1-Thiophen-3-yl-3-trimethylsilylbut-3-en-1-one | 144500-91-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Thiophen-3-yl-3-trimethylsilylbut-3-en-1-one
• CAS: 144500-91-4
• 化学式: C₁₁H₁₆OSSi
• 分子量: 224.399
• InChiKey: HFFLEFZGEFQOPU-UHFFFAOYSA-N

物化性质

• 沸点：
  294.7±30.0 °C(Predicted)
• 密度：
  1.003±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.75
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  45.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-Thiophen-3-yl-3-trimethylsilylbut-3-en-1-one 以83%的产率得到
  参考文献：
  名称：

  Kang Kyung-Tae, U Jong Sun, Hwang Seong Sim, Jyung Kyung Kyu, Synth. Commun, 24 (1994) N 20, S 2915-2922

  摘要：

  DOI：
• 作为产物：
  描述：

  3-噻吩甲酰氯 、 2,3-二(三甲基硅基)-1-丙烯 在 三氯化铝 作用下， 生成 1-Thiophen-3-yl-3-trimethylsilylbut-3-en-1-one
  参考文献：
  名称：

  Synthesis ofβ-Trimethylsilyl-β, γ-unsaturated Ketones via Lewis Acid Promoted Reactions of 2,3-bis(Trimethylsilyl)-propene with Acid Chlorides

  摘要：

  Reactions of 2,3-bis(trimethylsilyl)propene with acid chlorides in the presence of aluminum chloride give beta-trimethylsilyl-beta,gamma-unsaturated ketones in high yields.

  DOI：

  10.1080/00397919408010150

文献信息

• Lewis acid mediated reactions of 2-stannyl-3-silylpropene with acid chlorides. Formation of vinylsilanes via 1,2-silyl migration and destannylation.
  作者：Kyung-Tae Kang、Jae Chul Lee、Sun U. Jong

  DOI：10.1016/s0040-4039(00)61243-1

  日期：1992.8

  Reactions of 2-stannyl-3-silylpropene with acid chlorides in the presence of Lewis acid afford vinylsilanes via 1,2-silyl migration followed by destannylation.
• Kang Kyung-Tae, Sun U. Jong, Synth. Commun, 24 (1994) N 11, S 1507-1512
  作者：Kang Kyung-Tae, Sun U. Jong

  DOI：——

  日期：——
• Kang Kyung-Tae, U Jong Sun, Hwang Seong Sim, Jyung Kyung Kyu, Synth. Commun, 24 (1994) N 20, S 2915-2922
  作者：Kang Kyung-Tae, U Jong Sun, Hwang Seong Sim, Jyung Kyung Kyu

  DOI：——

  日期：——
• Synthesis of 2-Substituted-4-Trimethylsilylfurans Using 2,3-bis(Trimethylsilyl)Propene
  作者：Kyung-Tae Kang、Jong Sun U、Seong Sim Hwang、Kyung Kyu Jyung

  DOI：10.1080/00397919408010613

  日期：1994.11

  2-Substituted-4-trimethylsilylfurans were prepared by treatment of the epoxycarbonyl compounds 3 with LDA or t-BuLi. 3a-j were obtained from the Lewis acid mediated reaction of 2,3-bis(trimethylsilyl)propene with acid chlorides and followed by epoxidation with MCPBA.
• Synthesis of<i>β</i>-Trimethylsilyl-<i>β, γ</i>-unsaturated Ketones via Lewis Acid Promoted Reactions of 2,3-<i>bis</i>(Trimethylsilyl)-propene with Acid Chlorides
  作者：Kyung-Tae Kang、Jong Sun U

  DOI：10.1080/00397919408010150

  日期：1994.6

  Reactions of 2,3-bis(trimethylsilyl)propene with acid chlorides in the presence of aluminum chloride give beta-trimethylsilyl-beta,gamma-unsaturated ketones in high yields.