The present invention relates to compounds, pharmaceutical compositions and formulations that have a structure (I). The compounds comprise a heterocyclic ring where W, X, Y, and Z generally and independently are S, N or C with the proviso that at least 2 of these positions in the ring are other than carbon. A pyridine or a substituted pyridine A ring and a phenyl or a substituted phenyl B ring are covalently bonded to the heterocyclic ring. Further provided are methods for treating a metabolic disorder, cell proliferative disease, reducing body weight or increasing thermogenesis during weight loss with the compounds of structure as described or pharmaceutically acceptable salt or stereoisomer thereof or both.
本发明涉及具有结构(I)的化合物、药物组合物和制剂。这些化合物包括一个杂环,其中 W、X、Y 和 Z 一般独立地为 S、N 或 C,但环中至少有 2 个位置是碳以外的位置。
吡啶或取代
吡啶 A 环和苯基或取代苯基 B 环以共价键连接到杂环上。进一步提供了用所述结构的化合物或其药学上可接受的盐或立体异构体或两者治疗代谢紊乱、细胞增殖性疾病、减轻体重或在减肥过程中增加产热的方法。