1,2-di-(10-undecenyl)-3-(p-methoxybenzyl)-sn-glycerol | 188950-55-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 1,2-di-(10-undecenyl)-3-(p-methoxybenzyl)-sn-glycerol
• 英文别名: 1-[[(2R)-2,3-bis(undec-10-enoxy)propoxy]methyl]-4-methoxybenzene
• CAS: 188950-55-2
• 化学式: C₃₃H₅₆O₄
• 分子量: 516.805
• InChiKey: ZPRBDKHMDIZBDJ-MGBGTMOVSA-N

物化性质

• 沸点：
  581.0±45.0 °C(Predicted)
• 密度：
  0.936±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  10.4
• 重原子数：
  37
• 可旋转键数：
  28
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,2-di-(10-undecenyl)-3-(p-methoxybenzyl)-sn-glycerol 在 四氮唑 、 N,N-二异丙基乙胺 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 二氯甲烷 为溶剂， 反应 6.42h， 生成
  参考文献：
  名称：

  Synthesis of a tritium-labelled diether analog of phosphatidylinositol 4,5-bisphosphate

  摘要：

  The synthesis of 1-(1,2-O-diundecyl-sn-glycerylphosphoryl) 4,5-D-myo-inosityl bisphosphate and its tritiated analog are described. The convergent synthesis employed optically-pure inositol and glycerol derivatives. In the final step, hydrogenation of an alkenyl chain gave the saturated diether PIP2 and tritiation gave the high-specific activity, tritium-labelled analog.

  DOI：

  10.1002/(sici)1099-1344(199703)39:3<251::aid-jlcr964>3.0.co;2-y
• 作为产物：
  描述：

  11-溴-1-十一烯 、 (R)-3-(4-methoxybenzyloxy)propane-1,2-diol 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以82%的产率得到1,2-di-(10-undecenyl)-3-(p-methoxybenzyl)-sn-glycerol
  参考文献：
  名称：

  Synthesis of a tritium-labelled diether analog of phosphatidylinositol 4,5-bisphosphate

  摘要：

  The synthesis of 1-(1,2-O-diundecyl-sn-glycerylphosphoryl) 4,5-D-myo-inosityl bisphosphate and its tritiated analog are described. The convergent synthesis employed optically-pure inositol and glycerol derivatives. In the final step, hydrogenation of an alkenyl chain gave the saturated diether PIP2 and tritiation gave the high-specific activity, tritium-labelled analog.

  DOI：

  10.1002/(sici)1099-1344(199703)39:3<251::aid-jlcr964>3.0.co;2-y

文献信息

• Synthesis of a tritium-labelled diether analog of phosphatidylinositol 4,5-bisphosphate
  作者：Jian Chen、Glenn D. Prestwich

  DOI：10.1002/(sici)1099-1344(199703)39:3<251::aid-jlcr964>3.0.co;2-y

  日期：1997.3

  The synthesis of 1-(1,2-O-diundecyl-sn-glycerylphosphoryl) 4,5-D-myo-inosityl bisphosphate and its tritiated analog are described. The convergent synthesis employed optically-pure inositol and glycerol derivatives. In the final step, hydrogenation of an alkenyl chain gave the saturated diether PIP2 and tritiation gave the high-specific activity, tritium-labelled analog.