(2,2-dimethoxyethyl)(methyl)selane | 1187881-22-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2,2-dimethoxyethyl)(methyl)selane
• 英文别名: 2-(Methylseleno)acetaldehyde dimethylacetal；1,1-dimethoxy-2-methylselanylethane
• CAS: 1187881-22-6
• 化学式: C₅H₁₂O₂Se
• 分子量: 183.109
• InChiKey: QWVLXSPEBRWJNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.78
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-溴-1,1-二甲氧基乙烷 、 二甲基二硒醚 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 生成 (2,2-dimethoxyethyl)(methyl)selane
  参考文献：
  名称：

  Organoselenides from Nicotiana tabacum genetically modified to accumulate selenium

  摘要：

  Nicotiana tabacum L. (tobacco) plants were transformed to overexpress a selenocysteine methyltransferase gene from the selenium hyperaccumulator Astragalus bisulcatus (Hook.) A. Gray (two-grooved milk-vetch), and an ATP-sulfurylase gene from Brassica oleracea L. var. italica (broccoli). Solvent extraction of leaves harvested from plants treated with selenate revealed five selenium-containing compounds, of which four were identified by chemical synthesis as 2-(methylseleno)acetaldehyde, 2,2-bis(methylseleno)acetaldehyde, 4-(methylseleno)-(2E)-nonenal, and 4-(methylseleno)-(2E,6Z)-nonadienal. These four compounds have not previously been reported in nature. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.phytochem.2009.06.001

文献信息

• Selenoglucosinolates and their metabolites produced in Brassica spp. fertilised with sodium selenate
  作者：Adam J. Matich、Marian J. McKenzie、Ross E. Lill、David A. Brummell、Tony K. McGhie、Ronan K.-Y. Chen、Daryl D. Rowan

  DOI：10.1016/j.phytochem.2011.11.021

  日期：2012.3

  Glucosinolates are sulphur-containing glycosides found in many Brassica spp. that are important because their aglycone hydrolysis products protect the plant from herbivores and exhibit anti-cancer properties in humans. Recently, synthetically produced selenium analogues have been shown to be more effective at suppressing cancers than their sulphur counterparts. Although selenium is incorporated into a number of Brassica amino acids and peptides, firm evidence has yet to be presented for the presence of selenium in the glucosinolates and their aglycones in planta. In this study broccoli and cauliflower florets, and roots of forage rape, all obtained from plants treated with sodium selenate, were analysed for the presence of organoselenides. GC-MS analysis of pentane/ether extracts identified six organoselenium compounds including selenium analogues of known myrosinase-derived Brassica volatiles: 4-(methylseleno)butanenitrile, 5-(methylseleno)pentanenitrile, methylseleno)propylisothiocyanate, 4-(methylseleno)butylisothiocyanate, and 5-(methylseleno)pentylisothiocyanate. LC-MS analysis of ethanolic extracts identified three selenoglucosinolates: methylseleno)propylglucosinolate (glucoselenoiberverin), 4-(methylseleno)butylglucosinolate (glucoselenoerucin), and 5-(methylseleno)pentylglucosinolate (glucoselenoberteroin). LC-MS/MS analysis was used to locate the position of the selenium atom in the selenoglucosinolate and indicates preferential incorporation of selenium via selenomethionine into the methylselenyl moiety rather than into the sulphate or 0-thioglucose groups. In forage rape, selenoglucosinolates and their aglycones (mainly isothiocyanates), occurred at concentrations up to 10% and 70%, respectively, of their sulphur analogues. In broccoli, concentrations of the selenoglucosinolates and their aglycones (mainly nitriles) were up to 60% and 1300%, respectively of their sulphur analogues. These findings indicate the potential for the incorporation of high levels of selenium into Brassica glucosinolates. (C) 2011 Elsevier Ltd. All rights reserved.
• Organoselenides from Nicotiana tabacum genetically modified to accumulate selenium
  作者：Adam J. Matich、Marian J. McKenzie、David A. Brummell、Daryl D. Rowan

  DOI：10.1016/j.phytochem.2009.06.001

  日期：2009.6

  Nicotiana tabacum L. (tobacco) plants were transformed to overexpress a selenocysteine methyltransferase gene from the selenium hyperaccumulator Astragalus bisulcatus (Hook.) A. Gray (two-grooved milk-vetch), and an ATP-sulfurylase gene from Brassica oleracea L. var. italica (broccoli). Solvent extraction of leaves harvested from plants treated with selenate revealed five selenium-containing compounds, of which four were identified by chemical synthesis as 2-(methylseleno)acetaldehyde, 2,2-bis(methylseleno)acetaldehyde, 4-(methylseleno)-(2E)-nonenal, and 4-(methylseleno)-(2E,6Z)-nonadienal. These four compounds have not previously been reported in nature. (C) 2009 Elsevier Ltd. All rights reserved.