5-amino-2-aminomethyl-6-[4,6-diamino-3-(4-amino-3,5-dihydroxy-6-methylaminomethyltetrahydro-2H-2-pyranyloxy)-2-hydroxycyclohexyloxy]tetrahydro-2H-3,4-pyrandiol | 132102-41-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-amino-2-aminomethyl-6-[4,6-diamino-3-(4-amino-3,5-dihydroxy-6-methylaminomethyltetrahydro-2H-2-pyranyloxy)-2-hydroxycyclohexyloxy]tetrahydro-2H-3,4-pyrandiol
• 英文别名: 5-amino-2-(aminomethyl)-6-[4,6-diamino-3-[4-amino-3,5-dihydroxy-6-(methylaminomethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4-diol
• CAS: 132102-41-1
• 化学式: C₁₉H₄₀N₆O₉
• 分子量: 496.561
• InChiKey: UYLMOBHSVNWXHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.9
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  280
• 氢给体数：
  11
• 氢受体数：
  15

文献信息

• METHODS AND COMPOSITIONS RELATED TO NUCLEIC ACID BINDING ASSAYS
  申请人：Nubad, LLC

  公开号：US20140330001A1

  公开（公告）日：2014-11-06

  Small molecule fluorescent probes for established drug targets such as nucleic acids including DNA and RNA has been developed and disclosed herein. These nucleic acid probes bind to multiple DNA and RNA structures, and to sites crucial for nucleic acid function, such as DNA and RNA major grooves. Displacement of the probes by other binders such as small molecule compounds and/or proteins illicits a fluorescence change in the probe that once detected and analyzed provide binding information of these other binders of interest. Similarly, changes in fluorescence upon binding of the probes to nucleic acid have been applied to screen nucleic acid of different sequence and conformation. The nucleic acid probes and method of uses disclosed herein are advantageously suitable for high-through put screening of libraries of small molecule compounds, proteins, and nucleic acids.
• US9017943B2
  申请人：——

  公开号：US9017943B2

  公开（公告）日：2015-04-28