2-amino-2-deoxy-L-idose | 14307-12-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-amino-2-deoxy-L-idose
• 英文别名: L-ido-2-Amino-3,4,5,6-tetrahydroxy-hexanal；2-Amino-2-desoxy-L-idose；L-Idosamin；(2R,3R,4S,5S)-2-amino-3,4,5,6-tetrahydroxyhexanal
• CAS: 14307-12-1
• 化学式: C₆H₁₃NO₅
• 分子量: 179.173
• InChiKey: FZHXIRIBWMQPQF-UNTFVMJOSA-N

物化性质

• 沸点：
  532.5±50.0 °C(Predicted)
• 密度：
  1.491±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  124
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• 2,5-bis(tetrahydroxybutyl)pyrazines for the treatment of osteoarthritis and rheumatoid arthritis
  申请人：ROTTAPHARM S.P.A.

  公开号：EP1704862A1

  公开（公告）日：2006-09-27

  Use in the prevention and/or in the treatment of Osteoarthritis and Rheumatoid Arthritis of 2,5-Bis(tetrahydroxybutyl)pyrazines, compounds of formula (I), is disclosed. Compounds of the invention act simultaneously on cartilage matrix degradation and on nitric oxide and prostaglandin E2 production.

  本发明揭示了2,5-双(四羟基丁基)吡嗪化合物在骨关节炎和类风湿性关节炎的预防和/或治疗中的用途。该发明的化合物同时对软骨基质降解、一氧化氮和前列腺素E2的产生起作用。
• NOVEL SMALL MOLECULE IMMUNE AGONISTS AND IMMUNE TARGETING COMPOUNDS AND APPLICATION THEREOF
  申请人：SHENZHEN UNIVERSITY

  公开号：US20210038605A1

  公开（公告）日：2021-02-11

  Provided is a series of homologous small molecule immune agonists and novel bifunctional immune targeting compounds having targeting and immune activation functions, which are obtained by coupling the small molecule immune agonists to targeting drugs. The resulting immune targeting compounds are beneficial for enhancing immune activation effects, and anti-tumor and other disease fighting effects of the targeting drug. The enhanced effect is produced from a synergy of immunological anti-tumor factors (such as IFN-γ) and inhibition at pathogenic targeting sites.