β-cyclomannin | 130322-66-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: β-cyclomannin
• 英文别名: beta-Cyclomannin；(1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31S,33R,35R,36R,37S,38R,39S,40R,41S,42R,43S,44R,45S,46R,47S,48R,49S)-5,10,15,20,25,30,35-heptakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecol
• CAS: 130322-66-6
• 化学式: C₄₂H₇₀O₃₅
• 分子量: 1135.0
• InChiKey: WHGYBXFWUBPSRW-FWYGNWHCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -15
• 重原子数：
  77
• 可旋转键数：
  7
• 环数：
  21.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  554
• 氢给体数：
  21
• 氢受体数：
  35

反应信息

• 作为产物：
  描述：

  生成 β-cyclomannin
  参考文献：
  名称：

  MORI, MASATO;ITO, YUKISHIGE;UZAWA, JUN;OGAWA, TOMOYA, TETRAHEDRON LETT., 31,(1990) N2, C. 3191-3194

  摘要：

  DOI：

文献信息

• Shortcut Synthesis of β-Cyclomannin from β-Cyclodextrin
  作者：Makoto Fukudome、Tomonori Shiratani、Yasuyoshi Nogami、De-Qi Yuan、Kahee Fujita

  DOI：10.1021/ol062239b

  日期：2006.12.1

  beta-Cyclomannin, a cyclic oligosaccharide consisting of seven alpha-D-mannosides connected together by the (1 -> 4) glycoside linkage, has been efficiently synthesized by the OsO4 oxidation of heptakis(2,3-didehydroxy)-beta-cyclodextrin which was prepared from beta-cyclodextrin by a five-step transformation. The novel cyclooligosaccharide not only showed water solubility high enough to meet the requirement for drug formulation but also demonstrated strong binding ability toward guest molecules.
• MORI, MASATO;ITO, YUKISHIGE;UZAWA, JUN;OGAWA, TOMOYA, TETRAHEDRON LETT., 31,(1990) N2, C. 3191-3194
  作者：MORI, MASATO、ITO, YUKISHIGE、UZAWA, JUN、OGAWA, TOMOYA

  DOI：——

  日期：——