N,N'-hexanediyl-bis-butyramide | 35152-02-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N,N'-hexanediyl-bis-butyramide
• 英文别名: N,N'-Hexandiyl-bis-butyramid；N,N'-Dibutyrylhexamethylendiamin；N-(6-Butanamidohexyl)butanamide；N-[6-(butanoylamino)hexyl]butanamide
• CAS: 35152-02-4
• 化学式: C₁₄H₂₈N₂O₂
• 分子量: 256.389
• InChiKey: VLOWJRRWUWYFOJ-UHFFFAOYSA-N

物化性质

• 熔点：
  137-139 °C
• 沸点：
  488.7±28.0 °C(Predicted)
• 密度：
  0.944±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  18
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  丁酸 、 1,6-己二异氰酸酯 生成 N,N'-hexanediyl-bis-butyramide
  参考文献：
  名称：

  ORGANIC ANTI-FOAMING AGENTS

  摘要：

  DOI：

  10.1021/jo01124a001

文献信息

• Lead optimization of HMBA to develop potent HEXIM1 inducers
  作者：Bo Zhong、Rati Lama、Wannarasmi Ketchart、Monica M. Montano、Bin Su

  DOI：10.1016/j.bmcl.2014.01.025

  日期：2014.3

  The potency of a series of Hexamethylene bis-acetamide (HMBA) derivatives inducing Hexamethylene bis-acetamide inducible protein 1 (HEXIM1) was determined in LNCaP prostate cancer cells. Several compounds with unsymmetrical structures showed significantly improved activity. Distinct from HMBA, these analogs have increased hydrophobicity and can improve the short half-life of HMBA, which is one of the factors that have limited the application of HMBA in clinics. The unsymmetrical scaffolds of the new analogs provide the basis for further lead optimization of the compounds using combinatorial chemistry strategy. Published by Elsevier Ltd.
• STABILIZED HIGH-DENSITY POLYETHYLENE COMPOSITION WITH IMPROVED RESISTANCE TO DETERIORATION AND STABILZER SYSTEM
  申请人：Equistar Chemicals LP

  公开号：EP2917276B1

  公开（公告）日：2018-07-18
• SILICONE-BASED CURABLE COMPOSITION CONTAINING POLYCYCLIC HYDROCARBON GROUP
  申请人：TABEI Eiichi

  公开号：US20080071023A1

  公开（公告）日：2008-03-20

  The present invention provides a curable composition that has a high degree of hardness, excellent heat resistance and crack resistance, and is useful as a sealing material for optical elements and the like. The curable composition according to the present invention is a polycyclic hydrocarbon group-containing silicone-based curable composition comprising: (A) an addition reaction product of (a) a specific organosilicon compound containing two hydrosilyl groups, and (b) a polycyclic hydrocarbon containing two addition reactive carbon-carbon double bonds within each molecule, wherein the addition reaction product contains at least two addition reactive carbon-carbon double bonds within each molecule, (B) a compound containing three or more hydrogen atoms bonded to silicon atoms within each molecule, (C) a hydrosilylation reaction catalyst, and (D) a stabilizer containing a hindered amine structure and a phenol structure within each molecule.
• STABILIZED HIGH-DENSITY POLYETHYLENE COMPOSITION WITH IMPROVED RESISTANCE TO DETERIORATION AND STABILIZER SYSTEM
  申请人：SHERMAN, JR. ROBERT L.

  公开号：US20140127438A1

  公开（公告）日：2014-05-08

  The disclosure relates to a high-density polyethylene (HDPE) composition with resistance to deterioration in the presence of chlorinated and non-chlorinated water at temperatures in the range of about 0° C. to about 100° C., due to a particular stabilizer system which is composed of a hindered phenol antioxidant, a phosphonite or phosphine antioxidant, and a natural or synthetic hydrotalcite. The stabilizer system is specifically tailored to protect the HDPE as well as other polyolefins against deterioration and degradation.
• [EN] STABILIZED HIGH-DENSITY POLYETHYLENE COMPOSITION WITH IMPROVED RESISTANCE TO DETERIORATION AND STABILZER SYSTEM<br/>[FR] COMPOSITION DE POLYÉTHYLÈNE HAUTE DENSITÉ STABILISÉ AYANT UNE RÉSISTANCE AMÉLIORÉE À LA DÉGRADATION ET SYSTÈME DE STABILISANT
  申请人：EQUISTAR CHEM LP

  公开号：WO2014074596A1

  公开（公告）日：2014-05-15

  The disclosure relates to a high-density polyethylene (HDPE) composition with resistance to deterioration in the presence of chlorinated and non-chlorinated water at temperatures in the range of about 0 °C to about 100 °C, due to a particular stabilizer system which is composed of a hindered phenol antioxidant, a phosphonite or phosphine antioxidant, and a natural or synthetic hydrotalcite. The stabilizer system is specifically tailored to protect the HDPE as well as other polyolefins against deterioration and degradation.