1-(4-(4-iodophenyl)thiazol-2-yl)-2-(pentan-3-ylidene)hydrazine | 1383114-65-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(4-(4-iodophenyl)thiazol-2-yl)-2-(pentan-3-ylidene)hydrazine
• 英文别名: N-(1-ethylpropylideneamino)-4-(4-iodophenyl)thiazol-2-amine；4-(4-iodophenyl)-N-(pentan-3-ylideneamino)-1,3-thiazol-2-amine
• CAS: 1383114-65-5
• 化学式: C₁₄H₁₆IN₃S
• 分子量: 385.272
• InChiKey: BWJDMZWRGKGUMP-UHFFFAOYSA-N

物化性质

• 熔点：
  184-185 °C
• 沸点：
  450.3±47.0 °C(predicted)
• 密度：
  1.56±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  65.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-碘代苯乙酮 在 溴 作用下， 以 乙醇 、 氯仿 为溶剂， 反应 14.0h， 生成 1-(4-(4-iodophenyl)thiazol-2-yl)-2-(pentan-3-ylidene)hydrazine
  参考文献：
  名称：

  Synthesis, anti-Candida activity, and cytotoxicity of new (4-(4-iodophenyl)thiazol-2-yl)hydrazine derivatives

  摘要：

  Novel (4-(4-iodophenyl)-thiazol-2-yl)hydrazine derivatives were assayed for their in vitro anti-Candida activity, compared to topical and systemic antifungal drugs, against twenty-seven clinical isolates. The presence of aliphatic chains or specific heteroaromatic rings on hydrazone moiety at position C2 and a 4-iodophenyl at C4 of the thiazole ring gave a promising inhibitory activity especially against Candida albicans and Candida krusei. The most active compounds have been also evaluated for their cytotoxicity and in association with clotrimazole for anti-Candida activity. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.04.006

文献信息

• Synthesis, anti-Candida activity, and cytotoxicity of new (4-(4-iodophenyl)thiazol-2-yl)hydrazine derivatives
  作者：Daniela Secci、Bruna Bizzarri、Adriana Bolasco、Simone Carradori、Melissa D'Ascenzio、Daniela Rivanera、Emanuela Mari、Lucia Polletta、Alessandra Zicari

  DOI：10.1016/j.ejmech.2012.04.006

  日期：2012.7

  Novel (4-(4-iodophenyl)-thiazol-2-yl)hydrazine derivatives were assayed for their in vitro anti-Candida activity, compared to topical and systemic antifungal drugs, against twenty-seven clinical isolates. The presence of aliphatic chains or specific heteroaromatic rings on hydrazone moiety at position C2 and a 4-iodophenyl at C4 of the thiazole ring gave a promising inhibitory activity especially against Candida albicans and Candida krusei. The most active compounds have been also evaluated for their cytotoxicity and in association with clotrimazole for anti-Candida activity. (C) 2012 Elsevier Masson SAS. All rights reserved.