1,1-Diethyl-2-dimethylamino-ethanol | 23590-23-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,1-Diethyl-2-dimethylamino-ethanol
• 英文别名: dimethylaminomethyl-diethyl-carbinol；Dimethylaminomethyl-diaethyl-carbinol；3-[(Dimethylamino)methyl]pentan-3-ol
• CAS: 23590-23-0
• 化学式: C₈H₁₉NO
• 分子量: 145.245
• InChiKey: VMCSODPPPQQBSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,1-Diethyl-2-dimethylamino-ethanol 生成 3-benzoyloxy-3-dimethylaminomethyl-pentane
  参考文献：
  名称：

  DE169746

  摘要：

  公开号：
• 作为产物：
  描述：

  N,N-二甲氨基乙酸乙酯 、 ethylmagnesium bromide 生成 1,1-Diethyl-2-dimethylamino-ethanol
  参考文献：
  名称：

  Suesskind, Chemische Berichte, 1906, vol. 39, p. 226

  摘要：

  DOI：

文献信息

• Studies on Application of Amino Acid as Medicinal Agent. I. Syntheses of Amino-tert-alcohol Derivatives
  作者：SEIGORO HAYASHI、MITSURU FURUKAWA、YOKO FUJINO、NAOTO MATSUISHI、TADASHI OHKAWARA

  DOI：10.1248/cpb.17.145

  日期：——

  In order to find non-narcotic analgesics, 54 compounds of amino-tert-alcohol, in which a variety of substituent groups were involved at the carbon atom in 1-position and at the amino group, were synthesized by reacting various α-and β-amino acid esters with Grignard reagents. These amino acid esters were readily reacted with alkyl Grignard reagents to give the expected compounds. However, when bulky aromatic Grignard reagents were submitted to react, the reactions were found to stop at the stage of intermediate formation of the corresponding ketones.

  为了寻找非麻醉性镇痛药，通过将各种α-和β-氨基酸酯与格氏试剂反应，合成了54种氨基叔醇化合物，这些化合物在1-位碳原子和氨基上涉及多种取代基团。这些氨基酸酯容易与烷基格氏试剂反应，得到预期的化合物。然而，当使用庞大的芳香族格氏试剂进行反应时，发现反应停止在相应的酮中间体形成阶段。
• Paal; Weidenkaff, Chemische Berichte, 1906, vol. 39, p. 811
  作者：Paal、Weidenkaff

  DOI：——

  日期：——
• Fourneau, Journal de Pharmacie et de Chimie, 1910, vol. <7>2, p. 114
  作者：Fourneau

  DOI：——

  日期：——
• Alkoxide Compound, Thin Film-Forming Material And Method For Forming Thin Film
  申请人：Yamada Naoki

  公开号：US20080085365A1

  公开（公告）日：2008-04-10

  The alkoxide compound of the present invention is represented by general formula (I) below. The alkoxide compound of the present invention is an iron compound that can be delivered in a liquid state and is easily vaporized due to its high vapor pressure. The compound particularly enables production of thin films with excellent composition controllability, and hence is suitable for producing multi-component thin films by CVD. (In the formula, R 1 and R 2 each independently represent a hydrogen atom or C 1-4 alkyl group, R 3 and R 4 each represent a C 1-4 alkyl group, and A represents a C 1-8 alkanediyl group.)
• US7501153B2
  申请人：——

  公开号：US7501153B2

  公开（公告）日：2009-03-10