4,7,10,13,16-Pentaoxanonadecane | 28830-99-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4,7,10,13,16-Pentaoxanonadecane
• 英文别名: 1-[2-[2-[2-(2-propoxyethoxy)ethoxy]ethoxy]ethoxy]propane
• CAS: 28830-99-1
• 化学式: C₁₄H₃₀O₅
• 分子量: 278.38
• InChiKey: POPQOOKGONERGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  19
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• MDM2-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE
  申请人：Arvinas, Inc.

  公开号：US20170008904A1

  公开（公告）日：2017-01-12

  The description relates to MDM2 binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the description provides compounds, which contain on one end a ligand which binds to the MDM2 E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.

  描述涉及MDM2结合化合物，包括包含相同结构的双功能化合物，这些化合物可作为靶向泛素化的调节剂，特别是根据本发明抑制各种多肽和其他蛋白质的化合物。具体而言，描述提供了一种化合物，其一端含有结合到MDM2 E3泛素连接酶的配体，另一端含有结合到靶蛋白的基团，使得靶蛋白与泛素连接酶靠近，以促使该蛋白的降解（和抑制）。可以合成出一系列具有广泛药理活性的化合物，与几乎任何类型的靶向多肽的降解/抑制一致。
• METHOD FOR PRODUCING CARBONATE COMPOUND
  申请人：Asahi Glass Company, Limited

  公开号：US20150284314A1

  公开（公告）日：2015-10-08

  The present invention relates to a production process capable of selectively producing various kinds of carbonate compounds without restraint in high yields without using toxic compounds such as phosgene and crown ethers, without producing corrosive gases such as hydrogen chloride as a by-product, and without necessity of removing the chloroform as a by-product by distillation, and to a method for producing a carbonate compound, containing reacting compound (1) with a compound having an OH group in the presence of a metal salt and 0.2 to 4.0 mol of compound (2) per mol of the metal salt to obtain a carbonate compound, in which m is an integer of 1-10, Q is an alkylene group having 1 to 4 carbon atoms, etc, and R 10 and R 11 are alkyl groups having 1 to 5 carbon atoms, etc.

  本发明涉及一种生产过程，能够在高产率下有选择地生产各种碳酸盐化合物，而不使用像光气和冠醚这样的有毒化合物，也不产生像氯化氢这样的腐蚀性气体作为副产品，也不需要通过蒸馏去除氯仿作为副产品，以及一种制备碳酸盐化合物的方法，其中包括在金属盐和化合物（1）的存在下，将化合物（1）与具有羟基的化合物反应，每摩尔金属盐添加0.2到4.0摩尔的化合物（2），以获得碳酸盐化合物，其中m是1-10的整数，Q是具有1到4个碳原子的烷基基团，R10和R11是具有1到5个碳原子的烷基基团等。
• 4,4-BIS[(ETHENYLOXY)METHYL]CYCLOHEXENE AND METHOD FOR PRODUCING SAME
  申请人：Aburai Youhei

  公开号：US20140058136A1

  公开（公告）日：2014-02-27

  A novel substance, 4,4-bis[(ethenyloxy)methyl]cyclohexene having the formula (I), which is low in odor, low in volatility, and low in skin irritability, and therefore, can be used as, for example, a starting material for inks and a starting material for electronic materials, and a method for producing the same are provided:

  提供了一种新的物质4,4-双[(乙烯氧基)甲基]环己烯，其化学式为(I)，具有低气味、低挥发性和低皮肤刺激性，因此可以用作油墨和电子材料的起始原料，同时提供了一种制备该物质的方法。
• METHOD FOR PRODUCING a-HYDROXYCARBOXYLIC ACID DIMERIC CYCLIC ESTER
  申请人：Kureha Corporation

  公开号：US20190330175A1

  公开（公告）日：2019-10-31

  Provided is a method for producing a high purity α-hydroxycarboxylic acid dimeric cyclic ester while heavy-component formation from an α-hydroxycarboxylic acid oligomer is suppressed. An α-hydroxycarboxylic acid dimeric cyclic ester is obtained by performing a depolymerization reaction in the coexistence of an inorganic acid or an inorganic acid salt or a mixture thereof; and an organophosphorus compound.

  提供了一种制备高纯度α-羟基羧酸二聚环酯的方法，同时抑制从α-羟基羧酸寡聚体中形成重组分。通过在无机酸或无机酸盐或二者混合物的共存下进行解聚反应，并加入有机磷化合物，可以得到α-羟基羧酸二聚环酯。
• COMPOSITION FOR ABSORPTION REFRIGERATOR
  申请人：SANYO ELECTRIC CO., LTD.

  公开号：EP0048281A1

  公开（公告）日：1982-03-31

  A composition for an absorption refrigerator, which contains at least one fluorinated alcohol refrigerant containing 2 to 10 carbon atoms, is liquid at ordinary temperature, and becomes volatile upon heating under ordinary or reduced pressure, and at least one absorbent having a higher boiling point than said refrigerant at ordinary pressure and being capable of absorbing said refrigerant; and an absorption-refrigerating system using said composition.

  一种用于吸收式制冷机的组合物，它包含至少一种含 2 至 10 个碳原子的氟化醇制冷剂，在常温下为液态，在常压或减压下加热时变为挥发性，以及至少一种吸收剂，在常压下其沸点高于所述制冷剂，并能吸收所述制冷剂；以及一种使用所述组合物的吸收式制冷系统。