4-(4-hydroxy-3-methoxy-phenyl)-3,5-diphenyl-4,5-dihydro-1H-pyrrolo[3,4-c]pyrazol-6-one | 337922-51-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(4-hydroxy-3-methoxy-phenyl)-3,5-diphenyl-4,5-dihydro-1H-pyrrolo[3,4-c]pyrazol-6-one
• 英文别名: 4-(4-hydroxy-3-methoxyphenyl)-3,5-diphenyl-1,4-dihydropyrrolo[3,4-c]pyrazol-6-one
• CAS: 337922-51-7
• 化学式: C₂₄H₁₉N₃O₃
• 分子量: 397.433
• InChiKey: QPOSHVSRJBAGDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  78.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-benzoyl-3-hydroxy-5-(4-hydroxy-3-methoxy-phenyl)-1,5-dihydro-pyrrol-2-one 在 hydrazine hydrate 、 溶剂黄146 作用下， 反应 0.5h， 以56.3%的产率得到4-(4-hydroxy-3-methoxy-phenyl)-3,5-diphenyl-4,5-dihydro-1H-pyrrolo[3,4-c]pyrazol-6-one
  参考文献：
  名称：

  [EN] PHOSPHODIESTERASE INHIBITORS
  [FR] INHIBITEURS DE PHOSPHODIESTÉRASE

  摘要：

  公开号：

  WO2012046030A3

文献信息

• SCREENING METHODS FOR IDENTIFYING PLASMODIUM PROTEASES INHIBITORS
  申请人：Barale Jean-Christophe

  公开号：US20140134657A1

  公开（公告）日：2014-05-15

  The invention relates to the field of parasitology. Methods and peptidic substrate for screening and identifying inhibitors of Plasmodium are described. Also described are compounds identified by these screening methods, including more particularly inhibitors of Plasmodium subtilisin-like proteases. The invention also concerns anti-malaria compounds, anti-malaria compositions, and uses thereof for preventing, treating, improving, and/or alleviating a Plasmodium infection in a subject, and more Plasmodium vivax and/or by Plasmodium falciparum human infections.
• US9404142B2
  申请人：——

  公开号：US9404142B2

  公开（公告）日：2016-08-02
• [EN] SCREENING METHODS FOR IDENTIFYING PLASMODIUM PROTEASES INHIBITORS<br/>[FR] PROCÉDÉS DE CRIBLAGE POUR L'IDENTIFICATION D'INHIBITEURS DE PROTÉASES DE PLASMODIUM
  申请人：PASTEUR INSTITUT

  公开号：WO2012073066A1

  公开（公告）日：2012-06-07

  The invention relates to the field of parasitology. Methods and peptidic substrate for screening and identifying inhibitors of Plasmodium are described. Also described are compounds identified by these screening methods, including more particularly inhibitors of Plasmodium subtilisin-like proteases. The invention also concerns anti-malaria compounds, anti-malaria compositions, and uses thereof for preventing, treating, improving, and/or alleviating a Plasmodium infection in a subject, and more Plasmodium vivax and/or by Plasmodium falciparum human infections.
• [EN] PHOSPHODIESTERASE INHIBITORS<br/>[FR] INHIBITEURS DE PHOSPHODIESTÉRASE
  申请人：RIOTECH PHARMACEUTICALS LTD

  公开号：WO2012046030A3

  公开（公告）日：2012-08-09