Boc-Tyr(Bzl)-D-Ala-Gly | 67706-16-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Tyr(Bzl)-D-Ala-Gly
• 英文别名: tert-butyloxycarbonyl-O-benzyl-L-tyrosyl-D-alanyl-glycine；O-benzyl-N-tert-butoxycarbonyl-tyrosyl-D-alanyl-glycine；Boc-Tyr(Bzl)-D-Ala-Gly-OH；Nalpha-t-butyloxycarbonyl-O-benzyl-L-tyrosyl-D-alanyl-glycine；2-[[(2R)-2-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(4-phenylmethoxyphenyl)propanoyl]amino]propanoyl]amino]acetic acid
• CAS: 67706-16-5
• 化学式: C₂₆H₃₃N₃O₇
• 分子量: 499.564
• InChiKey: NWGVMRXRGZATMD-UTKZUKDTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  36
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  143
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Boc-Tyr(Bzl)-D-Ala-Gly 在 钯 氢气 、 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 51.75h， 生成 tert-butyloxycarbonyl-O-benzyl-L-tyrosyl-D-alanyl-glycyl-L-phenylalanyl-L-tert-leucyl-L-arginine
  参考文献：
  名称：

  Pospisek, Jan; Bespalova, Zhanna D.; Kovarikova, Eva, Collection of Czechoslovak Chemical Communications, 1987, vol. 52, # 7, p. 1867 - 1871

  摘要：

  DOI：
• 作为产物：
  描述：

  Boc-Tyr(Bzl)-D-Ala-Gly-OBzl 生成 Boc-Tyr(Bzl)-D-Ala-Gly
  参考文献：
  名称：

  SMITHWICK, E. L. ,, JR;FREDERICKSON, R. C. A.;SHUMAN, R. T.

  摘要：

  DOI：

文献信息

• Preparation of an affinity gel for opiate receptors.
  作者：Toshiyuki Fujioka、Fumiko Inoue、Masayuki Kuriyama

  DOI：10.1248/cpb.33.4633

  日期：——

  [D-Ala2, Leu5] Enkephalin was coupled with aminohexyl-Sepharose at its C-terminal. This gel could bind solubilized opiate receptors prepared from rat brain using digitonin. This suggests that the prepared gel is a prominent candidate as an affinity gel for opiate receptors.

  [D-Ala2, Leu5] 脑啡肽在其C端的氨基酸己基-琼脂糖上偶联。这种凝胶能够结合使用皂素从大鼠脑中制备的可溶性阿片受体。这表明，制备的凝胶是阿片受体的亲和凝胶的突出候选者。
• Affinity resins for the purification of opioid-binding materials.
  作者：Toshiyuki FUJIOKA、Fumiko INOUE、Masayuki KURIYAMA

  DOI：10.1248/cpb.37.1100

  日期：——

  Two new affinity resins for the purification of opioid-binding materials were prepared. On was AH-Sepharose coupled with [D-Ala2, D-Leu5]enkephalin and the other was AF-Amino Toyopearl with [D-Ala2, Leu5]enkephalin. Solubilized-opioid receptors from rat brain were treated with these affinity resins and the materials with opioid-binding activities were purified. On sodium dodecyl sulfate (SDS)-polycrylamide gel electrophoresis, the purified materials showed one major band with a molecular weight of 62000-64000. The results suggested that the prepared resins are useful tools for the purification of opioid receptors.

  制备了两种用于纯化阿片类结合材料的新型亲和树脂。一种是与[D-Ala2, D-Leu5]enkephalin偶联的AH-Sepharose，另一种是与[D-Ala2, Leu5]enkephalin偶联的AF-Amino Toyopearl。用这些亲和树脂处理从大鼠脑中溶解的阿片受体，纯化出具有阿片结合活性的物质。在十二烷基硫酸钠（SDS）-聚丙烯酰胺凝胶电泳中，纯化的材料显示出一条分子量为 62000-64000 的主带。结果表明，所制备的树脂是纯化阿片受体的有用工具。
• Analgesic compounds
  申请人：Eli Lilly and Company

  公开号：US04264491A1

  公开（公告）日：1981-04-28

  Compounds of the formula ##STR1## and pharmaceutically acceptable non-toxic acid addition salts thereof, in which L and D, when applicable, define the chirality; R.sub.1 and R.sub.2 independently are hydrogen or C.sub.1 -C.sub.3 primary alkyl; R.sub.3 is C.sub.1 -C.sub.4 primary or secondary alkyl or --CH.sub.2 CH.sub.2 --S--CH.sub.3 ; R.sub.4 is hydrogen or C.sub.1 -C.sub.3 primary alkyl; R.sub.5 is hydrogen or C.sub.1 -C.sub.3 primary alkyl; Y is hydrogen or acetyl; and Z is ##STR2## --CH.sub.2 OH, or --CN; subject to the limitation that no more than one of R.sub.4 and R.sub.5 is C.sub.1 -C.sub.3 primary alkyl; are useful analgesic agents.

  公式为##STR1##的化合物及其药学上可接受的无毒酸盐，其中L和D（适用时）定义手性；R.sub.1和R.sub.2独立地是氢或C.sub.1-C.sub.3一级烷基；R.sub.3是C.sub.1-C.sub.4一级或二级烷基或--CH.sub.2 CH.sub.2 --S--CH.sub.3；R.sub.4是氢或C.sub.1-C.sub.3一级烷基；R.sub.5是氢或C.sub.1-C.sub.3一级烷基；Y是氢或乙酰基；Z是##STR2## --CH.sub.2 OH，或--CN；但限制为R.sub.4和R.sub.5中最多只有一个是C.sub.1-C.sub.3一级烷基。这些化合物是有用的镇痛剂。
• Tetrapeptides, methods for their preparation and their use in analgesic compositions
  申请人：ELI LILLY AND COMPANY

  公开号：EP0001684A2

  公开（公告）日：1979-05-02

  Compounds of the general formula and pharmaceutically acceptable non-toxic acid addition salts thereof, in which L and D, when applicable, define the chirality; R1 and R2 independently are hydrogen or C1-C3 primary alkyl; R3 is C1-C3 primary or secondary alkyl or-CH2CH2-S-CH3; R4 is hydrogen or C1-C3 primary alkyl; R5 is hydrogen or C1-C3 primary alkyl; Y is hydrogen or acetyl; and Zis -CH2OH, or -CN; subject to the limitation that one of R4 and R, is C1-C3 primary alkyl and the other is hydrogen; are useful analgesic agents.

  通式化合物及其药学上可接受的无毒酸加成盐，其中 L 和 D（适用时）定义手性；R1 和 R2 独立地为氢或 C1-C3 伯烷基；R3 为 C1-C3 伯烷基或仲烷基或-CH2CH2-S-CH3；R4 为氢或 C1-C3 伯烷基；R5 为氢或 C1-C3 伯烷基；Y 为氢或乙酰基；Z 为-CH2OH 或-CN；限制条件是 R4 和 R 中的一个为 C1-C3 伯烷基，另一个为氢；是有用的镇痛剂。
• Takenaka, Hiroshi; Miyake, Hiroyuki; Kojima, Yoshitane, Journal of the Chemical Society. Perkin transactions I, 1993, # 8, p. 933 - 938
  作者：Takenaka, Hiroshi、Miyake, Hiroyuki、Kojima, Yoshitane、Yasuda, Masahide、Gemba, Munekazu、Yamashita, Tetsushi

  DOI：——

  日期：——