β-D-GlcpA-(1→3)-D-Galp | 15038-73-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: β-D-GlcpA-(1→3)-D-Galp
• 英文别名: 3-O-β-D-Glucopyranosyl-D-galactopyranose; Solabiose；Glc(b1-3)b-Gal；(2R,3R,4S,5S,6R)-6-(hydroxymethyl)-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-2,3,5-triol
• CAS: 15038-73-0
• 化学式: C₁₂H₂₂O₁₁
• 分子量: 342.3
• InChiKey: QIGJYVCQYDKYDW-BCHYZRIQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  190
• 氢给体数：
  8
• 氢受体数：
  11

文献信息

• [EN] METHOD OF INHIBITING ABCG2 AND RELATED TREATMENTS<br/>[FR] PROCÉDÉ D'INHIBITION DE L'ABCG2 ET TRAITEMENTS ASSOCIÉS
  申请人：US HEALTH

  公开号：WO2009061770A2

  公开（公告）日：2009-05-14

  Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2 or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering peliomycin and other compounds described herein.