N,N-diallyl-2,2-dimethylpropanamide | 60901-59-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N-diallyl-2,2-dimethylpropanamide
• 英文别名: tert-butyl N,N-diallylcarbamate；N,N-Diallylpivalamide；2,2-dimethyl-N,N-bis(prop-2-enyl)propanamide
• CAS: 60901-59-9
• 化学式: C₁₁H₁₉NO
• mdl: MFCD03375926
• 分子量: 181.278
• InChiKey: DUBSFCBNHNWHDY-UHFFFAOYSA-N

物化性质

• 沸点：
  251.8±29.0 °C(Predicted)
• 密度：
  0.885±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.545
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N,N-diallyl-2,2-dimethylpropanamide 在 萘 、 lithium 作用下， 反应 1.0h， 以50%的产率得到2,2-二甲基己-5-烯-3-酮
  参考文献：
  名称：

  Generation of allylic and benzylic organolithium reagents from the corresponding ester, amide, carbonate, carbamate and urea derivatives

  摘要：

  The reaction of different allylic and benzylic non-enolisable esters or amides (1), carbonates (4), carbamates (6, 7) and ureas (8) with an excess of lithium powder and a catalytic amount of naphthalene (10%) in the presence of an electrophile [iPrCHO, tBuCHO, PhCHO, Me2CO, Et2CO, (CH2)(5)CO, Ph2CO, MeSiCl] in THF at different temperatures (-78, -30 or 0 degrees C) leads, after hydrolysis with water, to the corresponding allylated or benzylated products (2). (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00610-9
• 作为产物：
  描述：

  三甲基乙酰氯 、 二烯丙基胺 在 三乙胺 作用下， 以89%的产率得到N,N-diallyl-2,2-dimethylpropanamide
  参考文献：
  名称：

  Generation of allylic and benzylic organolithium reagents from the corresponding ester, amide, carbonate, carbamate and urea derivatives

  摘要：

  The reaction of different allylic and benzylic non-enolisable esters or amides (1), carbonates (4), carbamates (6, 7) and ureas (8) with an excess of lithium powder and a catalytic amount of naphthalene (10%) in the presence of an electrophile [iPrCHO, tBuCHO, PhCHO, Me2CO, Et2CO, (CH2)(5)CO, Ph2CO, MeSiCl] in THF at different temperatures (-78, -30 or 0 degrees C) leads, after hydrolysis with water, to the corresponding allylated or benzylated products (2). (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00610-9

文献信息

• Novel Tetrahydro-1H-Pyrido[4,3-b] Indole Derivatives as CB1 Receptor Ligands
  申请人：Cheng Yun-Xing

  公开号：US20100113502A1

  公开（公告）日：2010-05-06

  Compounds of formulae I, or pharmaceutically acceptable salts thereof: wherein R 1 , R 2 and R 3 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

  化合物I的公式，或其药学上可接受的盐：其中R1、R2和R3如规范中所定义，以及包括这些化合物的盐和药物组合物已被制备。它们在治疗中很有用，特别是在疼痛管理方面。
• Hoveyda–Grubbs first generation type catalyst immobilized on mesoporous molecular sieves
  作者：Jakub Pastva、Jiří Čejka、Naděžda Žilková、Oto Mestek、Mojca Rangus、Hynek Balcar

  DOI：10.1016/j.molcata.2013.06.006

  日期：2013.11

  New heterogeneous, reusable catalysts for olefin metathesis have been prepared by immobilizing the Hoveyda-Grubbs first generation type alkylidene (commercially available as the Zhan catalyst-1C) on siliceous mesoporous molecular sieves with different pore sizes and architectures (SBA-15, SBA-16, MCM-41 and MCM-48) having the surface modified with molecules bearing dicyclohexylphosphine (PCy2) end groups. Resulting novel heterogenized catalysts proved high activity in ring-closing metathesis (RCM) of 1,7-octadiene, diethyl diallylmalonate, tert-butyl N,N-diallylcarbamate and N,N-diallyl-2,2,2-trifluoroacetamide, in homometathesis of 1-decene, 5-hexenyl acetate and methyl 10-undecenoate, and in cross-metathesis (CM) of allylbenzene with cis-1,4-diacetoxy-2-butene. The catalytic activity decreased with decreasing pore size of supports in the order SBA-15 > MCM-48 > SBA-16 and MCM-41. Filtration test suggested that the solid catalyst was responsible for the catalytic activity. Catalysts were easily separated from the reaction mixtures and products of low levels of Ru concentration were obtained. (c) 2013 Elsevier B.V. All rights reserved.
• Krompiec; Suwinski; Grobelny, Polish Journal of Chemistry, 1997, vol. 71, # 6, p. 747 - 753
  作者：Krompiec、Suwinski、Grobelny、Wagner

  DOI：——

  日期：——
• Krompiec; Suwinski; Gibas, Polish Journal of Chemistry, 1996, vol. 70, # 1, p. 133 - 134
  作者：Krompiec、Suwinski、Gibas、Grobelny

  DOI：——

  日期：——
• Structure elucidation of a zwitterionic 2-oxazoline obtained by cyclofunctionalization of n-acetyldiallylamine with tellurium tetrachloride
  作者：Jan Bergman、Jan Sidén、Knut Maartmann-Moe

  DOI：10.1016/s0040-4020(01)91812-5

  日期：1984.1