4,5-dihydro-7-pentoxy-tetrazolo[1,5-a]quinoline | 1352080-21-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4,5-dihydro-7-pentoxy-tetrazolo[1,5-a]quinoline
• 英文别名: 7-Pentoxy-4,5-dihydrotetrazolo[1,5-a]quinoline；7-pentoxy-4,5-dihydrotetrazolo[1,5-a]quinoline
• CAS: 1352080-21-7
• 化学式: C₁₄H₁₈N₄O
• 分子量: 258.323
• InChiKey: MHUZVPJVDPIJFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  52.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6-(benzyloxy)-3,4-dihydroquinolin-2(1H)-one 在 tetraphosphorus decasulfide 、 hydrazine hydrate 、 硫酸 、 palladium 10% on activated carbon 、 氢气 、 三乙胺 、 sodium hydroxide 、 sodium nitrite 作用下， 以 四氢呋喃 、 乙醇 、 水 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 20.0~80.0 ℃ 、310.27 kPa 条件下， 反应 7.0h， 生成 4,5-dihydro-7-pentoxy-tetrazolo[1,5-a]quinoline
  参考文献：
  名称：

  Synthesis and study of the antidepressant activity of novel 4,5-dihydro-7-alkoxy(phenoxy)-tetrazolo[1,5-a]quinoline derivatives

  摘要：

  In this study, a novel series of 4,5-dihydro-7-alkoxy(phenoxy)-tetrazolo[1,5-a]quinoline derivatives was synthesized as potential antidepressant agents. Their antidepressant activities were evaluated by the forced swimming test and tail suspension test models. The pharmacological results showed that 7-(4-fluorobenzyloxy)-4,5-dihydrotetrazolo[1,5-a]quinoline 7j was found possessing strong activity in the both tests, especially in the FTS model, which was considered as the most promising compounds in this study.

  DOI：

  10.1007/s00044-011-9922-8

文献信息

• Synthesis and study of the antidepressant activity of novel 4,5-dihydro-7-alkoxy(phenoxy)-tetrazolo[1,5-a]quinoline derivatives
  作者：Xian-Yu Sun、Xian-Jing He、Chun-Yuan Pan、Yan-Peng Liu、Yun-Peng Zou

  DOI：10.1007/s00044-011-9922-8

  日期：2012.11

  In this study, a novel series of 4,5-dihydro-7-alkoxy(phenoxy)-tetrazolo[1,5-a]quinoline derivatives was synthesized as potential antidepressant agents. Their antidepressant activities were evaluated by the forced swimming test and tail suspension test models. The pharmacological results showed that 7-(4-fluorobenzyloxy)-4,5-dihydrotetrazolo[1,5-a]quinoline 7j was found possessing strong activity in the both tests, especially in the FTS model, which was considered as the most promising compounds in this study.