2-(4-methylphenyl)-5-methyl-4-hydroxymethyl-1H-imidazole | 62229-99-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-methylphenyl)-5-methyl-4-hydroxymethyl-1H-imidazole
• 英文别名: [5-Methyl-2-(4-methylphenyl)-1H-imidazol-4-yl]methanol
• CAS: 62229-99-6
• 化学式: C₁₂H₁₄N₂O
• 分子量: 202.256
• InChiKey: WWXRDEDHUNFFFG-UHFFFAOYSA-N

物化性质

• 沸点：
  447.3±33.0 °C(Predicted)
• 密度：
  1.171±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  48.9
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(4-methylphenyl)-5-methyl-4-hydroxymethyl-1H-imidazole 、 二苯甲基哌嗪 、 sodium hydroxide 、 溴化锂 以 乙醇 、 水 为溶剂， 反应 21.0h， 以to produce the 383.6 g of the title compound (0.88 mole, 88% yield)的产率得到利法利嗪
  参考文献：
  名称：

  Cationic effect-driven carbinol/amine reaction

  摘要：

  芳基和杂环甲胺可以通过在阳离子效应试剂存在下将羟基芳基甲醇或杂环甲醇与一级或二级胺反应制备。

  公开号：

  US05142052A1
• 作为产物：
  描述：

  醋酸异丙酯 、 对甲苯腈 、 2,3-丁二酮 以 盐酸 、 NH₃ -saturated methanol 、 乙醇 、 水 为溶剂， 生成 2-(4-methylphenyl)-5-methyl-4-hydroxymethyl-1H-imidazole
  参考文献：
  名称：

  Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives

  摘要：

  Formula A的咪唑基-烷基-哌嗪和二氮杂环衍生物：##STR1##其中：R.sup.1为芳基，较低烷基，环烷基或氢；R.sup.2为芳基，较低烷基或氢；R.sup.3为较低烷基，羟基或氢；R.sup.4为芳基或氢；R.sup.5为芳基或氢；m为二或三；n为零，一或二，但当R.sup.3为羟基时，n为一或二；q为零，一，二或三；及其药学上可接受的盐，用于治疗患有各种疾病状态的哺乳动物，包括：通过直接神经保护治疗的疾病，如缺血，包括局部和全局缺血，脊髓损伤，头部创伤以及阿尔茨海默病和亨廷顿舞蹈症等神经系统疾病；通过抑制钠离子治疗的疾病，如尿毒症和低钠性脑病；以及通过钙通道拮抗剂治疗的疾病，包括：通过抑制脑血管痉挛和脑血管扩张治疗的疾病，如偏头痛，中风，由蛛网膜下腔出血引起的血管痉挛，癫痫或癫痫性精神症状，以及可卡因滥用引起的脑血管缺血；以及心血管疾病，如高血压，心绞痛，稳定和不稳定性心绞痛，普林兹梅塔心绞痛，心律失常，血栓形成，栓塞，以及慢性或急性心力衰竭，以及由于外周血管疾病引起的下肢缺血，例如间歇性跛行；平滑肌痉挛：如输尿管，膀胱，子宫痉挛，利尿和肠易激综合征；以及手术期间的用途：如旁路移植，血管造影，血管成形术，器官移植期间的器官保护，高血压危机或术后高血压。

  公开号：

  US05043447A1

文献信息

• HEAT-CURABLE RESIN COMPOSITION, PREPREG, AND METHOD FOR PRODUCING FIBER-REINFORCED COMPOSITE USING EACH OF SAME
  申请人：Toho Tenax Co., Ltd.

  公开号：EP3075785A1

  公开（公告）日：2016-10-05

  The present invention provides a heat-curable resin composition, which comprises (1) a heat-curable resin mixture comprising a heat-curable resin (a) and thickener particles (b) and exhibiting a viscosity (150°C) after having been held at a temperature of 150°C for 30 seconds that is a viscosity (S), and (2) a curing agent, and is characterized in that the heat-curable resin composition exhibits a lowest viscosity (R) at 80-120°C, the lowest viscosity (R) is 0.1-10 Pa·s, and the viscosity (S) and lowest viscosity (R) satisfy the relationship of formula (1): 5 < S/R < 200 ...formula (1).

  本发明提供了一种热固化树脂组合物，它包括(1)热固化树脂混合物，该混合物由热固化树脂(a)和增稠剂颗粒(b)组成，在150℃的温度下保持30秒后表现出粘度(S)，(2)固化剂，其特征在于热固化树脂组合物在80-120℃时表现出最低粘度(R)，最低粘度(R)为0.1-10 Pa-s，粘度 (S) 和最低粘度 (R) 满足式 (1) 的关系：5 < S/R < 200 ......式（1）。
• EPOXY RESIN COMPOSITION, PREPREG, CARBON FIBER-REINFORCED COMPOSITE MATERIAL, AND MANUFACTURING METHODS THEREFOR
  申请人：Toho Tenax Co., Ltd.

  公开号：EP3279263A1

  公开（公告）日：2018-02-07

  The present invention provides an epoxy resin composition comprising at least the following component [A], component [B] and component [C], the epoxy resin composition being characterized in that: the mixture of component [A] and component [B] is a mixture that, when temperature is increased at 2°C/min, begins to thicken at temperature (T1) and completes thickening at temperature (T2), temperature (T1) being 80-110°C and temperature (T1) and temperature (T2) satisfying the relationship of expression (1) 5°C ≤ (T2-T1) ≤ 20°C expression (1); and the mixture of component [A] and component [C] is a mixture that, when temperature is increased at 2°C/min, begins to cure at temperature (T3), temperature (T1) and temperature (T3) satisfying the relationship of expression (2) 5°C ≤ (T3-T1) ≤ 80°C expression (2). Component [A]: epoxy resin Component [B]: thickening particle Component [C]: curing agent

  本发明提供了一种环氧树脂组合物，至少包括下列组分[A]、组分[B]和组分[C]，该环氧树脂组合物的特征在于：组分[A]和组分[B]的混合物，当温度以2℃/分钟的速度升高时，在温度(T1)时开始增稠，在温度(T2)时完成增稠，温度(T1)为80-110℃，温度(T1)和温度(T2)满足表达式(1)5℃≤(T2-T1)≤20℃表达式(1)的关系；组分[A]和组分[C]的混合物，当温度以 2℃/分钟的速度升高时，开始固化的温度（T3）、温度（T1）和温度（T3）满足表达式（2）的关系 5℃≤（T3-T1）≤80℃ 表达式（2）。 组分 [A]：环氧树脂 组分 [B]：增稠粒子 组分 [C]：固化剂
• SELF-ADHESIVE PREPREG AND METHOD FOR PRODUCING SAME
  申请人：Teijin Limited

  公开号：EP3603915A1

  公开（公告）日：2020-02-05

  The present invention provides a self-adhesive prepreg which is characterized by comprising: a base prepreg that is composed of reinforcing fibers and a thermosetting resin composition (I), some or all of which is impregnated into a reinforcing fiber layer that is formed of the reinforcing fibers; an adhesive layer that is composed of a nonwoven fabric which is laminated on at least one surface of the base prepreg so as to be integrated with the base prepreg and a thermosetting resin composition (II) which is laminated on the surface of the nonwoven fabric so as to be integrated with the nonwoven fabric.

  本发明提供了一种自粘预浸料，其特征在于包括基体预浸料，由增强纤维和热固性树脂组合物 (I) 组成，其中部分或全部浸渍在由增强纤维形成的增强纤维层中； 粘合层，由无纺布和热固性树脂组合物 (II) 组成，无纺布层压在基体预浸料的至少一个表面上，以便与基体预浸料融为一体，热固性树脂组合物 (II) 层压在无纺布的表面上，以便与无纺布融为一体。
• MOLDING MATERIAL AND FIBER-REINFORCED COMPOSITE MATERIAL
  申请人：Mitsubishi Chemical Corporation

  公开号：EP3632982A1

  公开（公告）日：2020-04-08

  A molding material that enables acquirement of a fiber-reinforced composite material which has excellent demoldability from a mold and excellent surface appearance, which contaminates a mold surface after molding less, and which has excellent mechanical properties and heat resistance; and a fiber-reinforced composite material which has excellent demoldability from a mold and surface appearance, which contaminates a mold surface after molding less, and which has excellent mechanical properties and heat resistance, are provided. A molding material of the present invention includes a component (A): an epoxy resin; a component (B): an epoxy resin curing agent; a component (C): a compound that has a solubility parameter of 11.2 or less and a melting point of 115°C or lower; and a reinforcement fiber.

  本发明提供了一种成型材料，该材料可获得从模具脱模性和表面外观优异、成型后对模具表面污染少、机械性能和耐热性优异的纤维增强复合材料；以及一种从模具脱模性和表面外观优异、成型后对模具表面污染少、机械性能和耐热性优异的纤维增强复合材料。本发明的一种成型材料包括组分（A）：环氧树脂；组分（B）：环氧树脂固化剂；组分（C）：溶解度参数为 11.2 或以下、熔点为 115°C 或以下的化合物；以及增强纤维。
• CARBON FIBER BUNDLE, PREPREG, AND FIBER-REINFORCED COMPOSITE MATERIAL
  申请人：Teijin Limited

  公开号：EP3719184A1

  公开（公告）日：2020-10-07

  The objective of the present invention is to provide a carbon fiber having an excellent strength development ratio when used in a composite material. The present invention, which resolves this problem, simultaneously satisfies expressions (1) and (2). Lc/d≤3 TS×d×Lc>6.0×105 Lc: X-ray crystallite size (Å) d: single fiber diameter (µm) TS: Strand tensile strength (MPa)

  本发明的目的是提供一种在复合材料中使用时具有优异强度发展比的碳纤维。本发明解决了这一问题，同时满足表达式（1）和（2）。Lc/d≤3 TS×d×Lc>6.0×105 Lc：X 射线晶粒尺寸（埃） d：单纤维直径（微米） TS：股拉伸强度（兆帕）