1-(4-chloro-phenyl)-3-(4-ethyl-phenyl)-propenone | 782483-60-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1-(4-chloro-phenyl)-3-(4-ethyl-phenyl)-propenone
• 英文别名: 1-(4-Chlorophenyl)-3-(4-ethylphenyl)prop-2-en-1-one
• CAS: 782483-60-7
• 化学式: C₁₇H₁₅ClO
• 分子量: 270.758
• InChiKey: PIYBYVAIWMVDSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-[(4-hydrazino-benzenesulfonyl)-methyl-amino]-3-phenyl-propionic acid ethyl ester 、 1-(4-chloro-phenyl)-3-(4-ethyl-phenyl)-propenone 以 乙醇 为溶剂， 反应 4.0h， 以78%的产率得到2-({4-[3-(4-chloro-phenyl)-5-(4-ethyl-phenyl)-4,5-dihydro-pyrazol-1-yl]-benzenesulfonyl}-methyl-amino)-3-phenyl-propionic acid ethyl ester
  参考文献：
  名称：

  [EN] N- (((((1,3-THIAZOL-2-YL) AMINO) CARBONYL) PHENYL) SULFONYL) PHENYLALANINE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF DIABETES
  [FR] ACIDES PHENYLALCANOIQUES SUBSTITUES

  摘要：

  公开号：

  WO2004092146A3
• 作为产物：
  描述：

  对氯苯乙酮 、 4-乙基苯甲醛 在 sodium methylate 、 盐酸 作用下， 以 甲醇 、 水 为溶剂， 反应 16.0h， 以98%的产率得到1-(4-chloro-phenyl)-3-(4-ethyl-phenyl)-propenone
  参考文献：
  名称：

  [EN] N- (((((1,3-THIAZOL-2-YL) AMINO) CARBONYL) PHENYL) SULFONYL) PHENYLALANINE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF DIABETES
  [FR] ACIDES PHENYLALCANOIQUES SUBSTITUES

  摘要：

  公开号：

  WO2004092146A3

文献信息

• Substituted phenylalkanoic acids for the treatment of diabetes
  申请人：The Institute for Pharmaceutical Discovery LLC

  公开号：US20040248937A1

  公开（公告）日：2004-12-09

  The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): 1 which are useful in the treatment of metabolic disorders related to insulin resistance or hyperglycemia. These compounds include inhibitors of protein tyrosine phosphatase (PTP-1B) that are useful in the treatment of diabetes and other PTP-1B mediated diseases, such as cancer, neurodegenerative diseases and the like. The compounds of the invention are also useful in pharmaceutical compositions and methods of treating the aforementioned conditions.

  本发明涉及以下式(I)的化合物和药用盐：1，这些化合物在治疗与胰岛素抵抗或高血糖相关的代谢紊乱方面具有用处。这些化合物包括蛋白酪氨酸磷酸酶（PTP-1B）的抑制剂，对于治疗糖尿病和其他PTP-1B介导的疾病（如癌症、神经退行性疾病等）具有用处。本发明的化合物还可用于制备药物组合物和治疗上述疾病的方法。
• N-(((((1,3-THIAZOL-2-YL)AMINO)CARBONYL)PHENYL)SULFONYL)PHENYLALANINE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF DIABETES
  申请人：The Institutes for Pharmaceutical Discovery, LLC

  公开号：EP1633354A2

  公开（公告）日：2006-03-15
• [EN] SUBSTITUTED PHENYLALKANOIC ACIDS<br/>[FR] ACIDES PHENYLALCANOIQUES SUBSTITUES
  申请人：INST FOR PHARM DISCOVERY INC

  公开号：WO2004092146A2

  公开（公告）日：2004-10-28

  The present invention relates to compounds and pharmaceutically acceptable salts of formula (I), which are useful in the treatment of metabolic disorders related to insulin resistance or hyperglycemia. These compounds include inhibitors of protein tyrosine phosphatase (PTP-1B) that are useful in the treatment of diabetes and other PTP-1B mediated diseases, such as cancer, neurodegenerative diseases and the like. The compounds of the invention are also useful in pharmaceutical compositions and methods of treating the aforementioned conditions.