2,4-bis(2,4-dimethylphenoxymethyl)(3,3-diethyltriaz-1-en-1-yl)benzene | 1253261-40-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2,4-bis(2,4-dimethylphenoxymethyl)(3,3-diethyltriaz-1-en-1-yl)benzene
• 英文别名: N-[[2,4-bis[(2,4-dimethylphenoxy)methyl]phenyl]diazenyl]-N-ethylethanamine
• CAS: 1253261-40-3
• 化学式: C₂₈H₃₅N₃O₂
• 分子量: 445.605
• InChiKey: XEWVMRPKHIPRCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  46.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,4-bis(2,4-dimethylphenoxymethyl)(3,3-diethyltriaz-1-en-1-yl)benzene 在 碘甲烷 作用下， 反应 24.0h， 以89%的产率得到2,4-bis(2,4-dimethylphenoxymethyl)iodobenzene
  参考文献：
  名称：

  Convergent Synthesis of Geometrically Disassembling Dendrimers using Cu(I)-Catalyzed C−O Bond Formation

  摘要：

  The convergent synthesis of geometrically degradable dendrimers based on the 2,4-bis(hydroxymethyl)phenol subunit is presented. The key step of the synthetic scheme involves the CuI/3,4,7,8-tetramethyl-1,10-phenanthroline-catalyzed coupling of aryl iodides and alcohols. The synthesis and disassembly of these compounds is discussed.

  DOI：

  10.1021/ol102081q
• 作为产物：
  描述：

  2,4-二甲基-1-碘苯 、 2,4-bishydroxymethyl(3,3-diethyltriaz-1-en-1-yl)benzene 在 copper(l) iodide 、 3,4,7,8-四甲基-1,10-菲罗啉 、 caesium carbonate 作用下， 以 甲苯 为溶剂， 反应 72.0h， 以74%的产率得到2,4-bis(2,4-dimethylphenoxymethyl)(3,3-diethyltriaz-1-en-1-yl)benzene
  参考文献：
  名称：

  Convergent Synthesis of Geometrically Disassembling Dendrimers using Cu(I)-Catalyzed C−O Bond Formation

  摘要：

  The convergent synthesis of geometrically degradable dendrimers based on the 2,4-bis(hydroxymethyl)phenol subunit is presented. The key step of the synthetic scheme involves the CuI/3,4,7,8-tetramethyl-1,10-phenanthroline-catalyzed coupling of aryl iodides and alcohols. The synthesis and disassembly of these compounds is discussed.

  DOI：

  10.1021/ol102081q

文献信息

• Convergent Synthesis of Geometrically Disassembling Dendrimers using Cu(I)-Catalyzed C−O Bond Formation
  作者：Nathan W. Polaske、Michael L. Szalai、Charles S. Shanahan、Dominic V. McGrath

  DOI：10.1021/ol102081q

  日期：2010.11.5

  The convergent synthesis of geometrically degradable dendrimers based on the 2,4-bis(hydroxymethyl)phenol subunit is presented. The key step of the synthetic scheme involves the CuI/3,4,7,8-tetramethyl-1,10-phenanthroline-catalyzed coupling of aryl iodides and alcohols. The synthesis and disassembly of these compounds is discussed.