1-[3-(2-Aminoethoxy)phenyl]ethanone | 687985-73-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[3-(2-Aminoethoxy)phenyl]ethanone
• CAS: 687985-73-5
• 化学式: C₁₀H₁₃NO₂
• mdl: MFCD12024869
• 分子量: 179.22
• InChiKey: HZQDOCURSMJHFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Growth Hormone Conjugate with Increased Stability
  申请人：Johansen Nils Langeland

  公开号：US20110263501A1

  公开（公告）日：2011-10-27

  Novel growth hormone conjugates comprising a growth hormone compound (GH) and a growth hormone binding protein (GHBP) are disclosed. The invention also encompasses a novel derivatization method for producing stable, long-lasting conjugate (hGH-GHBP) by site specific conjugation. The novel GH-GHBP conjugates have an extended half-life in circulation that facilitates therapeutic use of the protein. The GH-GHBP conjugates exhibit pharmacological properties such as increased functional in vivo half-life, improved renal filtration, improved protease protection and albumin binding.

  揭示了包括生长激素化合物（GH）和生长激素结合蛋白（GHBP）的新型生长激素共轭物。该发明还涵盖了一种用于通过位点特异性结合制备稳定、持久的共轭物（hGH-GHBP）的新型衍生化方法。新型GH-GHBP共轭物在循环中具有延长的半衰期，有助于蛋白质的治疗应用。GH-GHBP共轭物表现出诸如增加的体内功能半衰期、改善的肾脏过滤、改善的蛋白酶保护和结合白蛋白等药理特性。
• Transglutaminase mediated conjugation of peptides
  申请人：Johansen Langeland Nils

  公开号：US20070105770A1

  公开（公告）日：2007-05-10

  Methods for conjugating peptides are provided comprising i) reacting a peptide with a first compound comprising a functional group in the presence of a transglutaminase capable of incorporating said compound into the peptide to form a transaminated peptide, and ii) reacting said transaminated peptide with e.g. a functionalized polymer capable of reacting with the functional group incorporated in the peptide in the enzymatic reaction.

  提供了肽共轭的方法，包括：i)在转谷氨酰胺酶的存在下，将肽与含有官能基的第一化合物反应，使该化合物被并入肽中，形成转氨基化肽；ii)将所述转氨基化肽与具有官能基的聚合物反应，使其与在酶催化反应中并入肽中的官能基发生反应。
• Transglutaminase Mediated Conjugation of Peptides
  申请人：Johansen Nils Langeland

  公开号：US20090264366A1

  公开（公告）日：2009-10-22

  Methods for conjugating peptides are provided comprising i) reacting a peptide with a first compound comprising a functional group in the presence of a transglutaminase capable of incorporating said compound into the peptide to form a transaminated peptide, and ii) reacting said transaminated peptide with e.g. a functionalized polymer capable of reacting with the functional group incorporated in the peptide in the enzymatic reaction.

  本文提供了肽共轭的方法，包括：i）在转酰胺酶存在下，将肽与第一化合物反应，该化合物包含一个官能团，能够将该化合物并入肽中形成转酰胺肽；ii）将转酰胺肽与具有官能团的聚合物反应，该聚合物能够与在酶反应中并入肽中的官能团反应。
• TRANSGLUTAMINASE MEDIATED CONJUGATION OF PEPTIDES
  申请人：NOVO NORDISK A/S

  公开号：EP1708755A2

  公开（公告）日：2006-10-11
• MODULATING ENZYMATIC PROCESSES BY ADDITION OF DIOLCONTAINING SUBSTANCES
  申请人：Novo Nordisk Health Care AG

  公开号：EP2121952A1

  公开（公告）日：2009-11-25