ethyl 3-<(2,2,6,6-tetramethyl-4-piperidinyl)amino>propionate | 66651-21-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl 3-<(2,2,6,6-tetramethyl-4-piperidinyl)amino>propionate
• 英文别名: β-(2,2,6,6-Tetramethylpiperidin-4-yl)-aminopropionic acid ethyl ester；β-(2,2,6,6-Tetramethylpiperidinyl-4)-amino-propionsaeureethylester；Ethyl 3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]propanoate
• CAS: 66651-21-6
• 化学式: C₁₄H₂₈N₂O₂
• 分子量: 256.389
• InChiKey: CXQUYUROWASJFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 3-<(2,2,6,6-tetramethyl-4-piperidinyl)amino>propionate 在 lithium aluminium tetrahydride 、 三乙胺 作用下， 以 四氢呋喃 、 乙酸乙酯 为溶剂， 反应 72.0h， 生成 N,N-二(2-氯乙基)四氢-3-(2,2,6,6-四甲基-4-哌啶基)-2H-1,3,2-氧杂氮杂磷杂苯-2-胺2-氧化物
  参考文献：
  名称：

  Synthesis and study of a spin-labeled cyclophosphamide analog 3-(1-oxy-2,2,6,6-tetramethyl-4-piperidinyl)cyclophosphamide

  摘要：

  3-(1-Oxy-2,2,6,6-tetramethyl-4-piperidinyl)cyclophosphamide (7) was isolated in 36% yield following H2O2-Na2WO4 oxidation of 3-(2,2,6,6-tetramethyl-4-piperidinyl)cyclophosphamide (6), which was synthesized in three steps (25% yield) starting with 4-amino-2,2,6,6-tetramethylpiperidine. Binding of 7 to mouse liver microsomes was investigated by optical and electron spin resonance spectroscopy. Compared with the mouse liver microsomal metabolism of 1, separate incubations of 6 and an ca. 1:1 mixture of 1 and 6 gave approximately 90 and 60% less acrolein, respectively. A spin-labeled metabolite of 7, viz., N-(1-oxy-2,2,6,6-tetramethyl-4-piperidinyl)phosphoramide mustard (9), was synthesized and its intramolecular O-alkylation at pH 7.4, 37 degrees C, was studied by 31P NMR spectroscopy. Compounds 7 and 9 were inactive in screening tests against L1210 lymphoid leukemia in mice.

  DOI：

  10.1021/jm00351a021
• 作为产物：
  描述：

  2,2,6,6-四甲基-1-哌啶胺 、 丙烯酸乙酯 以84%的产率得到ethyl 3-<(2,2,6,6-tetramethyl-4-piperidinyl)amino>propionate
  参考文献：
  名称：

  Methylol derivatives of 2,2,6,6-tetraalkylpiperidines and their

  摘要：

  本发明涉及2,2,6,6-四烷基哌啶的新甲醛衍生物，其生产和用作化学附着稳定剂的聚合物，其中包含反应性OH-和NH-基团。

  公开号：

  US04223147A1

文献信息

• Carbonylation Method by Adding Secondary Sterically Hindered Amines
  申请人：Hess Dieter

  公开号：US20080188686A1

  公开（公告）日：2008-08-07

  The invention relates to a process for reaction of a carbonylatable compound using a metal complex catalyst comprising a metal of transition group VIII and an organophosphorus ligand and in the presence of a stabilizer based on a sterically hindered secondary amine.

  本发明涉及一种使用过渡金属VIII族金属和有机膦配体以及在具有基于立体阻碍的二级胺稳定剂存在下反应羰基化合物的过程。
• Process for hydroformylation of short-chain olefins in the gas phase
  申请人：Evonik Operations GmbH

  公开号：US11384042B2

  公开（公告）日：2022-07-12

  A hydroformylation process can be used for short-chain olefins, especially C2 to C5 olefins, wherein the catalyst system is heterogenized on a support that contains a porous ceramic material. Systems can also be used for carrying out said process.

  加氢甲酰化工艺可用于短链烯烃，特别是 C2 至 C5 烯烃，其中催化剂体系在含有多孔陶瓷材料的载体上异质化。系统也可用于实施上述工艺。
• Process for preparing short-chain olefins in the gas phase
  申请人：Evonik Operations GmbH

  公开号：US20210340091A1

  公开（公告）日：2021-11-04

  A hydroformylation process can be used for short-chain olefins, especially C2 to C5 olefins, wherein the catalyst system is heterogenized on a support that contains a porous ceramic material. Systems can also be used for carrying out said process.
• US4153596A
  申请人：——

  公开号：US4153596A

  公开（公告）日：1979-05-08
• US4223147A
  申请人：——

  公开号：US4223147A

  公开（公告）日：1980-09-16