N,N-bis(carboxymethyl)glycine methyl ester | 38841-92-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N-bis(carboxymethyl)glycine methyl ester
• 英文别名: methyl glycine diacetic acid；N,N-Bis(carboxymethyl)glycine 1-methyl ester；2-[carboxymethyl-(2-methoxy-2-oxoethyl)amino]acetic acid
• CAS: 38841-92-8
• 化学式: C₇H₁₁NO₆
• 分子量: 205.167
• InChiKey: YQOCHIIDVCLPOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-(4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)phenoxy)-N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)acetamide dihydrochloride 、 N,N-bis(carboxymethyl)glycine methyl ester 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.5h， 以75%的产率得到17-(4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)phenoxy)-3-(2-methoxy-2-oxoethyl)-5,16-dioxo-9,12-dioxa-3,6,15-triazaheptadecanoic acid
  参考文献：
  名称：

  Heterobivalent Ligand for the Adenosine A_2A–Dopamine D₂ Receptor Heteromer

  摘要：

  DOI：

  10.1021/acs.jmedchem.1c01763
• 作为产物：
  描述：

  N,N-bis(benzyloxycarbonylmethyl)glycine methyl ester 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 反应 3.0h， 以99%的产率得到N,N-bis(carboxymethyl)glycine methyl ester
  参考文献：
  名称：

  与 G 蛋白偶联受体同源二聚体具有皮摩尔结合亲和力的真正二价配体的设计

  摘要：

  二价配体已成为研究 G 蛋白偶联受体二聚体的化学工具。使用计算、化学和生化工具的组合，我们在此描述了对多巴胺 D 2受体 (D 2 R) 同型二聚体具有高亲和力 ( K DB1 = 21 pM)的二价配体13的设计。二价配体13相对于单价化合物15的结合亲和力提高了37 倍，表明两种原体同时结合。使用具有 D 2跨膜 (TM) 结构域氨基酸序列的合成肽R，我们提供证据证明 TM6 形成同源二聚体的界面。值得注意的是，干扰肽 TAT-TM6 将二价配体13的结合降低了52 倍，并且对单价化合物15没有影响，证实了 D 2 R 同源二聚体通过 TM6 离体。总之，通过使用多功能多价化学平台，我们开发了一种精确的策略来生成真正的二价配体，该配体同时靶向 D 2 R 同型二聚体的两个正构位点。

  DOI：

  10.1021/acs.jmedchem.8b01249

文献信息

• Photoelectric response of ITO electrode sensitized by single-layer C60-aminodicarboxylate derivative C60(C7H13NO4)
  作者：Wen Zhang、Liangbing Gan、Chunhui Huang

  DOI：10.1039/a800359i

  日期：——

  A single layer of an amphiphilic C60-aminodicarboxylate (C60AC) derivative has been fabricated on semiconducting transparent ITO electrodes with transfer ratios of about 0.900.05 at 25mNm1 by the Langmuir-Blodgett (LB) technique. The photoelectric response of the modified electrodes has been investigated under a nitrogen atmosphere. The photocurrent action spectrum shows that the excited C60AC acts as a photoactive species in the photoinduced electron transfer process. Factors such as the intensity of the irradiation, concentration of reducing agent in the electrolyte solution and bias voltage have been studied. The results indicate that electrons flow from the electrolyte through LB film to the ITO electrode. The quantum yield is 3.0 under favorable conditions.-6

  通过 Langmuir-Blodgett (LB) 技术，在半导体透明 ITO 电极上制备了单层两亲性 C60-氨基二羧酸酯 (C60AC) 衍生物，在 25mNm1 下传输比约为 0.900.05。在氮气气氛下研究了修饰电极的光电响应。光电流作用光谱表明，激发的C60AC在光致电子转移过程中充当光活性物质。研究了辐照强度、电解质溶液中还原剂浓度和偏压等因素。结果表明，电子从电解质通过LB膜流向ITO电极。有利条件下量子产率为3.0-6
• [EN] PROCESS TO PREPARE A SOLID COMPOSITION OF AN AMINO ACID DIACETIC ACID<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UNE COMPOSITION SOLIDE D'ACIDE AMINÉ DIACÉTIQUE
  申请人：AKZO NOBEL CHEMICALS INT BV

  公开号：WO2019007943A1

  公开（公告）日：2019-01-10

  The present invention relates to a process for the preparation of a solid composition of an amino acid diacetic acid compound wherein the amino acid diacetic acid compound is methyl glycine-N,N-diacetic acid or a salt thereof, or glutamic N,N-diacetic acid or a derivative thereof, containing a step of feeding a saturated or oversaturated aqueous composition of the amino acid diacetic acid compound in an aqueous solvent to a drum dryer,wherein the aqueous composition is fed to the drum surface with a layer thickness of 0.1-10 mm, the drum has a surface temperature of 80-180°C, and the drum operates at a tangential speed of 0.1 -100 m/min and the mass is removed from the drum before a full revolution of the drum, and the product obtainable by the process.

  本发明涉及一种制备氨基酸二乙酸化合物固体组合物的方法，其中氨基酸二乙酸化合物是甲基甘氨酸-N，N-二乙酸或其盐，或谷氨酸N，N-二乙酸或其衍生物，包括向滚筒干燥器中供给饱和或过饱和的氨基酸二乙酸化合物水溶液的步骤，其中将水溶液以0.1-10毫米的层厚度喂到滚筒表面，滚筒表面温度为80-180°C，滚筒以0.1-100米/分钟的切向速度运转，质量在滚筒完整旋转之前从滚筒上移除，以及通过该方法获得的产品。
• Diamine and Iminodiacetic Acid Hydroxamic Acid Derivatives
  申请人：Miller Thomas A.

  公开号：US20090023718A1

  公开（公告）日：2009-01-22

  The present invention relates to a novel class of hydroxamic acid derivatives having a diamine or iminodiacetic acid backbone. The hydroxamic acid compounds can be used to treat cancer. The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively including terminal differentiation, arresting cell growth and/or apoptosis of neo-plastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compound of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives, and safe, dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.

  本发明涉及一种新型的羟肟酸衍生物类，其具有二胺或亚胺二乙酸骨架。这些羟肟酸化合物可用于治疗癌症。这些羟肟酸化合物还可以抑制组蛋白去乙酰化酶，并适用于选择性地促进新生物细胞的终端分化，阻止细胞生长和/或细胞凋亡，从而抑制这些细胞的增殖。因此，本发明的化合物在治疗具有新生物细胞增殖特征的肿瘤患者中非常有用。该发明的化合物还可用于预防和治疗TRX介导的疾病，例如自身免疫、过敏和炎症性疾病，以及中枢神经系统（CNS）疾病的预防和/或治疗，例如神经退行性疾病。本发明还提供了包含羟肟酸衍生物的药物组合物，以及这些药物组合物的安全、剂量方案，易于遵循，并在体内产生治疗有效量的羟肟酸衍生物。
• Detergent compositions containing components modified to float in water
  申请人：UNILEVER N.V.

  公开号：EP1344815A1

  公开（公告）日：2003-09-17

  Modified bleaching agents and enzymes for detergent compositions are described. The modified bleaching agents and enzymes have a wax clad and detergent compositions having the modified bleaching agents and enzymes display superior cleaning benefits.

  描述了用于洗涤剂组合物的改性漂白剂和酶。改性漂白剂和酶具有蜡质包覆层，具有改性漂白剂和酶的洗涤剂组合物显示出卓越的清洁效果。
• Liquid hand dishwashing detergent composition
  申请人：The Procter and Gamble Company

  公开号：EP2264136A1

  公开（公告）日：2010-12-22

  A hand dishwashing detergent composition comprising a chelant and branched surfactants to provide superior grease cleaning and shine.

  一种由螯合剂和支链表面活性剂组成的手洗餐具洗涤剂组合物，可提供卓越的油脂清洁效果和光泽。