Methyl 2-amino-2-methylpentanoate | 777036-35-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methyl 2-amino-2-methylpentanoate
• CAS: 777036-35-8
• 化学式: C₇H₁₅NO₂
• mdl: MFCD13690892
• 分子量: 145.202
• InChiKey: UCEMIMRGLBPPLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Methyl 2-amino-2-methylpentanoate 在 5%-palladium/activated carbon 、 水 、 氢气 、 溶剂黄146 、 N,N-二异丙基乙胺 、 lithium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 氯仿 为溶剂， 20.0~200.0 ℃ 、100.0 kPa 条件下， 反应 59.0h， 生成 3-Methyl-2,5-dioxo-3-propyl-1,4-dihydro-1,4-benzodiazepine-7-sulfonyl chloride
  参考文献：
  名称：

  Identification and design of a novel series of MGAT2 inhibitors

  摘要：

  [Acyl CoA]monoacylglycerol acyltransferase 2 (MGAT2) is of interest as a target for therapeutic treatment of diabetes, obesity and other diseases which together constitute the metabolic syndrome. In this Letter we report our discovery and optimisation of a novel series of MGAT2 inhibitors. The development of the SAR of the series and a detailed discussion around some key parameters monitored and addressed during the lead generation phase will be given. The in vivo results from an oral lipid tolerance test (OLTT) using the MGAT2 inhibitor (S)-10, shows a significant reduction (68% inhibition relative to naive, p < 0.01) in plasma triacylglycerol (TAG) concentration. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.02.084

文献信息

• METHOD FOR PREPARING OPTICALLY ACTIVE AMINO ACID USING COSUBSTRATE SHUTTLING OF TRANSAMINASE
  申请人：INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

  公开号：US20150284750A1

  公开（公告）日：2015-10-08

  The present disclosure relates to a method for preparing an optically active amino acid using cosubstrate shuttling of transaminase. The method includes coupling a reaction of converting a keto acid to an amino acid by α-transaminase and a reaction of transferring an amino group of an amine substrate by ω-transaminase (TA) using an amino acid cosubstrate. The present disclosure allows production of various optically active amino acids with high purity and high efficiency by solving the low equilibrium constant problem of transaminase and is applicable to production of various optically active amino acids in industrial scale. Since the present disclosure allows easy production of various unnatural amino acids having high reactivity and stability, which are used as pharmaceutical precursors, it can be usefully employed in preparation of pharmaceuticals, food additives and various animal feeds.

  本公开涉及使用共基底穿梭转氨酶的方法制备光学活性氨基酸。该方法包括使用氨基酸共基底耦合α-转氨酶将酮酸转化为氨基酸的反应和使用ω-转氨酶（TA）转移胺基底物的胺基的反应。本公开解决了转氨酶低平衡常数问题，可高效高纯度地生产各种光学活性氨基酸，并适用于工业规模生产。由于本公开允许轻松生产具有高反应性和稳定性的各种非天然氨基酸，这些氨基酸可用作制药前体，因此可以在制备药物、食品添加剂和各种动物饲料方面得到有用的应用。
• Hepatitis C inhibitor tri-peptides
  申请人：BOEHRINGER INGELHEIM (CANADA) LTD.

  公开号：EP2028186B1

  公开（公告）日：2013-01-23
• US9376694B2
  申请人：——

  公开号：US9376694B2

  公开（公告）日：2016-06-28
• Identification and design of a novel series of MGAT2 inhibitors
  作者：Jonas G. Barlind、Linda K. Buckett、Sharon G. Crosby、Öjvind Davidsson、Hans Emtenäs、Anne Ertan、Ulrik Jurva、Malin Lemurell、Pablo Morentin Gutierrez、Karolina Nilsson、Gavin O’Mahony、Annika U. Petersson、Alma Redzic、Fredrik Wågberg、Zhong-Qing Yuan

  DOI：10.1016/j.bmcl.2013.02.084

  日期：2013.5

  [Acyl CoA]monoacylglycerol acyltransferase 2 (MGAT2) is of interest as a target for therapeutic treatment of diabetes, obesity and other diseases which together constitute the metabolic syndrome. In this Letter we report our discovery and optimisation of a novel series of MGAT2 inhibitors. The development of the SAR of the series and a detailed discussion around some key parameters monitored and addressed during the lead generation phase will be given. The in vivo results from an oral lipid tolerance test (OLTT) using the MGAT2 inhibitor (S)-10, shows a significant reduction (68% inhibition relative to naive, p < 0.01) in plasma triacylglycerol (TAG) concentration. (C) 2013 Elsevier Ltd. All rights reserved.