(1RS, 12bSR)-1-Ethyl-1,2,3,4,5,6,7,12b-octahydroindolo<2,3-a>quinolizin-1-carbaldehyd | 51152-49-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (1RS, 12bSR)-1-Ethyl-1,2,3,4,5,6,7,12b-octahydroindolo<2,3-a>quinolizin-1-carbaldehyd
• 英文别名: 1-ethyl-3,4,6,7,12,12b-hexahydro-2H-indolo[2,3-a]quinolizine-1-carbaldehyde
• CAS: 51152-49-9
• 化学式: C₁₈H₂₂N₂O
• 分子量: 282.385
• InChiKey: DCEPIHDYWSOBGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  36.1
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Process for the preparation of vinpocetine and apovincamine
  申请人：Linnea S.A.

  公开号：EP2168963A1

  公开（公告）日：2010-03-31

  A process for the preparation of vinpocetine and apovincamine, wherein said process comprises the steps of: (1) preparing a solution of the compound of formula (II) below and an organic or inorganic base in a polar aprotic solvent, and (2) adding an alkyl haloacetate to the solution of step (1) under controlled temperature conditions.

  一种制备文波西汀和缺脱文汀的方法，其中所述方法包括以下步骤：(1) 在极性非质子溶剂中制备化合物（II）的溶液以及有机或无机碱，并(2) 在受控温度条件下向步骤（1）的溶液中加入烷基卤代乙酸酯。
• A process for the synthesis of vincamine and related indole alkaloids
  申请人：Mora, Paolo Corvi

  公开号：EP0045918A1

  公开（公告）日：1982-02-17

  A process is taught for the synthesis of vincamine and related indole alkaloids, according to which, through only two steps and through a novel synthesis intermediate, namely the glycidic ester, having the formula wherein R" represents -COOCH3 or -COOCH2CH3, 1-ethyl-1,2,3,4,5,6,7,12b-octahydroindole- [2,3-a] -quinolizine-1-carbaldehyde is reacted with a haloester in the presence of a base and the glycidic ester is converted to vincamine or apovincamine or like esters by reaction with a Lewis acid or a mineral acid, the reaction products being subsequently separated by chromatography.

  本发明提出了一种合成长春胺和相关吲哚生物碱的工艺，根据该工艺，只需两个步骤，通过一种新型合成中间体，即具有式中 R "代表-COOCH3或-COOCH2CH3的缩水甘油酯，1-乙基-1,2,3,4,5,6,7,12b-八氢吲哚-[2,3-a] -喹嗪-1-甲醛在碱存在下与卤代酯反应，缩水甘油酯通过与路易斯酸或矿物酸反应转化为长春胺或阿朴长春胺或类似酯，反应产物随后通过色谱法分离。
• PROCESS FOR THE PREPARATION OF VINPOCETINE AND APOVINCAMINE
  申请人：Linnea S.A.

  公开号：EP2344489B1

  公开（公告）日：2014-01-22