methyl 3-[hydroxy(methyl)phosphinoyl]-2-methylpropionate | 1204386-97-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 3-[hydroxy(methyl)phosphinoyl]-2-methylpropionate
• 英文别名: (3-Methoxy-2-methyl-3-oxopropyl)-methylphosphinic acid；(3-methoxy-2-methyl-3-oxopropyl)-methylphosphinic acid
• CAS: 1204386-97-9
• 化学式: C₆H₁₃O₄P
• 分子量: 180.141
• InChiKey: QTYUTBRKDWUMBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  甲基-次磷酸 、 甲基丙烯酸甲酯 在 三甲基溴硅烷 、 三乙胺 、 乙醇 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以80%的产率得到methyl 3-[hydroxy(methyl)phosphinoyl]-2-methylpropionate
  参考文献：
  名称：

  快速高效合成不对称次膦酸 R'P(O)OHR"

  摘要：

  已经评估了不对称次膦酸 R'P(O)OHR" 的新合成。第一个 P-C 键是由受保护的 H-次膦酸盐的碱促进 H-次膦酸盐烷基化形成的，处理起来更容易、更安全。为涉及 sila-Arbuzov 反应的第二个 P-C 键形成反应开发了一种一锅法。然后将该方法扩展到具有氨基官能团的二烷基次膦酸的合成。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

  DOI：

  10.1002/ejoc.200900852

文献信息

• Extruded flexible flat cable
  申请人：Yazaki Corporation

  公开号：US10147516B2

  公开（公告）日：2018-12-04

  An extruded flexible flat cable, which has a superior formability, flexibility, adhesiveness, and fire-retardancy, with a low manufacturing cost, is adapted for sliding door of a motor vehicle and also other parts, and has a conductor covered with an insulation layer extrude-formed with an extrusion molding method, and the insulation layer formed from a fire-retardant resin composition containing a modified polybutylene terephthalate and a fire-retardant additive, where the fire-retardant resin composition has a melting point of 170-215 degrees C. measured in reference to JIS K7121 with a differential thermal analysis at a rate of temperature increase of 10 degrees C. per minute.

  一种挤压柔性扁平电缆，具有优越的成型性、柔韧性、粘合性和阻燃性，制造成本低，适用于机动车辆的滑动门和其他部件，导体上覆盖有用挤压成型方法挤压成型的绝缘层，绝缘层由含有改性聚对苯二甲酸丁二酯和阻燃添加剂的阻燃树脂组合物形成，其中阻燃树脂组合物的熔点为 170-215 摄氏度。根据 JIS K7121 标准，在每分钟升温 10 摄氏度的条件下，用差热分析法测得。
• EXTRUDED FLEXIBLE FLAT CABLE
  申请人：Yazaki Corporation

  公开号：US20170148544A1

  公开（公告）日：2017-05-25

  An extruded flexible flat cable, which has a superior formability, flexibility, adhesiveness, and fire-retardancy, with a low manufacturing cost, is adapted for sliding door of a motor vehicle and also other parts, and has a conductor covered with an insulation layer extrude-formed with an extrusion molding method, and the insulation layer formed from a fire-retardant resin composition containing a modified polybutylene terephthalate and a fire-retardant additive, where the fire-retardant resin composition has a melting point of 170-215 degrees C. measured in reference to JIS K7121 with a differential thermal analysis at a rate of temperature increase of 10 degrees C. per minute.
• US9793030B2
  申请人：——

  公开号：US9793030B2

  公开（公告）日：2017-10-17
• Rapid and Efficient Synthesis of Unsymmetrical Phosphinic Acids R′P(O)OHR″
  作者：Cécile Fougère、Erwann Guénin、Julie Hardouin、Marc Lecouvey

  DOI：10.1002/ejoc.200900852

  日期：2009.12

  A new synthesis of unsymmetrical phosphinic acids R′P(O)OHR″ has been evaluated. The first P–C bond was formed by base-promoted H-phosphinate alkylation of a protected H-phosphinate, which is easier and safer to handle. A one-pot methodology was developed for the second P–C bond formation reaction that involves the sila-Arbuzov reaction. This methodology was then extended to the synthesis of a dialkylphosphinic

  已经评估了不对称次膦酸 R'P(O)OHR" 的新合成。第一个 P-C 键是由受保护的 H-次膦酸盐的碱促进 H-次膦酸盐烷基化形成的，处理起来更容易、更安全。为涉及 sila-Arbuzov 反应的第二个 P-C 键形成反应开发了一种一锅法。然后将该方法扩展到具有氨基官能团的二烷基次膦酸的合成。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)