3-(1-aminoethylidene)pentane-2,4-dione | 73845-28-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(1-aminoethylidene)pentane-2,4-dione
• 英文别名: Hampd
• CAS: 73845-28-0
• 化学式: C₇H₁₁NO₂
• mdl: MFCD18812350
• 分子量: 141.17
• InChiKey: UNAZCSFKIMJAKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.38
• 重原子数：
  10.0
• 可旋转键数：
  2.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  60.16
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  3-(1-aminoethylidene)pentane-2,4-dione 在 盐酸 作用下， 生成 4-氨基-3-戊烯-2-酮
  参考文献：
  名称：

  Reactions of β-diketone compounds with nitriles catalyzed by Lewis acids: a simple approach to β-enaminone synthesis

  摘要：

  氯化铝选择性促进了β-二酮化合物与腈的亲核进攻，生成烯酮。

  DOI：

  10.1039/c4ra10879e
• 作为产物：
  描述：

  triacetylmethane 在 六甲基二硅氮烷 作用下， 以 氯仿 为溶剂， 反应 48.0h， 以80%的产率得到3-(1-aminoethylidene)pentane-2,4-dione
  参考文献：
  名称：

  Chu, Daniel T. W.; Huckin, Stuart N., Canadian Journal of Chemistry, 1980, vol. 58, p. 138 - 142

  摘要：

  DOI：

文献信息

• [EN] CYCLIC DIARYLBORON DERIVATIVES AS NLRP3 INFLAMMASOME INHIBITORS<br/>[FR] DÉRIVÉS DE DIARYLBORON CYCLIQUES UTILISÉS EN TANT QU'INHIBITEURS D'INFLAMMASOME NLRP3
  申请人：UNIV MANCHESTER

  公开号：WO2017017469A1

  公开（公告）日：2017-02-02

  Inhibitor compounds are disclosed. The compounds are effective in the treatment of diseases or conditions in which interleukin 1 β activity is implicated. Methods of synthesis of the compounds, as well as pharmaceutical compositions comprising the compounds are also disclosed.

  抑制剂化合物已被披露。这些化合物在治疗与白细胞介素1β活性有关的疾病或症状中具有有效性。此外，还披露了合成这些化合物的方法，以及包含这些化合物的药物组合物。
• Cyclic diarylboron derivatives as NLRP3 inflammasome inhibitors
  申请人：The University of Manchester

  公开号：US10570157B2

  公开（公告）日：2020-02-25

  Inhibitor compounds are disclosed. The compounds are effective in the treatment of diseases or conditions in which interleukin 1 β activity is implicated. Methods of synthesis of the compounds, as well as pharmaceutical compositions comprising the compounds are also disclosed.

  本研究公开了抑制剂化合物。这些化合物可有效治疗白细胞介素 1 β 活性相关的疾病或病症。此外，还公开了这些化合物的合成方法以及包含这些化合物的药物组合物。
• Coordinating properties of the anionic ligand (MeCO)2C(−)C(X)Me (X=O or NH) toward transition metal(II) centers
  作者：Marino Basato、Elisabetta Caneva、Cristina Tubaro、Augusto Cesare Veronese

  DOI：10.1016/j.ica.2008.11.017

  日期：2009.6

  The exchange reaction between transition metal(II) acetates and the protic nucleophiles 3-(1-aminoethylidene) pentane-2,4-dione (Hampd) or 3-acetylpentane-2,4-dione (Hacpd) affords the corresponding [M(ampd)(2)] (M = Ni (1), Pd (2)) or [M(acpd)(2)] (M = Mn (5), Fe (6), Ni (7), Cu (8), Pd (9)) complexes in fair to good yields. The reaction is performed in ethanol at room temperature, with addition of sodium carbonate in some cases. This last new synthetic procedure is applied for those complexes which easily undergo an extensive deacylation process. The factors determining the success of the exchange reaction and the resulting N, O or O, O coordination are fully discussed. (C) 2008 Elsevier B.V. All rights reserved.
• CYCLIC DIARYLBORON DERIVATIVES AS NLRP3 INFLAMMASOME INHIBITORS
  申请人：The University of Manchester

  公开号：EP3328868A1

  公开（公告）日：2018-06-06
• Reactions of β-diketone compounds with nitriles catalyzed by Lewis acids: a simple approach to β-enaminone synthesis
  作者：Xu Cheng、Shuchen Pei、Chenchen Xue、Kaifei Cao、Li Hai、Yong Wu

  DOI：10.1039/c4ra10879e

  日期：——

  Aluminium chloride selectively promoted the nucleophilic attack of β-diketone compounds with nitriles to give enaminones.

  氯化铝选择性促进了β-二酮化合物与腈的亲核进攻，生成烯酮。