methyl 6'-azido-3'-(2,2-dimethyl-4,13-dioxo-3-oxa-5,12,15-triazaheptadecan-17-ylcarbamoyl)biphenyl-2-carboxylate | 1396893-85-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 6'-azido-3'-(2,2-dimethyl-4,13-dioxo-3-oxa-5,12,15-triazaheptadecan-17-ylcarbamoyl)biphenyl-2-carboxylate
• 英文别名: Methyl 2-[2-azido-5-[2-[[2-[6-[(2-methylpropan-2-yl)oxycarbonylamino]hexylamino]-2-oxoethyl]amino]ethylcarbamoyl]phenyl]benzoate
• CAS: 1396893-85-8
• 化学式: C₃₀H₄₁N₇O₆
• 分子量: 595.699
• InChiKey: OQDWORBOAPRBEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  43
• 可旋转键数：
  19
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  149
• 氢给体数：
  4
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  methyl 6'-azido-3'-(2,2-dimethyl-4,13-dioxo-3-oxa-5,12,15-triazaheptadecan-17-ylcarbamoyl)biphenyl-2-carboxylate 在 4-二甲氨基吡啶 、 碳酸氢钠 、 三乙胺 、 三氟乙酸 作用下， 以 水 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 25.0h， 生成 12-(2-(6-azido-2'-(methoxycarbonyl)-[1,1'-biphenyl]-3-carboxamido)ethyl)-24-bromo-3,6,9-tris(carboxymethyl)-11,14,23-trioxo-3,6,9,12,15,22-hexaazatetracosanoic acid
  参考文献：
  名称：

  Long-Lived Luminogenic Probe for Detection of RNA in a Crude Solution of Living Bacterial Cells

  摘要：

  A pre-type sensitizer for a lanthanide complex on an oligonucleotide was successfully converted to a perfect final structure in a target DNA/RNA-templated reaction, without any chemical reagent or enzyme, under neutral conditions. The final form of the lanthanide oligonucleotide provided a long-lived luminescence signal, appropriate for time-gated luminescence analysis and signal amplification. Target DNA/RNA-assisted time-gated luminescence analysis is a powerful tool for elimination of autofluorescence and detection of target RNA in living bacterial cells.

  DOI：

  10.1021/ja406724k
• 作为产物：
  描述：

  methyl 4-(3,3-diethyltriaz-1-enyl)-3-iodobenzoate 在 N-甲基吗啉 、 potassium phosphate 、 三苯胂 、 叠氮基三甲基硅烷 、 水 、 palladium diacetate 、 potassium carbonate 、 苯硫酚 、 三氟乙酸 、 4-(4,6-二甲氧基三嗪-2-基)-4-甲基吗啉盐酸盐 、 lithium hydroxide 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 33.17h， 生成 methyl 6'-azido-3'-(2,2-dimethyl-4,13-dioxo-3-oxa-5,12,15-triazaheptadecan-17-ylcarbamoyl)biphenyl-2-carboxylate
  参考文献：
  名称：

  Long-Lived Luminogenic Probe for Detection of RNA in a Crude Solution of Living Bacterial Cells

  摘要：

  A pre-type sensitizer for a lanthanide complex on an oligonucleotide was successfully converted to a perfect final structure in a target DNA/RNA-templated reaction, without any chemical reagent or enzyme, under neutral conditions. The final form of the lanthanide oligonucleotide provided a long-lived luminescence signal, appropriate for time-gated luminescence analysis and signal amplification. Target DNA/RNA-assisted time-gated luminescence analysis is a powerful tool for elimination of autofluorescence and detection of target RNA in living bacterial cells.

  DOI：

  10.1021/ja406724k

文献信息

• Long-Lived Luminogenic Probe for Detection of RNA in a Crude Solution of Living Bacterial Cells
  作者：Hisao Saneyoshi、Yoshihiro Ito、Hiroshi Abe

  DOI：10.1021/ja406724k

  日期：2013.9.18

  A pre-type sensitizer for a lanthanide complex on an oligonucleotide was successfully converted to a perfect final structure in a target DNA/RNA-templated reaction, without any chemical reagent or enzyme, under neutral conditions. The final form of the lanthanide oligonucleotide provided a long-lived luminescence signal, appropriate for time-gated luminescence analysis and signal amplification. Target DNA/RNA-assisted time-gated luminescence analysis is a powerful tool for elimination of autofluorescence and detection of target RNA in living bacterial cells.