环丙嘧啶酸 | 858956-08-8

• 物质功能分类: 医药中间体 - 杂环化合物 - 嘧啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 环丙嘧啶酸
• 中文别名: 6-氨基-5-氯-2-环丙基嘧啶-4-羧酸；6-氨基-5-氯代-2-环丙基嘧啶-4-羧酸(IUPAC)、6-氨基-5-氯-2-环丙基-4-嘧啶羧酸(CA)；6-氨基-5-氯-2-环丙基嘧啶-4-甲酸；氯丙嘧啶酸
• 英文名称: aminocyclopyrachlor
• 英文别名: 6-amino-5-chloro-2-cyclopropyl-4-pyrimidinecarboxylic acid；6-amino-5-chloro-2-cyclopropylpyrimidine-4-carboxylic acid
• CAS: 858956-08-8
• 化学式: C₈H₈ClN₃O₂
• 分子量: 213.623
• InChiKey: KWAIHLIXESXTJL-UHFFFAOYSA-N

物化性质

• 熔点：
  215 - 217°C
• 沸点：
  432.3±45.0 °C(Predicted)
• 密度：
  1.635±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）
• LogP：
  -2.48--1.01 at 20℃
• 表面张力：
  72.1mN/m at 885mg/L and 20℃
• 解离常数：
  4.65 at 20℃
• 颜色/状态：
  Granules
• 蒸汽压力：
  3.7X10-8 mm Hg at 25 °C

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  89.1
• 氢给体数：
  2
• 氢受体数：
  5

ADMET

代谢

一只雄性和一只雌性大鼠通过单次口服灌胃方式接受了25 mg/kg剂量的(14)C-DPX-KJM44（氨基环吡咯甲酸甲酯）。动物被放置在玻璃代谢单元中，以收集14C呼出的挥发性物质和(14)CO2，持续48小时（每隔24小时）。尿液和粪便也在干冰上以24小时为间隔收集，持续168小时。通过液闪计数（LSC）、高效液相色谱（HPLC）和质谱（MS）分析，对尿液、粪便、组织、尸体、笼具清洗液和残余饲料中的放射性进行了量化。在单次25 mg/kg剂量后的48小时内，呼吸气体中未检测到放射性。尿液是放射性排泄的主要途径，168小时内雄性和雌性大鼠分别有80.4%和79.3%的给药剂量被检测到（大部分（78.8%，两个性别）在给药后前24小时内排出）。在168小时内，雄性和雌性大鼠粪便中的放射性分别为6.67%和3.06%，其中大部分在治疗后48小时内排出（雄性5.6%，雌性2.8%）。笼具清洗液和残余饲料中的放射性分别为雄性2.0%和雌性0.1%。168小时后，雄性和雌性的总体物质平衡分别为89.2%和82.6%。组织中的14C残留物通常低于定量限，除了雄性和雌性尸体中分别含有0.144%和0.121%的给药剂量，以及雄性胃肠道和内容物中总共含有0.009%的剂量。DPX-MAT28（氨基环吡咯）是尿液中唯一被识别的代谢物（两个性别均为78.8%的给药剂量）和粪便中（雄性4.57%，雌性1.72%的剂量）。氨基环吡咯甲酸甲酯

1 male and 1 female rat received a single oral gavage dose of (14)C-DPX-KJM44 /aminocyclopyrachlor methyl/ at 25 mg/kg. Animals were placed in glass metabolism units for collection of 14C exhaled volatiles and (14)CO2 for 48 hours (at 24-hour intervals). Urine and feces were also collected at 24-hour intervals over dry ice for 168 hours. Radioactivity was quantified in urine, feces, tissues, carcass, cage wash, and residual feed and urine and feces were also analyzed for metabolites (LSC, HPLC, mass spectrometry (MS)). Radioactivity was not detected in respired breath during 48 hours after a single 25 mg/kg dose. Urine was the main route of excretion of radioactivity with 80.4% (male) and 79.3% (female) of administered dose detected during 168 hours post-dosing (most (78.8% for both sexes) was excreted during the first 24 hours after dosing). 6.67% (male) and 3.06% (female) of administered radioactivity was found in feces during 168 hours with the majority excreted during 48 hours post-treatment (5.6% (male) and 2.8% (female)). Radioactivity detected in cage wash and residual food was 2.0% and 0.1% for the male and female, respectively. The overall material balance was 89.2% (male) and 82.6% (female) after 168 hours. 14C residues in tissues were generally below the limit of quantification except male and female carcasses contained 0.144% and 0.121% of administered dose, respectively, and the male gastrointestinal tract and contents contained 0.009% of dose combined. DPX-MAT28 /aminocyclopyrachlor/ was the only metabolite identified in urine (78.8% of administered dose for both sexes) and feces (4.57% (males) and 1.72% (females) of dose). /Aminocyclopyrachlor-methyl/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 立即急救：确保已经进行了充分的中和。如果患者停止呼吸，请开始人工呼吸，最好使用需求阀复苏器、球囊阀面罩设备或口袋面罩，按训练操作。如有必要，执行心肺复苏。立即用缓慢流动的水冲洗受污染的眼睛。不要催吐。如果患者呕吐，让患者向前倾或将其置于左侧（如果可能的话，头部向下）以保持呼吸道畅通，防止吸入。保持患者安静，维持正常体温。寻求医疗救助。 /毒物A和B/

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 基本治疗：建立专利气道（如有需要，使用口咽或鼻咽气道）。如有必要，进行吸痰。观察呼吸不足的迹象，如有需要，辅助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，如有必要，进行治疗……。监测休克，如有必要，进行治疗……。预防癫痫发作，如有必要，进行治疗……。对于眼睛污染，立即用水冲洗眼睛。在运输过程中，用0.9%的生理盐水（NS）持续冲洗每只眼睛……。不要使用催吐剂。对于摄入，如果患者能吞咽、有强烈的干呕反射且不流口水，则用温水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释……。在去污后，用干燥的无菌敷料覆盖皮肤烧伤……。/毒药A和B/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 高级治疗：对于无意识、严重肺水肿或严重呼吸困难的病人，考虑进行口咽或鼻咽气管插管以控制气道。使用气囊面罩装置的正压通气技术可能有益。考虑使用药物治疗肺水肿……。对于严重的支气管痉挛，考虑给予β激动剂，如沙丁胺醇……。监测心率和必要时治疗心律失常……。开始静脉输注D5W /SRP: "保持开放"，最小流量/。如果出现低血容量的迹象，使用0.9%的生理盐水（NS）或乳酸林格氏液。对于伴有低血容量迹象的低血压，谨慎给予液体。注意液体过载的迹象……。使用地西泮或劳拉西泮治疗癫痫……。使用丙美卡因氢氯化物协助眼部冲洗……。 /Poisons A and B/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

皮肤去污。皮肤污染应立即用肥皂和水清洗处理。眼睛污染应立即用大量清水长时间冲洗。如果皮肤或眼睛刺激持续存在，应立即获得医疗注意。/其他除草剂/

Skin decontamination. Skin contamination should be treated promptly by washing with soap and water. Contamination of the eyes should be treated immediately by prolonged flushing of the eyes with large amounts of clean water. If dermal or ocular irritation persists, medical attention should be obtained without delay. /Other herbicides/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

胃肠道去污。摄入这些除草剂后可能会出现呕吐和腹泻，这是由于它们的刺激性特性。管理取决于：（1）摄入量的最佳估计，（2）摄入后经过的时间，（3）受试者的临床状况。活性炭可能有效于限制刺激性效果并减少大部分或所有这些除草剂的吸收。氢氧化铝抗酸剂可能有助于中和更酸性物质的刺激性作用。如果肠道有声音且自发腹泻尚未开始，应给予山梨醇以诱导泻药。脱水和电解质紊乱可能严重到需要口服或静脉输液的程度。... 如果摄入了大量除草剂，并且患者在摄入后一小时内就诊，应考虑胃肠道去污。... 如果摄入的除草剂量较小，如果已经发生了有效的呕吐，或者如果治疗延迟，通过口腔给予活性炭和山梨醇。/其他除草剂/

Gastrointestinal decontamination. Ingestions of these herbicides are likely to be followed by vomiting and diarrhea due to their irritant properties. Management depends on: (1) the best estimate of the quantity ingested, (2) time elapsed since ingestion, and (3) the clinical status of the subject. Activated charcoal is probably effective in limiting irritant effects and reducing absorption of most or all of these herbicides. Aluminum hydroxide antacids may be useful in neutralizing the irritant actions of more acidic agents. Sorbitol should be given to induce catharsis if bowel sounds are present and if spontaneous diarrhea has not already commenced. Dehydration and electrolyte disturbances may be severe enough to require oral or intravenous fluids. ... If large amounts of herbicide have been ingested and the patient is seen within an hour of the ingestion, gastrointestinal decontamination should be considered ... . If the amount of ingested herbicides was small, if effective emesis has already occurred, or if treatment is delayed, administer activated charcoal and sorbitol by mouth. /Other herbicides/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

每组的每性别4只老鼠，通过手术植入颈静脉导管，单次口服给予(14)C-DPX-MAT28/氨环吡啶氯/25毫克/千克和500毫克/千克的剂量，并被放置在代谢笼中。在治疗前和给药后5、15、30分钟以及1、2、4、8、12、24和30小时从颈静脉导管收集系列血液样本。血浆中含有的(14)C残留物浓度在治疗后长达30小时可量化。两组平均血浆半衰期在25毫克/千克和500毫克/千克时，雄性(5.6小时)和雌性(5.7小时)几乎相同。25毫克/千克时，组平均血浆峰值浓度(Cmax)雄性为3.8微克当量/克，雌性为5.0微克当量/克；500毫克/千克时，雄性为57.3微克当量/克，雌性为61.6微克当量/克（剂量增加20倍时，Cmax增加12到15倍）。25毫克/千克时，达到血浆峰值浓度的时间(Tmax)雄性为0.5小时，雌性为0.4小时；500毫克/千克时，雄性为0.6小时，雌性为1.0小时。血浆的组平均曲线下面积值(AUCINF)在25毫克/千克时，雄性为7.0小时*微克/克，雌性为9.0小时*微克/克；500毫克/千克时，雄性为151小时*微克/克，雌性为168小时*微克/克（相对于低剂量值，雄性增加了21.5倍，雌性增加了18倍）。25毫克/千克时，红细胞组平均Cmax值为雄性1.3微克当量/克，雌性2.0微克当量/克；500毫克/千克时，雄性为27.2微克当量/克，雌性为28.7微克当量/克。25毫克/千克时，红细胞的组平均Tmax值为雄性0.5小时，雌性0.3小时；在高剂量时，雄性为0.6小时，雌性为1.0小时。

4 rats per sex per group with surgically implanted jugular vein cannulas received a single oral gavage dose of (14)C-DPX-MAT28 /aminocyclopyrachlor/ at 25 and 500 mg/kg and were placed in metabolism cages. Serial blood samples were collected pre-treatment and at 5, 15, and 30 minutes, and 1, 2, 4, 8, 12, 24, and 30 hours post-dosing from the jugular vein cannula. Plasma contained quantifiable concentrations of (14)C residues for up to 30 hours post-treatment. Group mean plasma half-lives were nearly identical for males (5.6 hours) and females (5.7 hours) at both 25 and 500 mg/kg. Group mean peak plasma concentrations (Cmax) were 3.8 ug.equiv/g for males and 5.0 ug.equiv/g for females at 25 mg/kg and 57.3 ug.equiv/g for males and 61.6 ?g.equiv/g for females at 500 mg/kg (a 12 to 15 fold increase in Cmax with the 20-fold increase in dose). Times to peak plasma concentrations (Tmax) were 0.5 hours (males) and 0.4 hours (females) at 25 mg/kg and 0.6 hours (males) to 1.0 hours (females) at 500 mg/kg. Group mean area under the curve values (AUCINF) for plasma were 7.0 hr*ug/g for males and 9.0 hr*ug/g for females at 25 mg/kg and 151 hr*ug/g for males and 168 hr*ug/g for females at 500 mg/kg (21.5 (males) and 18 (females) fold increases over the low dose values). Group mean Cmax values for red blood cells were 1.3 ug.equiv/g for males and 2.0 ug.equiv/g for females at 25 mg/kg and 27.2 ug.equiv/g for males and 28.7 ug.equiv/g for females at 500 mg/kg. Group mean Tmax values for RBCs were 0.5 hour (males) and 0.3 hour (females) at 25 mg/kg and 0.6 hour for males and 1.0 hour for females at the high dose.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

每性别3只大鼠单次口服给予500 mg/kg的(14)C-DPX-MAT28/氨环吡啶氯/。治疗后30分钟处死大鼠，收集全血并分离成血浆和红细胞。此外，每性别使用1只大鼠收集对照血浆。血浆中唯一可识别的成分是DPX-MAT28，男性组平均浓度为219 uM，女性组为251 uM。未表明有生物转化。DPX-MAT28在血浆中循环，并以完整的母体化学物质形式在尿液和粪便中排出。

3 rats per sex received a single oral gavage dose of (14)C-DPX-MAT28 /aminocyclopyrachlor/ at 500 mg/kg. Rats were sacrificed 30 minutes post-treatment and whole blood was collected and separated into plasma and erythrocytes. Additionally, 1 rat per sex was used for collection of control plasma. The only identifiable component in plasma was DPX-MAT28 at group mean concentrations of 219 uM for males and 251 uM for females. No biotransformation was indicated. DPX-MAT28 circulated in plasma and was excreted in the urine and feces as intact parent chemical

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

每只性别的大鼠口服给予单剂量的(14)C-DPX-MAT28 /氨基环吡啶甲酸酯/，剂量为25 mg/kg。动物被放置在玻璃代谢装置中，以收集48小时内的(14)C呼出挥发性物质和(14)CO2（每隔24小时）。尿液和粪便也在干冰上以24小时为间隔收集168小时。尿液、粪便、组织、尸体、笼子清洗液和剩余饲料被分析（液闪计数、高效液相色谱、质谱（MS）），以确定初步的物质平衡和组织分布（尿液和粪便分析代谢物）。在单次25 mg/kg剂量后的48小时内，呼出气中未检测到放射性。放射性在尿液和粪便中都有排出，大部分在给药后第一个24小时内排出。在处理后168小时内，36.3%（雄性）和55.8%（雌性）的给药剂量通过尿液排出，32.1%（雄性）和51.7%（雌性）通过粪便排出（24小时的值分别为35.9%（雄性）和53.7%（雌性）在尿液中，31.1%（雄性）和48.0%（雌性）在粪便中）。168小时后的总体物质平衡为69.9%（雄性）和107.9%（雌性）。除了雄性尸体含有0.039%的给药剂量外，组织中的(14)C残留物通常低于定量限。DPX-MAT28是尿液中（35.9%（雄性）和53.7%（雌性）的给药剂量）和粪便中（31.1%（雄性）和48.0%（雌性）的剂量）唯一被识别的成分。

One rat per sex received a single oral gavage dose of (14)C-DPX-MAT28 /aminocyclopyrachlor/ at 25 mg/kg. Animals were placed in glass metabolism units for collection of (14)C exhaled volatiles and (14)CO2 for 48 hours (at 24-hour intervals). Urine and feces were also collected at 24-hour intervals over dry ice for 168 hours. Urine, feces, tissues, carcass, cage wash, and residual feed were analyzed (LSC, HPLC, mass spectrometry (MS)) to determine preliminary material balance and tissue distribution (urine and feces were analyzed for metabolites). Radioactivity was not detected in respired breath during 48 hours after a single 25 mg/kg dose. Excretion of radioactivity occurred in both urine and feces with the majority eliminated during the first 24 hours after dosing. During 168 hours post-treatment, 36.3% (male) and 55.8% (female) of administered dose was excreted in urine and 32.1% (male) and 51.7% (female) was eliminated in feces (24 hour values were 35.9% (male) and 53.7% (female) in urine and 31.1% (male) and 48.0% (female) in feces). The overall material balance was 69.9% (male) and 107.9% (female) after 168 hours. (14)C residues in tissues were generally below the limit of quantification except the male carcass contained 0.039% of administered dose. DPX-MAT28 was the only component identified in urine (35.9% (males) and 53.7% (females) of administered dose) and feces (31.1% (males) and 48.0% (females) of dose).

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 海关编码：
  2933599020
• 储存条件：
  -20°C，避光、干燥、密封保存。

制备方法与用途

作用机理

环丙嘧啶酸属于生物合成的激素类除草剂，通过叶面喷施进入植物体内，并具有内吸活性。它可以通过叶片、茎秆和根部被吸收并传导至木质部和韧皮部，导致杂草死亡通常需要几周到几个月的时间，效果显著。

适用作物

环丙嘧啶酸及其甲酯主要用于非农用作物，包括裸地、公路、草坪、牧场作物等。

防治对象

环丙嘧啶酸主要防治阔叶杂草，包括菊科、豆科、藜科、旋花科、茄科、大戟科及一些木本植物，如红糖槭、榉叶槭、朴木、白柳、美国多花蓝果树、牧豆树和美国榆等。

使用方法

推荐使用剂量为70～350克/公顷。环丙嘧啶酸对那些对草甘膦和ALS抑制剂产生抗性的杂草（如杉叶藻、地肤、莴苣等）也有很好的防效，能有效帮助土地管理者控制构成火警危险或阻碍交通运输和公用事业关键通道的杂草和灌木。此外，环丙嘧啶酸使用剂量低，可与磺酰脲类除草剂混用，以扩大杂草防治范围。

反应信息

• 作为反应物：
  描述：

  环丙嘧啶酸 、 溴甲烷 在 三正丁胺 作用下， 以 二甲基亚砜 为溶剂， 反应 3.5h， 以81%的产率得到6-氨基-5-氯-2-环丙基嘧啶-4-甲酸甲酯
  参考文献：
  名称：

  WO2006/121648

  摘要：

  公开号：
• 作为产物：
  描述：

  2-cyclopropyl-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid 在 盐酸 、 sodium hypochlorite 、 氨 、 三氯氧磷 作用下， 以 水 为溶剂， 反应 7.0h， 生成 环丙嘧啶酸
  参考文献：
  名称：

  Fatty Amine Salts Of Herbicidal Pyrimidines

  摘要：

  这项发明涉及（1）通过将下面给出的式I所披露的一个或多个化合物的酸形式与至少一种长链脂肪胺反应制备的可溶性中间体；（2）通过将下面给出的式I所披露的一个或多个化合物与至少一种长链脂肪胺反应以形成式I化合物的脂肪胺盐来溶解一个或多个化合物的过程；以及（3）包括至少一种可溶性中间体，即式I化合物的脂肪胺盐的成品杀虫剂产品。其中R1是环丙基，可选地取代为1-5个R5，异丙基，可选地取代为1-5个R6，或苯基，可选地取代为1-3个R7；R2是((O)jC(R15)(R16))kR；R是CO2H或CO2H的除草剂有效衍生物；R3是卤素，氰基，硝基，OR20，SR21或N(R22)R23；R4是—N(R24)R25或—NO2；j为0或1；k为0或1；但当k为0时，j为0；而R5、R6、R7、R15、R16、R20、R21、R22、R23、R24和R25如披露中所定义。

  公开号：

  US20130303369A1

文献信息

• [EN] HERBICIDAL PROPYNYL-PHENYL COMPOUNDS<br/>[FR] COMPOSÉS PROPYNYLE-PHÉNYLE HERBICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2015197468A1

  公开（公告）日：2015-12-30

  The present invention relates to a compound of formula (I) wherein: R1 is C1-C3alkoxy, C1-C2alkoxy-C1-C3alkoxy, C1-C2fluoroalkoxy, ethyl, n-propyl, n-butyl, cyclopropyl or ethynyl; R2 is hydrogen, ethyl, n-propyl, cyclopropyl, vinyl, ethynyl, C1-C3alkoxy, C1-C3fluoroalkyl, C1-C2fluoroalkoxy, C1-C2alkoxy-C1-C3alkoxy-, or C1fluoroalkoxy-C1-C3alkoxy-; provided that when R1 is ethyl, n-propyl, n-butyl, cyclopropyl or ethynyl, then R2 is hydrogen, ethyl, n-propyl, cyclopropyl, vinyl or ethynyl; and Y is O, S, S(O), S(O)2, N(C1-C2alkyl), N(C1-C2alkoxy), C(O), CR8R9 or -CR10R11CR12R13-; and and G, R3, R4, R5 and R6 are as defined herein; wherein the compound of formula (I) is optionally present as an agrochemically acceptable salt thereof. These compounds are suitable for use as herbicides. The invention therefore also relates to a method of controlling weeds, especially grassy monocotyledonous weeds, in crops of useful plants, comprising applying a compound of formula (I), or a herbicidal composition comprising such a compound, to the plants or to the locus thereof.

  本发明涉及一种具有以下结构的化合物（I）：其中：R1为C1-C3烷氧基，C1-C2烷氧基-C1-C3烷氧基，C1-C2氟烷氧基，乙基，正丙基，正丁基，环丙基或乙炔基；R2为氢，乙基，正丙基，环丙基，乙烯基，乙炔基，C1-C3烷氧基，C1-C3氟烷基，C1-C2氟烷氧基，C1-C2烷氧基-C1-C3烷氧基，或C1氟烷氧基-C1-C3烷氧基-；但是当R1为乙基，正丙基，正丁基，环丙基或乙炔基时，R2为氢，乙基，正丙基，环丙基，乙烯基或乙炔基；Y为O，S，S(O)，S(O)2，N(C1-C2烷基)，N(C1-C2烷氧基)，C(O)，CR8R9或-CR10R11CR12R13-；以及G，R3，R4，R5和R6如本文所定义；其中化合物（I）可作为农药中可接受的盐存在。这些化合物适用于用作除草剂。因此，本发明还涉及一种控制杂草，特别是草本单子叶杂草，在有用植物作物中的方法，包括将化合物（I）或含有这种化合物的除草剂组合物施用于植物或其生长地点。
• [EN] HERBICIDALLY ACTIVE 2-(SUBSTITUTED-PHENYL)-CYCLOPENTANE-1,3-DIONE COMPOUNDS AND DERIVATIVES THEREOF<br/>[FR] COMPOSÉS DE 2-(PHÉNYL SUBSTITUÉ)-CYCLOPENTANE-1,3-DIONE PRÉSENTANT UNE ACTIVITÉ HERBICIDE, ET LEURS DÉRIVÉS
  申请人：SYNGENTA LTD

  公开号：WO2014170413A1

  公开（公告）日：2014-10-23

  The present invention relates to a compound of formula (I): wherein the substituents are as defined herein, and wherein the compound of formula (I) is optionally present as an agrochemically acceptable salt thereof. These compounds are thought to be suitable for use as herbicides. The invention therefore also relates to a method of controlling weeds, especially grassy monocotyledonous weeds, in crops of useful plants, comprising applying a compound of formula (I), or a herbicidal composition comprising such a compound, to the plants or to the locus thereof.

  本发明涉及一种化合物，其化学式为（I）：其中取代基如本文所定义，并且化合物（I）可以选择地以其农药可接受的盐的形式存在。这些化合物被认为适合用作除草剂。因此，本发明还涉及一种控制杂草的方法，特别是在有用植物的作物中控制禾本科杂草，包括将化合物（I）或包含这种化合物的除草剂组合物施用于植物或其生长地点。
• [EN] 2-(SUBSTITUTED-PHENYL)-CYCLOPENTANE-1,3-DIONE COMPOUNDS, AND DERIVATIVES THEREOF<br/>[FR] COMPOSÉS DE 2-(PHÉNYL SUBSTITUÉ)-CYCLOPENTANE-1,3-DIONES ET LEURS DÉRIVÉS
  申请人：SYNGENTA LTD

  公开号：WO2013079708A1

  公开（公告）日：2013-06-06

  The present invention relates to a compound of formula (I): wherein: X is methyl or chlorine; R1 is methyl or chlorine; R2 is hydrogen, methyl, ethyl, n-propyl, cyclopropyl, vinyl, ethynyl, fluorine, chlorine, bromine, methoxy, ethoxy or fluoromethoxy; and G, R3, R4, R5 and R6 are as defined herein; wherein the compound of formula (I) is optionally present as an agrochemically acceptable salt thereof. These compounds are suitable for use as herbicides. The invention therefore also relates to a method of controlling weeds, especially grassy monocotyledonous weeds, in crops of useful plants, comprising applying a compound of formula (I), or a herbicidal composition comprising such a compound, to the plants or to the locus thereof.

  本发明涉及一种具有以下式（I）的化合物：其中：X为甲基或氯；R1为甲基或氯；R2为氢、甲基、乙基、正丙基、环丙基、乙烯基、乙炔基、氟、氯、溴、甲氧基、乙氧基或氟甲氧基；以及G、R3、R4、R5和R6如本文所定义；其中式（I）的化合物可以作为农药中可接受的盐存在。这些化合物适用于用作除草剂。因此，本发明还涉及一种控制杂草，特别是草本单子叶杂草，在有用植物作物中的方法，包括将式（I）的化合物或包含这种化合物的除草剂组合物施用于植物或其生长地点。
• 2-(SUBSTITUTED-PHENYL)-CYCLOPENTANE-1,3-DIONE COMPOUNDS, AND DERIVATIVES THEREOF
  申请人：Syngenta Limited

  公开号：US20140323303A1

  公开（公告）日：2014-10-30

  The present invention relates to a compound of formula (I): wherein: X is methyl or chlorine; R 1 is methyl or chlorine; R 2 is hydrogen, methyl, ethyl, n-propyl, cyclopropyl, vinyl, ethynyl, fluorine, chlorine, bromine, methoxy, ethoxy or fluoromethoxy; and G, R 3 , R 4 , R 5 and R 6 are as defined herein; wherein the compound of formula (I) is optionally present as an agrochemically acceptable salt thereof. These compounds are suitable for use as herbicides. The invention therefore also relates to a method of controlling weeds, especially grassy monocotyledonous weeds, in crops of useful plants, comprising applying a compound of formula (I), or a herbicidal composition comprising such a compound, to the plants or to the locus thereof.

  本发明涉及一种具有以下式（I）的化合物：其中：X为甲基或氯；R1为甲基或氯；R2为氢、甲基、乙基、正丙基、环丙基、乙烯基、乙炔基、氟、氯、溴、甲氧基、乙氧基或氟甲氧基；以及G、R3、R4、R5和R6如本文所定义；其中该式（I）的化合物可以作为农药可接受的盐存在。这些化合物适用于用作除草剂。因此，本发明还涉及一种控制杂草，特别是草本单子叶杂草，在有用植物作物中的方法，包括将式（I）的化合物或包含这种化合物的除草剂组合物施用于植物或其生长地点。
• [EN] SUBSTITUTED PYRIMIDINES AND TRIAZINES AS HERBICIDES<br/>[FR] PYRIMIDINES ET TRIAZINES SUBSTITUÉES UTILISÉES EN TANT QU'HERBICIDES
  申请人：FMC CORP

  公开号：WO2021183980A1

  公开（公告）日：2021-09-16

  Disclosed are compounds of Formula I, stereoisomers, TV-oxides, and salts thereof, wherein; A is selected from A-2, A-2, A-3, A-4, A-5, A-6, A-7, A-8, A-9 and A-10 and A, A-l, A-2, A-3, A-4, A-5, A-6, A-7, A-8, A-9, A-10, R1 through R20b, W, X and Y are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula I and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention.

  公开的是Formula I的化合物，立体异构体，TV-氧化物及其盐，其中；A从A-2，A-2，A-3，A-4，A-5，A-6，A-7，A-8，A-9和A-10中选择，A，A-l，A-2，A-3，A-4，A-5，A-6，A-7，A-8，A-9，A-10，R1到R20b，W，X和Y如披露中定义。还公开了含有Formula I化合物的组合物以及用于控制不受欢迎植被的方法，包括将不受欢迎的植被或其环境与本发明的化合物或组合物的有效量接触。