(2E,2'E)-1,1'-(1,3-phenylene)bis(3-(4-methoxyphenyl)prop-2-en-1-one) | 132843-69-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (2E,2'E)-1,1'-(1,3-phenylene)bis(3-(4-methoxyphenyl)prop-2-en-1-one)
• 英文别名: 1,3-bis-(4-methoxy-trans-cinnamoyl)-benzene of mp: 135 degree；1,3-Bis-(4-methoxy-trans-cinnamoyl)-benzol vom F:135grad；(E)-3-(4-methoxyphenyl)-1-[3-[(E)-3-(4-methoxyphenyl)prop-2-enoyl]phenyl]prop-2-en-1-one
• CAS: 132843-69-7
• 化学式: C₂₆H₂₂O₄
• 分子量: 398.458
• InChiKey: IPABLGMAPCTPSM-OTYYAQKOSA-N

物化性质

• 沸点：
  614.2±55.0 °C(Predicted)
• 密度：
  1.178±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2E,2'E)-1,1'-(1,3-phenylene)bis(3-(4-methoxyphenyl)prop-2-en-1-one) 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 4.0h， 生成 C₂₆H₂₆N₄O₂
  参考文献：
  名称：

  Al-Omran, Fatima; Al-Awadi, Nouria; Edun, Mustafa, Journal of Chemical Research, Miniprint, 1994, # 5, p. 1026 - 1041

  摘要：

  DOI：
• 作为产物：
  描述：

  3,3'-dioxo-3,3'-m-phenylene-di-propionic acid 在 sodium hydroxide 、 乙醇 、 硫酸 作用下， 生成 (2E,2'E)-1,1'-(1,3-phenylene)bis(3-(4-methoxyphenyl)prop-2-en-1-one)
  参考文献：
  名称：

  ÜberDi-和Tri-acetyl-benzol和p-Phenylen-di-glyoxal（43. MitteilungüberStickstoff-Heterocyclen）

  摘要：

  DOI：

  10.1002/hlca.19390220162

文献信息

• Synthesis of Some New Bis[1-(2-aroyl-3-aryl)cyclopropylcarbonyl]benzenes and Pyridines under Phase Transfer Catalysis (PTC) Method
  作者：Dandu Bhaskar Reddy、Biradavolu Seenaiah、Adivireddi Padmaja、Pallela Venkata Ramana Reddy

  DOI：10.1135/cccc19931437

  日期：——

  Some new bis[1-(2-aroyl-3-aryl)cyclopropylcarbonyl]benzenes and pyridines IV - VI have been prepared by the cycloaddition of dimethylsulfonium phenacylide to 1,1'-(1,3-, 1,4-phenylene, and 2,6-pyridylene)-bis(3-aryl-2-propen-1-ones) I - III by adopting two different methods. The advantages of the PTC method over the other have been discussed. The structures of the compound have been confirmed by spectral data.

  一些新的双[1-(2-芳酰基-3-芳基)环丙基羰基]苯和吡啶已通过将二甲基亚砜苯乙炔与1,1'-(1,3-, 1,4-苯基和2,6-吡啶基)-双(3-芳基-2-丙烯-1-酮)进行环加成反应而制备，采用了两种不同的方法。讨论了PTC方法相对于其他方法的优势。该化合物的结构已通过光谱数据确认。
• Analogues of xanthones——Chalcones and bis-chalcones as α-glucosidase inhibitors and anti-diabetes candidates
  作者：Chao-Yun Cai、Li Rao、Yong Rao、Jin-Xuan Guo、Zhi-Zun Xiao、Jing-Yu Cao、Zhi-Shu Huang、Bo Wang

  DOI：10.1016/j.ejmech.2017.02.007

  日期：2017.4

  Two series of compounds (chalcones and bis-chalcones) were designed, synthesized, and evaluated as aglucosidase inhibitors (AGIs) with 1-deoxynojirimycin as positive control in vitro. Most of the compounds with two or four hydroxyl groups showed better inhibitory activities than 1-deoxynojirimycin towards aglucosidase with noncompetitive mechanism. Moreover, most of the hydroxy bis-chalcones exhibit good a-glucosidase inhibitory activities in enzyme test. Inspiringly, bis-chalcones 2g (at 1 mu M concentration) has stronger effect than 1-deoxynojirimycin on reducing the glucose level in HepG-2 cells (human liver cancer cell line). (C) 2017 Elsevier Masson SAS. All rights reserved.
• Reddy, D. Bhaskar; Seenaiah, B.; Padmavathi, V., Phosphorus, Sulfur and Silicon and the Related Elements, 1992, vol. 69, # 1-2, p. 31 - 42
  作者：Reddy, D. Bhaskar、Seenaiah, B.、Padmavathi, V.、Seshamma, T.

  DOI：——

  日期：——
• Bhaskar Reddy; Seenaiah; Muralidhar Reddy, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996, vol. 35, # 10, p. 1012 - 1016
  作者：Bhaskar Reddy、Seenaiah、Muralidhar Reddy

  DOI：——

  日期：——
• Reddy; Seshamma; Seenaiah, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1991, vol. 30, # 1, p. 46 - 51
  作者：Reddy、Seshamma、Seenaiah、Ramana Reddy

  DOI：——

  日期：——