N-Methyl-N-<(p-formylphenoxy)-2-ethyl>aniline | 134539-18-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-Methyl-N-<(p-formylphenoxy)-2-ethyl>aniline
• 英文别名: 4-[2-(N-Methyl-N-phenylamino)ethoxy]benzaldehyde；4-[2-(N-methylanilino)ethoxy]benzaldehyde
• CAS: 134539-18-7
• 化学式: C₁₆H₁₇NO₂
• 分子量: 255.316
• InChiKey: OKHXEZPLMQHQFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  肌氨酸 、 足球烯 、 N-Methyl-N-<(p-formylphenoxy)-2-ethyl>aniline 以 甲苯 为溶剂， 反应 10.0h， 以58%的产率得到
  参考文献：
  名称：

  Excited-State Interactions in Pyrrolidinofullerenes

  摘要：

  Two new pyrrolidinofullerenes, 1 and 2, have been synthesized, and their photophysical properties have been investigated. The pyrrolidinofullerene 1 has three phenyl groups attached to the 1, 2, and 5 positions of the pyrrolidine ring. The pyrrolidinofullerene 2, on the other hand, has a flexible attachment with an N-methylaniline end group and is the prototype of a fullerene-aniline dyed. Singlet and triplet excited-state properties of these two functionalized fullerene derivatives have been examined with picosecond and nanosecond laser flash photolysis. The singlet and triplet excited states of these fullerenes exhibit characteristic absorption bands in the vis-IR region of the spectrum. The functionalization of C-60 with pyrrolidine groups shift the excited-state absorption maxima to the blue. Three different quenchers, O-2, TEMPO, and ferrocene, are employed to investigate the reactivity of triplet excited states. The bimolecular quenching rate constants determined for these quenchers were in the range of 5.3 x 10(8) to 7.7 x 10(9) M-1 s(-1). The excited-state interactions of these functionalized fullerenes are compared to that of C-60.

  DOI：

  10.1021/jp972756z
• 作为产物：
  描述：

  N-甲基-N-羟乙基苯胺 在 三溴化磷 、 potassium carbonate 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 15.0h， 生成 N-Methyl-N-<(p-formylphenoxy)-2-ethyl>aniline
  参考文献：
  名称：

  Excited-State Interactions in Pyrrolidinofullerenes

  摘要：

  Two new pyrrolidinofullerenes, 1 and 2, have been synthesized, and their photophysical properties have been investigated. The pyrrolidinofullerene 1 has three phenyl groups attached to the 1, 2, and 5 positions of the pyrrolidine ring. The pyrrolidinofullerene 2, on the other hand, has a flexible attachment with an N-methylaniline end group and is the prototype of a fullerene-aniline dyed. Singlet and triplet excited-state properties of these two functionalized fullerene derivatives have been examined with picosecond and nanosecond laser flash photolysis. The singlet and triplet excited states of these fullerenes exhibit characteristic absorption bands in the vis-IR region of the spectrum. The functionalization of C-60 with pyrrolidine groups shift the excited-state absorption maxima to the blue. Three different quenchers, O-2, TEMPO, and ferrocene, are employed to investigate the reactivity of triplet excited states. The bimolecular quenching rate constants determined for these quenchers were in the range of 5.3 x 10(8) to 7.7 x 10(9) M-1 s(-1). The excited-state interactions of these functionalized fullerenes are compared to that of C-60.

  DOI：

  10.1021/jp972756z

文献信息

• Compounds
  申请人：Beecham Group p.l.c.

  公开号：US05132317A1

  公开（公告）日：1992-07-21

  A compound of formula (I): ##STR1## or a tautomeric form thereof and/or a pharmaceutically acceptable salt thereof, and/or a pharmaceutically acceptable solvate thereof, wherein: A.sup.1 represents a substituted or unsubstituted aryl group; A.sup.2 represents a benzene ring having in total up to five substituents; X represents O, S or NR.sup.1 wherein R.sup.1 represents a hydrogen atom, an alkyl group, an acyl group, an aralkyl group, wherein the aryl moiety may be substituted or unsubstituted, or a substituted or unsubstituted aryl group; Y represents O or S; R.sup.2 represents hydrogen; R.sup.3 represents hydrogen or an alkyl, aralkyl or aryl group or R.sup.2 together with R.sup.3 represents a bond; and n represents an integer in the range of from 2 to 6; a process for preparing such a compound, a pharmaceutical composition comprising such a compound and the use of such compound and composition in medicine.

  式(I)的化合物：##STR1## 或其互变异构体和/或药学上可接受的盐和/或药学上可接受的溶剂化物，其中：A.sup.1代表取代或未取代的芳基基团；A.sup.2代表总共最多有五个取代基的苯环；X代表O、S或NR.sup.1，其中R.sup.1代表氢原子、烷基、酰基、芳基烷基，其中芳基基团可以是取代或未取代的，或者是取代或未取代的芳基基团；Y代表O或S；R.sup.2代表氢原子；R.sup.3代表氢原子或烷基、芳基烷基或芳基基团，或者R.sup.2和R.sup.3一起代表键；n代表在2到6之间的整数；制备这样的化合物的方法、包含这样的化合物的制药组合物以及这样的化合物和组合物在医学上的用途。
• METFORMIN SALTS TO TREAT TYPE2 DIABETES
  申请人：JIVA PHARMA, INC.

  公开号：US20160229796A1

  公开（公告）日：2016-08-11

  Metformin salts of 2,4-thiazolidinediones are described for the treatment of diabetes mellitus Type2, gestational diabetes, polycystic ovary syndrome, non-alcoholic fatty liver disease, coronary artery disease, pancreatic cancer, premature puberty, and other diseases which manifest insulin resistance.

  本文介绍了2,4-噻唑烷二酮的甲双胍盐，用于治疗2型糖尿病、妊娠期糖尿病、多囊卵巢综合症、非酒精性脂肪肝病、冠状动脉疾病、胰腺癌、早发性青春期和其他表现胰岛素抵抗的疾病。
• Thiazolidinedione derivatives
  申请人：Beecham Group p.l.c.

  公开号：EP0415605A1

  公开（公告）日：1991-03-06

  A compound of formula (I): or a tautomeric form thereof and/or a pharmaceutically acceptable salt thereof, and/or a pharmaceutically acceptable solvate thereof, wherein: A¹ represents a substituted or unsubstituted aryl group; A² represents a benzene ring having in total up to five substituents; X represents O, S or NR¹ wherein R¹ represents a hydrogen atom, an alkyl group, an acyl group, an aralkyl group, wherein the aryl moiety may be substituted or unsubstituted, or a substituted or unsubstituted aryl group; Y represents O or S; R² represents hydrogen; R³ represents hydrogen or an alkyl, aralkyl or aryl group or R² together with R³ represents a bond; and n represents an integer in the range of from 2 to 6; a process for preparing such a compound, a pharmaceutical composition comprising such a compound and the use of such compound and composition in medicine.

  式(I)化合物 或其同分异构体和/或其药学上可接受的盐和/或其药学上可接受的溶液，其中 A¹ 代表取代或未取代的芳基； A² 代表总共具有最多五个取代基的苯环； X代表O、S或NR¹，其中R¹代表氢原子、烷基、酰基、芳烷基，其中芳基可以是取代或未取代的，或取代或未取代的芳基； Y 代表 O 或 S R² 代表氢 R³ 代表氢或烷基、芳基或芳基，或 R² 与 R³ 一起代表键；以及 n 代表 2 至 6 范围内的整数；制备这种化合物的工艺、包含这种化合物的药物组合物以及这种化合物和组合物在医药中的用途。
• US5132317A
  申请人：——

  公开号：US5132317A

  公开（公告）日：1992-07-21
• US9815777B2
  申请人：——

  公开号：US9815777B2

  公开（公告）日：2017-11-14