lebold、Michael A. Kerr

  DOI：10.1021/ol901744e

  日期：2009.10.1

  The reaction of hydrazinoethyl 1,1-cyclopropanediesters with aldehydes in the presence of catalytic Yb(OTf)(3) allows access to structurally complex fused bicyclo pyrazolidines. Either 2,5-cis or 2,5-trans adducts can be obtained in good to excellent yields in most cases by simply controlling the order of addition of the catalyst and aldehyde.