5-amino-1,3,4-oxadiazole-2-carboxylic acid methyl ester | 7271-41-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-amino-1,3,4-oxadiazole-2-carboxylic acid methyl ester
• 英文别名: 2-Amino-5-methoxycarbonyl-1,3,4-oxadiazol；Methyl 5-amino-1,3,4-oxadiazole-2-carboxylate
• CAS: 7271-41-2
• 化学式: C₄H₅N₃O₃
• mdl: MFCD19205013
• 分子量: 143.102
• InChiKey: IAWFECRBIKAPGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  91.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  5-amino-1,3,4-oxadiazole-2-carboxylic acid methyl ester 在 氨 作用下， 以 甲醇 为溶剂， 反应 0.5h， 以95.5%的产率得到5-amino-1,3,4-oxadiazole-2-carboxylic acid amide
  参考文献：
  名称：

  Synthesis of 2-amino-5-cyano-1,3,4-oxadiazole and some of its derivatives

  摘要：

  Preparative syntheses have been developed for 2-amino-5-cyano-1,3,4-oxadiazole from the semicarbazone of methyl glyoxylate and some of its transformations were studied. This product is an important intermediate in the preparation of its derivatives.

  DOI：

  10.1007/bf00959674
• 作为产物：
  描述：

  methyl α-bromoglyoxylate semicarbazone 在 三乙胺 作用下， 以 苯 为溶剂， 反应 1.5h， 以82%的产率得到5-amino-1,3,4-oxadiazole-2-carboxylic acid methyl ester
  参考文献：
  名称：

  Synthesis of 2-amino-5-cyano-1,3,4-oxadiazole and some of its derivatives

  摘要：

  Preparative syntheses have been developed for 2-amino-5-cyano-1,3,4-oxadiazole from the semicarbazone of methyl glyoxylate and some of its transformations were studied. This product is an important intermediate in the preparation of its derivatives.

  DOI：

  10.1007/bf00959674

文献信息

• STOYANOVICH, F. M.;ZAXAROV, E. N.;LYSENKO, O. V.;YAROVENKO, V. N.;KRAYUSH+, IZV. AN CCCP. CEP. XIM.,(1991) N, S. 243-246
  作者：STOYANOVICH, F. M.、ZAXAROV, E. N.、LYSENKO, O. V.、YAROVENKO, V. N.、KRAYUSH+

  DOI：——

  日期：——
• Synthesis of 2-amino-5-cyano-1,3,4-oxadiazole and some of its derivatives
  作者：F. M. Stoyanovich、E. P. Zakharov、O. V. Lysenko、V. N. Yarovenko、M. M. Krayushkin

  DOI：10.1007/bf00959674

  日期：1991.1

  Preparative syntheses have been developed for 2-amino-5-cyano-1,3,4-oxadiazole from the semicarbazone of methyl glyoxylate and some of its transformations were studied. This product is an important intermediate in the preparation of its derivatives.