Hex-5-enoic acid allyl-prop-2-ynyl-amide | 441771-31-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Hex-5-enoic acid allyl-prop-2-ynyl-amide
• 英文别名: N-prop-2-enyl-N-prop-2-ynylhex-5-enamide
• CAS: 441771-31-9
• 化学式: C₁₂H₁₇NO
• 分子量: 191.273
• InChiKey: HWUMVPMAMVGVHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Hex-5-enoic acid allyl-prop-2-ynyl-amide 在 potassium tert-butylate 、 叔丁醇 作用下， 以 四氢呋喃 为溶剂， 反应 8.0h， 生成 Hex-5-enoic acid allyl-prop-1-ynyl-amide
  参考文献：
  名称：

  The First Successful Base-Promoted Isomerization of Propargyl Amides to Chiral Ynamides. Applications in Ring-Closing Metathesis of Ene−Ynamides and Tandem RCM of Diene−Ynamides

  摘要：

  [GRAPHICS]A highly useful sequence of reactions is described here. These reactions consist of the first successful base-induced isomerizations of propargyl amides to chiral ynamides, applications of these novel ynamides in ring-closure metathesis leading to chiral 2-amidodienes useful for Diels-Alder cycloadditions, and the first successful tandem RCM of diene-ynamides.

  DOI：

  10.1021/ol020097p
• 作为产物：
  描述：

  5-己烯酸 在 4-二甲氨基吡啶 、 草酰氯 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 14.0h， 生成 Hex-5-enoic acid allyl-prop-2-ynyl-amide
  参考文献：
  名称：

  The First Successful Base-Promoted Isomerization of Propargyl Amides to Chiral Ynamides. Applications in Ring-Closing Metathesis of Ene−Ynamides and Tandem RCM of Diene−Ynamides

  摘要：

  [GRAPHICS]A highly useful sequence of reactions is described here. These reactions consist of the first successful base-induced isomerizations of propargyl amides to chiral ynamides, applications of these novel ynamides in ring-closure metathesis leading to chiral 2-amidodienes useful for Diels-Alder cycloadditions, and the first successful tandem RCM of diene-ynamides.

  DOI：

  10.1021/ol020097p

文献信息

• The First Successful Base-Promoted Isomerization of Propargyl Amides to Chiral Ynamides. Applications in Ring-Closing Metathesis of Ene−Ynamides and Tandem RCM of Diene−Ynamides
  作者：Jian Huang、Hui Xiong、Richard P. Hsung、C. Rameshkumar、Jason A. Mulder、Tyler P. Grebe

  DOI：10.1021/ol020097p

  日期：2002.7.1

  [GRAPHICS]A highly useful sequence of reactions is described here. These reactions consist of the first successful base-induced isomerizations of propargyl amides to chiral ynamides, applications of these novel ynamides in ring-closure metathesis leading to chiral 2-amidodienes useful for Diels-Alder cycloadditions, and the first successful tandem RCM of diene-ynamides.