gulofuranoside | 36574-18-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: gulofuranoside
• 英文别名: gulofuranose；(3R,4S,5S)-5-[(1R)-1,2-dihydroxyethyl]oxolane-2,3,4-triol
• CAS: 36574-18-2
• 化学式: C₆H₁₂O₆
• 分子量: 180.158
• InChiKey: AVVWPBAENSWJCB-YIDFTEPTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  110
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• [EN] PREPARATION OF MONOSACCHARIDE DERIVATIVES<br/>[FR] PREPARATION DE DERIVES DE MONOSACCHARIDE
  申请人：RANBAXY LAB LTD

  公开号：WO2004071515A1

  公开（公告）日：2004-08-26

  Process for the preparation of monosaccharide derivatives, providing industrial advantages, including convenience, safety, and economic advantages. The monosaccharide derivatives can be used for the inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies.

  制备单糖衍生物的过程，提供了工业优势，包括便利、安全和经济优势。这些单糖衍生物可以用于抑制和预防细胞黏附和细胞黏附介导的病理过程。
• [EN] PROCESS FOR THE SYNTHESIS OF BASE ADDITION SALTS OF 2,3-0-ISOPROPYLIDENE-1-0-SUBSTITUTED-5,6-DIDEOXY-5-N- (4-(2-HYDROXY-2-OXOETHYL)-PHENYLAMINOCARBONYL) AMINO-L-GULOFURANOSIDES<br/>[FR] PROCEDE DE SYNTHESE DES SELS D'ADDITION DE BASE DE 5,6-DIDEOXY-5-N-(4-(2-HYDROXY-2-OXOETHYL)-PHENYLAMINOCARBONYL) AMINO-L-GULOFURANOSIDES SUBSTITUES PAR 2,3-0-ISOPROPYLIDENE-1-0
  申请人：RANBAXY LAB LTD

  公开号：WO2004099229A1

  公开（公告）日：2004-11-18

  The present invention relates to processes for the synthesis of base addition salts of particular ß-L- gulofuranosides. More specifically, the invention relates to synthetic processes for making base addition salts of 2,3-O-isopropylidene-1-O-substituted-5,6-dideoxy-5-N-[4-(2-hydroxy-2-oxoethy)-phenylaminocarbony]amino-ß-L-gulofuranosides.

  本发明涉及合成特定ß-L-葡萄糖呋喃糖苷的碱加成盐的过程。更具体地说，本发明涉及合成2,3-O-异丙基亚甲基-1-O-取代-5,6-二脱氧-5-N-[4-(2-羟基-2-氧乙基)-苯胺羧酰基]氨基-ß-L-葡萄糖呋喃糖苷的碱加成盐的合成过程。
• [EN] BASE ADDITION SALTS OF MONOSACCHARIDES DERIVATIVES AS INHIBITORS OF AIRWAY HYPER REACTIVITY AND AIRWAY INFLAMMATION<br/>[FR] SELS D'ADDITION BASIQUES DE DERIVES MONOSACCHARIDES UTILISES EN TANT QU'INHIBITEURS DE L'HYPERREACTIVITE DES VOIES AERIENNES ET DES INFLAMMATIONS DES VOIES AERIENNES
  申请人：RANBAXY LAB LTD

  公开号：WO2005092908A1

  公开（公告）日：2005-10-06

  The present invention relates to the use of base addition salts of Formula I for treating or preventing airway hyper reactivity and airway inflammation in a mammal. It in turn may also prove a potential benefit in the treatment of Chronic Obstructive Pulmonary Disease (COPD).

  本发明涉及使用式I的碱盐来治疗或预防哺乳动物的气道高反应性和气道炎症。这可能在慢性阻塞性肺疾病（COPD）的治疗中也有潜在的益处。
• Ascorbic acid ethers and related compounds
  申请人：ELI LILLY AND COMPANY

  公开号：EP0086554A1

  公开（公告）日：1983-08-24

  Ethers of ascorbic acid, isoascorbic acid, dihydroascorbic acid, dihydroisoascorbic acid, deoxyascorbic acid, and scorbamic acid, and ketals and acetals thereof, having angiogenesis and arthritis inhibiting properties, are provided.

  本研究提供了具有血管生成和关节炎抑制特性的抗坏血酸、异抗坏血酸、二氢抗坏血酸、二氢异抗坏血酸、脱氧抗坏血酸和氨基甲酸的醚及其酮和乙缩醛。
• ANTI-PROLIFERATIVE AND ANTI-INFLAMMATORY COMPOUNDS: 5- OR 6-DEOXY HEXOSE MONOSACCHARIDES HAVING A SATURATED NITROGEN-CONTAINING HETEROCYCLE AT THE 5- OR 6-POSITION BOUND THROUGH THE NITROGEN ATOM
  申请人：GREENWICH PHARMACEUTICALS INCORPORATED

  公开号：EP0581916A1

  公开（公告）日：1994-02-09