6-(fluoromethyl)tetrahydro-2H-pyran-2-one | 1337445-77-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 6-(fluoromethyl)tetrahydro-2H-pyran-2-one
• 英文别名: 6-(Fluoromethyl)oxan-2-one；6-(fluoromethyl)oxan-2-one
• CAS: 1337445-77-8
• 化学式: C₆H₉FO₂
• 分子量: 132.135
• InChiKey: LDZNTDBHIVXUPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-己烯酸 在 Selectfluor 作用下， 反应 30.0h， 以21%的产率得到5-(2-fluoroethyl)dihydrofuran-2(3H)-one
  参考文献：
  名称：

  Fluorolactonization of unsaturated carboxylic acids with F-TEDA-BF4 in ionic liquids

  摘要：

  Fluorolactonization of unsaturated carboxylic acids under action of the electrophilic reagent F-TEDA-BF4 in ionic liquids (ILs) has been studied. This reaction proceeds in ILs faster and provides a better stereoselectivity in comparison to acetonitrile as reaction media. Gem-difluorinated gamma-lactones have been synthesized by interaction of unsaturated carboxylic acids with F-TEDA-BF4 in ILs. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.07.124

文献信息

• Fluorolactonization of unsaturated carboxylic acids with F-TEDA-BF4 in ionic liquids
  作者：Yurii A. Serguchev、Lyudmila F. Lourie、Maxim V. Ponomarenko、Eduard B. Rusanov、Nikolai V. Ignat’ev

  DOI：10.1016/j.tetlet.2011.07.124

  日期：2011.10

  Fluorolactonization of unsaturated carboxylic acids under action of the electrophilic reagent F-TEDA-BF4 in ionic liquids (ILs) has been studied. This reaction proceeds in ILs faster and provides a better stereoselectivity in comparison to acetonitrile as reaction media. Gem-difluorinated gamma-lactones have been synthesized by interaction of unsaturated carboxylic acids with F-TEDA-BF4 in ILs. (C) 2011 Elsevier Ltd. All rights reserved.