环丙喹宗 | 33453-23-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 环丙喹宗
• 中文别名: 萨普罗喹酮
• 英文名称: 1-Cyclopropylmethyl-4-phenyl-6-methoxy-2(1H)-chinazolinon
• 英文别名: 1-(Cyclopropyl-methyl)-4-phenyl-6-methoxy-1H-chinazolinon-(2)；1-Cyclopropylmethyl-4-phenyl-6-methoxy-2(1H)-quinazolinone；1-cyclopropylmethyl-6-methoxy-4-phenyl-1H-quinazolin-2-one；ciproquazone；1-(cyclopropylmethyl)-6-methoxy-4-phenylquinazolin-2-one
• CAS: 33453-23-5
• 化学式: C₁₉H₁₈N₂O₂
• 分子量: 306.364
• InChiKey: VAFNJIFAZJWWNI-UHFFFAOYSA-N

物化性质

• 熔点：
  115-116 °C(Solv: ethyl acetate (141-78-6))
• 沸点：
  483.8±47.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  41.9
• 氢给体数：
  0
• 氢受体数：
  2

制备方法与用途

Ciproquazone 具有镇痛作用，可用于治疗脊柱炎。

反应信息

• 作为产物：
  描述：

  1-cyclopropylmethyl-6-methoxy-4-phenyl-3,4-dihydro-1H-quinazolin-2-one 生成 环丙喹宗
  参考文献：
  名称：

  YAMAMOTO, MICHIHIRO;KATAYAMA, SHIGENARI;KOSHIBA, MASAO;YAMAMOTO, HISAO

  摘要：

  DOI：

文献信息

• Novel pharmaceutical compounds
  申请人：Grimm Erich L.

  公开号：US20080188521A1

  公开（公告）日：2008-08-07

  The instant invention provides compounds of Formula I which are leukotriene biosynthesis inhibitors. Compounds of Formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.

  这种瞬间发明提供了化合物I的公式，这些化合物是白三烯生物合成抑制剂。 公式I的化合物可用作抗动脉粥样硬化、抗哮喘、抗过敏、抗炎和细胞保护剂。
• [EN] 7- (1, 3-THIAZOL-2-YL)THIO!-COUMARIN DERIVATIVES AND THEIR USE AS LEUKOTRIENE BIOSYNTHESIS INHIBITORS<br/>[FR] DERIVES DE 7- (1,3-THIAZOL-2-YL)THIO !COUMARINE ET UTILISATION DE CEUX-CI EN TANT QU'INHIBITEURS DE LA BIOSYNTHESE DES LEUCOTRIENES
  申请人：MERCK FROSST CANADA INC

  公开号：WO2004108720A1

  公开（公告）日：2004-12-16

  The instant invention provides compounds of Formula (I) which are leukotriene biosynthesis inhibitors. Compounds of formula (I) are useful as anti-asthmatic, anti-allergic, anti-inflammatory, cytoprotective and anti-artherosclerotic agents.

  这种瞬时发明提供了化合物的公式(I)，这些化合物是白三烯生物合成抑制剂。公式(I)的化合物可用作抗哮喘、抗过敏、抗炎、细胞保护和抗动脉粥样硬化药物。
• [EN] 5-OXO-ETE RECEPTOR ANTAGONIST COMPOUNDS<br/>[FR] COMPOSÉS ANTAGONISTES DES RÉCEPTEURS 5-OXO-ETE
  申请人：UNIV MCGILL

  公开号：WO2010127452A1

  公开（公告）日：2010-11-11

  The present invention relates to novel pharmaceutically-useful compounds which are antagonists of the 5-oxo-ETE receptors, such as the OXE receptor. These compounds have use as therapeutic and/or prophylactic agents for diseases characterized by tissue eosinophilia, such as inflammatory conditions including respiratory diseases. The invention also relates to pharmaceutical compositions, to the use of such compounds and compositions as medicaments, and to therapeutic methods.

  本发明涉及一种新型的药用化合物，它们是5-oxo-ETE受体的拮抗剂，如OXE受体。这些化合物可用作治疗和/或预防组织嗜麻细胞增多等疾病的药物，如包括呼吸道疾病在内的炎症性疾病。该发明还涉及制药组合物，以及将这些化合物和组合物用作药物、以及治疗方法。
• Process for preparing 2(1H)-quinazolinone derivatives
  申请人：Sumitomo Chemical Company, Limited

  公开号：US04387223A1

  公开（公告）日：1983-06-07

  2(1H)-Quinazolinone and quinazolinethione derivatives having excellent pharmacological activities are produced in high yield with high purity by heating the corresponding 3,4-dihydro-2(1H)-quinazolinone or quinazolinethione derivatives together with sulfur in an inert solvent.

  通过在惰性溶剂中加热相应的3,4-二氢-2(1H)-喹唑啉酮或喹唑啉硫醚衍生物与硫一起，可以高产高纯度地生产具有优异药理活性的2(1H)-喹唑啉酮和喹唑啉硫醚衍生物。
• [EN] TRIAZOLOPYRIDINE COMPOUNDS USEFUL AS PESTICIDES<br/>[FR] COMPOSÉS TRIAZOLOPYRIDINE UTILES EN TANT QUE PESTICIDES
  申请人：OAT & IIL INDIA LABORATORIES PRIVATE LTD

  公开号：WO2022003510A1

  公开（公告）日：2022-01-06

  The present disclosure provides a novel triazolopyridine compound as represented by formula (I) or a salt thereof that controls pests: wherein, R1 and R3 independently represent hydrogen, or the like; R2 represents C1-C6 alkyl, C3-C8 cycloalkyl, C1-C6 alkoxy, or the like; R4, R5, R7, and R8 independently represent hydrogen, halogen, or the like; R6 represents C1-C6 haloalkoxy, or the like; and Z represents an oxygen atom, a sulfur atom, SO, or SO2.

  本公开提供一种新型三唑吡啶化合物，其由式（I）或其盐表示，用于控制害虫：其中，R1和R3独立地表示氢或类似物；R2表示C1-C6烷基，C3-C8环烷基，C1-C6烷氧基或类似物；R4、R5、R7和R8独立地表示氢，卤素或类似物；R6表示C1-C6卤代烷氧基或类似物；Z表示氧原子，硫原子，SO或SO2。