(2-ethyl-1-methylcyclopropyl)methanol | 113235-17-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2-ethyl-1-methylcyclopropyl)methanol
• CAS: 113235-17-9；113235-18-0
• 化学式: C₇H₁₄O
• 分子量: 114.188
• InChiKey: HWEOUQRUUBUANF-UHFFFAOYSA-N

物化性质

• 沸点：
  142.8±8.0 °C(Predicted)
• 密度：
  0.893±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  Trimethyl-[1-(2-methyl-oxiranylmethyl)-propyl]-stannane 在 三氟化硼乙醚 作用下， 以 二氯甲烷 为溶剂， 以56%的产率得到(2-ethyl-1-methylcyclopropyl)methanol
  参考文献：
  名称：

  Sato, Tadashi; Watanabe, Masami; Murayama, Eigoro, Synthetic Communications, 1987, vol. 17, # 7, p. 781 - 788

  摘要：

  DOI：

文献信息

• CYCLOPROPANE COMPOUND
  申请人：Terauchi Taro

  公开号：US20120095031A1

  公开（公告）日：2012-04-19

  A cyclopropane compound represented by the following formula (A) or a pharmaceutically acceptable salt thereof has orexin receptor antagonism, and therefore has a potencial of usefulness for the treatment of sleep disorder for which orexin receptor antagonism is effective, for example, insomnia: wherein Q represents —CH— or a nitrogen atom, R 1a and R 1b each independently represent a C 1-6 alkyl group and the like, R 1c represents a hydrogen atom and the like, R 2a , R 2b , R 2c and R 2d each independently represent a hydrogen atom, a halogen atom, a C 1-6 alkyl group and the like, R 3a , R 3b and R 3c each independently represent a hydrogen atom, a halogen atom and the like, and R 3d represents a hydrogen atom and the like.

  一种环丙烷化合物，其化学式如下（A），或其药学上可接受的盐具有促进俄雷昔康受体拮抗作用，因此具有治疗俄雷昔康受体拮抗有效的睡眠障碍的潜力，例如失眠：其中Q代表—CH—或氮原子，R1a和R1b分别独立表示C1-6烷基基团等，R1c表示氢原子等，R2a，R2b，R2c和R2d分别独立表示氢原子，卤素原子，C1-6烷基基团等，R3a，R3b和R3c分别独立表示氢原子，卤素原子等，R3d表示氢原子等。
• CYCLOPROPANE DERIVATIVES
  申请人：Terauchi Taro

  公开号：US20120165339A1

  公开（公告）日：2012-06-28

  A cyclopropane derivative represented by the following formula (I) or a pharmaceutically acceptable salt thereof has orexin receptor inhibitory action, and thus, is extremely useful as an agent for preventing or treating sleep disorder or dyssomnia caused by orexin, including insomnia as a typical example: wherein A 1 , A 2 and A 3 each independently represent an aryl group, a heterocyclyl group or the like, R 1 , R 2 and R 3 each independently represent a hydrogen atom, a C 1-6 alkyl group or the like, X represents an oxygen atom or the like, and L represents a bond or the like.

  由以下公式（I）表示的环丙烷衍生物或其药用可接受的盐具有促进促进醒脑肽受体的作用，因此，极其有用作为预防或治疗由促进醒脑肽引起的睡眠障碍或失眠症的药物，包括失眠作为典型例子：其中A1、A2和A3各自独立地表示芳基、杂环烷基或类似物，R1、R2和R3各自独立地表示氢原子、C1-6烷基或类似物，X表示氧原子或类似物，L表示键或类似物。
• Mechanism-Based Design and Optimization of a Catalytic Electrophilic Cyclopropanation without Diazomethane
  作者：Augustin A. S. W. Tchawou、Mihai Raducan、Peter Chen

  DOI：10.1021/acs.organomet.6b00531

  日期：2017.1.9

  Iodomethylboron compounds, either the trifluoroborate or a boronic ester, cyclopropanate electron-rich olefins and unprotected allylic alcohols with Pd catalysts according to a novel, designed catalytic cycle. Proposed intermediates in a "diverted Heck" mechanism are observed by means of spectroscopic studies and by isolation and X-ray crystallographic characterization, which together with reaction kinetics point to a separation of rate-determining and product-determining steps, and a mechanism-based optimization of the yield, selectivity, and scope of the catalytic electrophilic cyclopropanation. The reaction with crystalline, air-stable, nonhygroscopic, and nontoxic reagents provides an alternative to Simmons Smith-type reactions, as well as cyclopropanation procedures that require the use of diazomethane.
• SATO TADASHI; WATANABE MASAMI; MURAYAMA EIGORO, SYNTH. COMMUN., 17,(1987) N 7, 781-788
  作者：SATO TADASHI、 WATANABE MASAMI、 MURAYAMA EIGORO

  DOI：——

  日期：——
• US8268848B2
  申请人：——

  公开号：US8268848B2

  公开（公告）日：2012-09-18