2-亚甲基-4-氰基丁醛 | 1117-70-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-亚甲基-4-氰基丁醛
• 英文名称: 2-methylene-4-cyanobutyraldehyde
• 英文别名: 4-Formyl-pent-4-ensaeure-nitril；4-Formylpent-4-enenitrile
• CAS: 1117-70-0
• 化学式: C₆H₇NO
• mdl: MFCD19300665
• 分子量: 109.128
• InChiKey: IXMBFEQRFXTDBR-UHFFFAOYSA-N

物化性质

• 沸点：
  135 °C(Press: 50 Torr)
• 密度：
  1.0005 g/cm3(Temp: 25 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  40.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-亚甲基-4-氰基丁醛 在 aluminum isopropoxide 作用下， 生成 4-Hydroxymethyl-pent-4-ennitril
  参考文献：
  名称：

  Weiss,F. et al., Bulletin de la Societe Chimique de France, 1965, p. 490 - 493

  摘要：

  DOI：

文献信息

• [4 + 2]-Cycloadditionen von ?,?-unges�ttigten Hydrazonen. Teil 1. Pyridin-2,3-dicarboximide aus 1-(Dimethylamino)-1,4-dihydropyridin-Derivaten
  作者：Adrian Waldner

  DOI：10.1002/hlca.19880710222

  日期：1988.3.16

  [4 + 2] Cycloadditions of α,β-Unsaturated Hydrazones to Pyridine-2,3-dicarboximides via 1-(Dimethylamino)-1,4-dihydropyridine Derivatives

  [4 + 2]通过1-（二甲氨基）-1,4-二氢吡啶衍生物将α，β-不饱和Hy与吡啶-2,3-二羧酸二甲酰亚胺成环加成反应
• Process for the preparation of dialkyl, pyridine-2,3-dicarboxylates and derivatives thereof from dialkyl dichloromaleate
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0461401A1

  公开（公告）日：1991-12-18

  There is provided a process for the preparation of substituted and unsubstituted-2,3-pyridinedicarboxylate compounds by reacting a dialkyl dichloromaleate with a source of ammonia and an appropriately substituted α,β-unsaturated aldehyde or ketone.

  提供了一种制备取代和未取代的2,3-吡啶二羧酸酯化合物的方法，通过将二烷基二氯马来酸酯与氨源和适当取代的α，β-不饱和醛或酮反应。
• Process for preparing 2-halo-5-halomethylpyridines
  申请人：Reilly Industries, Inc.

  公开号：US05229519A1

  公开（公告）日：1993-07-20

  Disclosed are preferred processes for preparing a 2-halo-5-halomethylpyridine compound. The preferred processes involve cyclocondensing a 2-halo-2-halomethyl aldehyde or ketone of the formula (II) ##STR1## to form a 2-halo-2-halomethylpyridine compound of the formula (III) ##STR2## wherein X is Cl or Br, Y is a cyano group or an aminocarbonyl group, and R, R.sup.1, R.sup.2 and R.sup.3 are, independently, H or an organic radical which does not interfere with the cyclocondensation.

  本发明公开了制备2-卤代-5-卤甲基吡啶化合物的优选过程。该优选过程涉及将式（II）的2-卤代-2-卤甲基醛或酮环缩合，形成式（III）的2-卤代-2-卤甲基吡啶化合物，其中X为Cl或Br，Y为氰基或氨基甲酰基，而R、R.sup.1、R.sup.2和R.sup.3独立地为H或不干扰环缩合的有机基团。
• Process for the preparation of dialkyl pyridine -2,3-dicarboxylates and derivatives thereof from dialkyl dichloromaleate
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0548559A1

  公开（公告）日：1993-06-30

  There is provided a process for the preparation of substituted and unsubstituted-2,3-pyridinedicarboxylate compounds by reacting a dialkyl dichloromaleate with a dialkylamine to form an enamine intermediate and reacting said intermediate with an appropriately substituted α,β-unsaturated aldehyde or ketone and an ammonia source, as shown in Flow Diagam I:

  提供了一种制备取代和未取代的2,3-吡啶二甲酸酯化合物的方法，通过将二烷基二氯马来酸酯与二烷基胺反应形成恩酰亚胺中间体，并将该中间体与适当取代的α，β-不饱和醛或酮以及氨源反应，如流程图I所示。
• Process for the preparation of dialkyl pyridine-2,3-dicarboxylate and derivatives thereof from dialkyl dichlorosucciante
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0461403A1

  公开（公告）日：1991-12-18

  There is provided a process for the preparation of substituted and unsubstituted-2,3-pyridinedicarboxylate compounds by reacting a dialkyl dichlorosuccinate with a dehydrohalogenating agent, an ammonia source and an appropriately substituted α,β-unsaturated aldehyde or ketone.

  本发明提供了一种通过二烷基二氯琥珀酸酯与脱氢卤化剂、氨源和适当取代的 α、β-不饱和醛或酮反应制备取代和未取代的 2,3-吡啶二甲酸酯化合物的工艺。