4-(5,6,7,8,9,10-Hexahydro-[1,2,4]triazolo[4,3-a]azocin-3-yl)-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester | 801268-18-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(5,6,7,8,9,10-Hexahydro-[1,2,4]triazolo[4,3-a]azocin-3-yl)-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester
• 英文别名: Methyl 4-(5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocin-3-yl)bicyclo[2.2.2]octane-1-carboxylate
• CAS: 801268-18-8
• 化学式: C₁₈H₂₇N₃O₂
• 分子量: 317.431
• InChiKey: IZAFVIFMEVBOTI-UHFFFAOYSA-N

物化性质

• 沸点：
  476.7±55.0 °C(Predicted)
• 密度：
  1.31±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  57
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(5,6,7,8,9,10-Hexahydro-[1,2,4]triazolo[4,3-a]azocin-3-yl)-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester 在 氢氧化钾 作用下， 以 甲醇 为溶剂， 生成 4-(5,6,7,8,9,10-Hexahydro-[1,2,4]triazolo[4,3-a]azocin-3-yl)-bicyclo[2.2.2]octane-1-carboxylic acid
  参考文献：
  名称：

  Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11β-HSD1: Novel therapeutic agents for the treatment of metabolic syndrome

  摘要：

  Replacement of the pentyl chain on our original bicyclo[2.2.2]octyltriazole leads 1 and 2 has led to the discovery that heteroaryl substituted bicyclo[2.2.2]octyltriazoles are potent and selective 11 beta-hydroxysteroid dehydrogenase type I (11 beta-HSD1) inhibitors with excellent pharmacokinetic profiles. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.08.052
• 作为产物：
  描述：

  4-(甲氧羰基)双环[2.2.2]辛烷-1-羧酸 在 三乙胺 、 fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 4-(5,6,7,8,9,10-Hexahydro-[1,2,4]triazolo[4,3-a]azocin-3-yl)-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester
  参考文献：
  名称：

  Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11β-HSD1: Novel therapeutic agents for the treatment of metabolic syndrome

  摘要：

  Replacement of the pentyl chain on our original bicyclo[2.2.2]octyltriazole leads 1 and 2 has led to the discovery that heteroaryl substituted bicyclo[2.2.2]octyltriazoles are potent and selective 11 beta-hydroxysteroid dehydrogenase type I (11 beta-HSD1) inhibitors with excellent pharmacokinetic profiles. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.08.052

文献信息

• Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11β-HSD1: Novel therapeutic agents for the treatment of metabolic syndrome
  作者：Xin Gu、Jasminka Dragovic、Gloria C. Koo、Sam L. Koprak、Cheryl LeGrand、Steven S. Mundt、Kashmira Shah、Marty S. Springer、Eugene Y. Tan、Rolf Thieringer、Anne Hermanowski-Vosatka、Hratch J. Zokian、James M. Balkovec、Sherman T. Waddell

  DOI：10.1016/j.bmcl.2005.08.052

  日期：2005.12

  Replacement of the pentyl chain on our original bicyclo[2.2.2]octyltriazole leads 1 and 2 has led to the discovery that heteroaryl substituted bicyclo[2.2.2]octyltriazoles are potent and selective 11 beta-hydroxysteroid dehydrogenase type I (11 beta-HSD1) inhibitors with excellent pharmacokinetic profiles. (c) 2005 Elsevier Ltd. All rights reserved.