2,4,4-trimethyl-valeryl chloride | 5340-42-1

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: 2,4,4-trimethyl-valeryl chloride
• 英文别名: 2,4,4-Trimethyl-valerylchlorid；2,4,4-Trimethylpentanoyl chloride
• CAS: 5340-42-1
• 化学式: C₈H₁₅ClO
• 分子量: 162.66
• InChiKey: HXUYLBGYPUIKOF-UHFFFAOYSA-N

物化性质

• 沸点：
  167.6±8.0 °C(Predicted)
• 密度：
  0.959±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,4,4-trimethyl-valeryl chloride 在 乙醚 、 铬 、 溶剂黄146 作用下， 生成 2,4,4-三甲基戊酸
  参考文献：
  名称：

  Whitmore et al., Journal of the American Chemical Society, 1941, vol. 63, p. 647

  摘要：

  DOI：
• 作为产物：
  描述：

  2,4,4-三甲基戊酸 在 氯化亚砜 作用下， 生成 2,4,4-trimethyl-valeryl chloride
  参考文献：
  名称：

  New Compounds. Methylneopentylacetic Acid (2,4,4-Trimethylpentanoic Acid), its Methyl Ester, Amide and Acetanilide

  摘要：

  DOI：

  10.1021/ja01852a601

文献信息

• ONLINE CONTINUOUS FLOW PROCESS FOR THE SYNTHESIS OF ORGANIC PEROXIDES USING HYDROGEN PEROXIDE AS RAW MATERIAL
  申请人：Shanghai Hybrid-chem Technologies

  公开号：US20200172478A1

  公开（公告）日：2020-06-04

  An online continuous flow production process for directly preparing organic peroxides by using hydrogen peroxide as a raw material. This production process uses hydrogen peroxide, catalyst, and an oxidation substrate as a raw material. Substrate will be turned to designated peroxides sequentially through oxidation and workup. This process is performed in a plug-and-produce integrated continuous flow reactor, and the raw materials are continuously fed to the reactor. So, specified peroxide can be continuously obtained at the outlet of the plug-and-produce integrated continuous flow reactor.

  一种在线连续流程生产方法，通过使用过氧化氢作为原料直接制备有机过氧化物。该生产过程使用过氧化氢、催化剂和氧化底物作为原料。底物将通过氧化和处理逐步转化为指定的过氧化物。该过程在一个即插即用的集成连续流反应器中进行，并且原料持续供给到反应器中。因此，指定的过氧化物可以在即插即用的集成连续流反应器出口处连续获得。
• Enantioselective reactions using two-component chiral phase transfer catalysts in multiphasic systems
  申请人：The Board of Trustees of the University of Illinois

  公开号：US20030097002A1

  公开（公告）日：2003-05-22

  The present invention provides multiphasic systems comprising at least one chiral selector and an achiral phase transfer catalyst, wherein said system can be used to effect enantioselective reactions or asymmetric induction reactions.

  本发明提供了包含至少一个手性选择剂和一个无手性相转移催化剂的多相系统，其中该系统可用于实现对映选择性反应或不对称诱导反应。
• Continuous Method for Producing Acyl Peroxides
  申请人：Appel Hans

  公开号：US20100036152A1

  公开（公告）日：2010-02-11

  The invention relates to a continuous method for producing acyl peroxides. According to said method, an acyl chloride, carboxylic acid anhydride or chloroformate is reacted with an organic hydroperoxide or hydrogen peroxide in at least two mixed reaction zones that are connected in series, the acyl compound, the peroxy compound and an aqueous solution of a base being supplied to the first reaction zone. The first reaction zone comprises a cycle for the two-phase reaction mixture via a heat exchanger in which the reaction mixture is cooled. The method allows the reaction to be carried out reliably and with high space-time yields.

  本发明涉及一种生产酰基过氧化物的连续方法。根据该方法，酰氯、羧酸酐或氯甲酸酯与有机过氧化物或过氧化氢在至少两个混合反应区中串联反应，酰化合物、过氧化合物和碱的水溶液被供给到第一个反应区。第一个反应区通过热交换器包含两相反应混合物的循环，其中反应混合物被冷却。该方法能够可靠地进行反应，并具有高的空间时间收率。
• Method for producing acyl peroxides
  申请人：Appel Hans

  公开号：US20100022794A1

  公开（公告）日：2010-01-28

  The invention relates to a method for producing acyl peroxides. According to said method, an acyl compound is reacted with an organic hydroperoxide and a base, the pH of the two-phase mixture so obtained is adjusted to 6 to 13, the obtained organic phase is extracted with an aqueous solution of a base and the aqueous extract is recirculated to the reaction step. The method according to the invention allows the recirculation of unreacted hydroperoxide to the reaction step.

  该发明涉及一种制备酰基过氧化物的方法。根据该方法，酰基化合物与有机过氧化物和碱反应，所得的两相混合物的pH值调节为6至13，所得的有机相与碱的水溶液萃取，水萃取物循环回反应步骤。本发明的方法允许未反应的过氧化物回收利用到反应步骤中。
• ONLINE FULLY CONTINUOUS FLOW PRODUCTION PROCESS FOR DIRECTLY PREPARING ORGANIC PEROXIDE FROM ALCOHOL OR ALKANE
  申请人：Shanghai Hybrid-Chem Technologies

  公开号：EP3666754A1

  公开（公告）日：2020-06-17

  A continuous flow production process for preparing organic peroxides directly from alcohols or alkanes takes very safe alcohols or alkanes as starting materials, and directly reacts to obtain designated peroxides. The production process is carried out in an integrated continuous flow reactor, and a safe starting source of alcohol or alkane is continuously added at the feed inlet of the integrated continuous flow reactor, and continuously provided with a designated peroxide at the discharge port of the integrated continuous flow reactor.

  一种直接从醇或烷烃制备有机过氧化物的连续流生产工艺，以非常安全的醇或烷烃为起始原料，直接反应得到指定的过氧化物。该生产工艺在一体化连续流反应器中进行，在一体化连续流反应器的进料口连续加入安全的醇或烷烃起始原料，并在一体化连续流反应器的出料口连续提供指定的过氧化物。