2-(1-phenylcyclopentyl)benzene-1,4-diol | 910378-19-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(1-phenylcyclopentyl)benzene-1,4-diol
• CAS: 910378-19-7
• 化学式: C₁₇H₁₈O₂
• 分子量: 254.329
• InChiKey: WPBYHUPFEAIABR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(1-phenylcyclopentyl)benzene-1,4-diol 、 叔丁基二苯基氯硅烷 在 咪唑 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors

  摘要：

  A search for a suitable replacement for the central norbornyl scaffold presented in the recently disclosed novel FLAP inhibitors is herein described, as well as the SAR study performed on the endo and exo-aryl groups. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.04.064
• 作为产物：
  描述：

  1-phenyl-1-(2,5-dimethoxyphenyl)ethylene 在 三甲基铝 、 三溴化硼 、 溶剂黄146 、 肼 、 锌 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 生成 2-(1-phenylcyclopentyl)benzene-1,4-diol
  参考文献：
  名称：

  Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors

  摘要：

  A search for a suitable replacement for the central norbornyl scaffold presented in the recently disclosed novel FLAP inhibitors is herein described, as well as the SAR study performed on the endo and exo-aryl groups. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.04.064

文献信息

• Diphenyl Substituted Cycloalkanes, Compositions Containing Such Compounds and Methods Of Use
  申请人：Armstrong Helen M.

  公开号：US20090197883A1

  公开（公告）日：2009-08-06

  The instant invention provides compounds of Formula (I) which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.

  本发明提供了式（I）的化合物，它们是5-脂氧酶活化蛋白抑制剂。式（I）的化合物可用作抗动脉粥样硬化、抗哮喘、抗过敏、抗炎和细胞保护剂。
• WO2006/98912
  申请人：——

  公开号：——

  公开（公告）日：——
• Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein
  作者：Dwight Macdonald、Christine Brideau、Chi Chung Chan、Jean-Pierre Falgueyret、Richard Frenette、Jocelyne Guay、John H. Hutchinson、Hélène Perrier、Peptiboon Prasit、Denis Riendeau、Philip Tagari、Michel Thérien、Robert N. Young、Yves Girard

  DOI：10.1016/j.bmcl.2008.01.105

  日期：2008.3

  The discovery and SAR of a novel series of substituted 2,2-bisaryl-bicycloheptane inhibitors of 5-lipoxygenase activating protein ( FLAP) are herein described. SAR studies have shown that 2,5-substitution on the exo-aryl group is optimal for potency. The most potent compounds in this series have an ortho-nitrogen aryl linked with a methyleneoxy as the 5-substituent and a polar group such as a urethane as the 2-substituent. One of the most potent compounds identified is the 5- benzothiazolymethoxy-2-pyridinylcarbamate derivative 2 ( FLAP IC50 = 2.8 nM) which blocks 89% of ragweed induced urinary LTE4 production in dogs ( at an I. V. dose of 2.5 mu g/kg/min). This compound inhibits calcium ionophore stimulated LTB4 production in both human polymorphonuclear ( PMN) leukocytes and human whole blood ( IC50 = 2.0 and 33 nM, respectively). (c) 2008 Elsevier Ltd. All rights reserved.
• DIPHENYL SUBSTITUTED CYCLOALKANES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE
  申请人：Merck & Co., Inc.

  公开号：EP1858513A1

  公开（公告）日：2007-11-28
• EP1858513A4
  申请人：——

  公开号：EP1858513A4

  公开（公告）日：2009-06-03