Methyl 1-(propan-2-ylamino)cyclobutane-1-carboxylate | 1248450-81-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methyl 1-(propan-2-ylamino)cyclobutane-1-carboxylate
• CAS: 1248450-81-8
• 化学式: C₉H₁₇NO₂
• 分子量: 171.239
• InChiKey: XIYJVSPHBDJQPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Methyl 1-(propan-2-ylamino)cyclobutane-1-carboxylate 在 铁粉 、 碳酸氢钠 作用下， 以 乙醚 、 正己烷 为溶剂， 反应 20.0h， 生成 2-chloro-8-propan-2-ylspiro[5H-pteridine-7,1'-cyclobutane]-6-one
  参考文献：
  名称：

  Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors

  摘要：

  Polo-like kinase-2 (Plk-2) is a potential therapeutic target for Parkinson's disease and this Letter describes the SAR of a series of dihydropteridinone based Plk-2 inhibitors. By optimizing both the N-8 substituent and the biaryl region of the inhibitors we obtained single digit nanomolar compounds such as 37 with excellent selectivity for Plk-2 over Plk-1. When dosed orally in rats, compound 37 demonstrated a 41-45% reduction of pS129-alpha-synuclein levels in the cerebral cortex. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.02.065
• 作为产物：
  描述：

  1-氨基环丁甲酸甲酯 、 丙酮 在 sodium acetate 、 三乙酰氧基硼氢化钠 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 生成 Methyl 1-(propan-2-ylamino)cyclobutane-1-carboxylate
  参考文献：
  名称：

  Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors

  摘要：

  Polo-like kinase-2 (Plk-2) is a potential therapeutic target for Parkinson's disease and this Letter describes the SAR of a series of dihydropteridinone based Plk-2 inhibitors. By optimizing both the N-8 substituent and the biaryl region of the inhibitors we obtained single digit nanomolar compounds such as 37 with excellent selectivity for Plk-2 over Plk-1. When dosed orally in rats, compound 37 demonstrated a 41-45% reduction of pS129-alpha-synuclein levels in the cerebral cortex. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.02.065

文献信息

• USE OF SUBSTITUTED SPIROCYCLIC SULFONAMIDOCARBOXYLIC ACIDS, CARBOXYLIC ESTERS THEREOF, CARBOXAMIDES THEREOF AND CARBONITRILES THEREOF OR SALTS THEREOF FOR ENHANCEMENT OF STRESS TOLERANCE IN PLANTS
  申请人：Frackenpohl Jens

  公开号：US20140038822A1

  公开（公告）日：2014-02-06

  Use of substituted spirocyclic sulfonamidocarboxylic acids, -carboxylic esters, -carboxamides and -carbonitriles or salts thereof for enhancement of stress tolerance in plants. The invention relates to the use of spirocyclic sulfonamidocarboxylic acids, -carboxylic esters, -carboxamides and -carbonitriles or salts thereof of the formula (I) in which the respective substituents have the meanings given in the description, for increasing stress tolerance in plants with respect to abiotic stress, and also for increasing plant growth and/or for increasing plant yield.

  使用取代的螺环磺酰胺羧酸、羧酸酯、羧酰胺和羰基腈或其盐来增强植物的耐逆性。本发明涉及使用式（I）中的螺环磺酰胺羧酸、羧酸酯、羧酰胺和羰基腈或其盐，其中各自的取代基在说明中给出，用于增强植物对非生物逆境的耐受性，以及增加植物生长和/或增加植物产量。
• Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors
  作者：Simeon Bowers、Anh P. Truong、Michael Ye、Danielle L. Aubele、Jennifer M. Sealy、R. Jeffrey Neitz、Roy K. Hom、Wayman Chan、Michael S. Dappen、Robert A. Galemmo、Andrei W. Konradi、Hing L. Sham、Yong L. Zhu、Paul Beroza、George Tonn、Heather Zhang、Jennifer Hoffman、Ruth Motter、Donald Fauss、Pearl Tanaka、Michael P. Bova、Zhao Ren、Danny Tam、Lany Ruslim、Jeanne Baker、Deepal Pandya、Linnea Diep、Kent Fitzgerald、Dean R. Artis、John P. Anderson、Marcelle Bergeron

  DOI：10.1016/j.bmcl.2013.02.065

  日期：2013.5

  Polo-like kinase-2 (Plk-2) is a potential therapeutic target for Parkinson's disease and this Letter describes the SAR of a series of dihydropteridinone based Plk-2 inhibitors. By optimizing both the N-8 substituent and the biaryl region of the inhibitors we obtained single digit nanomolar compounds such as 37 with excellent selectivity for Plk-2 over Plk-1. When dosed orally in rats, compound 37 demonstrated a 41-45% reduction of pS129-alpha-synuclein levels in the cerebral cortex. (C) 2013 Elsevier Ltd. All rights reserved.